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公开(公告)号：US08338605B2
公开(公告)日：2012-12-25
申请号：US12817808
申请日：2010-06-17
申请人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V. L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V. L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译： 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US20120220562A1
公开(公告)日：2012-08-30
申请号：US13404429
申请日：2012-02-24
申请人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
发明人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
IPC分类号： A61K31/496 , A61K31/506 , A61K31/4545 , A61P31/14 , C07D403/14 , C07D401/14 , C07D405/14 , A61K31/4178 , A61K31/454
CPC分类号： C07D403/14 , C07D207/16
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20120082646A1
公开(公告)日：2012-04-05
申请号：US13260199
申请日：2010-03-25
申请人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
发明人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号： A61K31/513 , C07D409/08 , C07D213/64 , C07C311/08 , C07D233/72 , A61P31/14 , A61K31/18 , A61K31/4166 , A61K31/27 , C12N9/99 , A61K38/21 , A61K31/7056 , C07D239/54 , A61K31/4418
CPC分类号： C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US07763731B2
公开(公告)日：2010-07-27
申请号：US11613836
申请日：2006-12-20
申请人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译： 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US07378414B2
公开(公告)日：2008-05-27
申请号：US10925072
申请日：2004-08-24
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D285/26 , A61K31/549
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US20070142353A1
公开(公告)日：2007-06-21
申请号：US11675160
申请日：2007-02-15
申请人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
发明人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
IPC分类号： A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4743 , C07D498/02 , C07D487/02
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译： 公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。
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公开(公告)号：US07196200B2
公开(公告)日：2007-03-27
申请号：US10762002
申请日：2004-01-21
申请人： David D. Anderson , Bruce A. Beutel , Curt S. Cooper , Yu-Gui Gu , Mira M. Hinman , Douglas M. Kalvin , Robert F. Keyes , Xenia B. Searle , Rolf Wagner
发明人： David D. Anderson , Bruce A. Beutel , Curt S. Cooper , Yu-Gui Gu , Mira M. Hinman , Douglas M. Kalvin , Robert F. Keyes , Xenia B. Searle , Rolf Wagner
IPC分类号： C07D277/60 , A01N43/78
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译： 具有式（I）的细菌蛋白质合成抑制化合物
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公开(公告)号：US07135468B2
公开(公告)日：2006-11-14
申请号：US11051907
申请日：2005-02-04
申请人： Mira M. Hinman , Teresa A. Rosenberg , Rolf Wagner
发明人： Mira M. Hinman , Teresa A. Rosenberg , Rolf Wagner
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/5365
CPC分类号： C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
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59.发明授权
公开(公告)号：US5508437A
公开(公告)日：1996-04-16
申请号：US169481
申请日：1993-12-17
IPC分类号： A61K38/00 , C07K14/595 , C07D207/36 , C07C229/34
CPC分类号： C07K14/595 , A61K38/00
摘要： Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
摘要翻译： 含有酪氨酸硫酸酯或含酪氨酸磷酸酯的肽的类似物，用于制备这些类似物的新型中间体化合物，以及通过向受试者施用有效量的CCK类似物来抑制受试者的食欲的方法，其中一种或多种任何酪氨酸 硫酸盐存在被本发明的基团取代。
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公开(公告)号：US08921514B2
公开(公告)日：2014-12-30
申请号：US12964027
申请日：2010-12-09
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/66 , C07K16/00 , C07D453/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D491/113
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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