公开(公告)号：US08052619B2

公开(公告)日：2011-11-08

申请号：US12162612

申请日：2007-01-30

申请人： Masaki Fujiwara ,  Yoshinori Amano

发明人： Masaki Fujiwara ,  Yoshinori Amano

IPC分类号： B23H3/02 ,  B23H7/14 ,  C25B9/04 ,  C25B9/00 ,  C12M1/00 ,  C12N9/00 ,  G01N27/26 ,  A61B5/00 ,  B65D81/00

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519 ,  A61B2562/0295

摘要： A blood sensor to be used in a blood test apparatus, more specifically speaking, a blood sensor which can be easily attached to a blood test apparatus and detached therefrom. Namely, a blood sensor to be detachably attached to a blood test apparatus having a plural number of connectors, which comprises: a supply channel to which blood is supplied; a detection section provided in the supply channel; an electrode system formed in an area including the detection section; a plural number of connection terminals electrically connected to each electrode of the electrode system respectively; and a standard electrode serving as a standard for differentiating these connection terminals. The connectors are connected respectively to the connection terminals and the standard electrode of the blood sensor having been attached to a definite position of the blood test apparatus.

摘要翻译： 用于血液检查装置的血液传感器，更具体地说，可以容易地安装在血液检查装置上并从中分离的血液传感器。 即，可拆卸地安装在具有多个连接器的血液检查装置上的血液传感器，包括：供给血液的供给通道; 设置在所述供给通道中的检测部; 形成在包括检测部的区域中的电极系统; 多个连接端子分别电连接到电极系统的每个电极; 以及用作区分这些连接端子的标准的标准电极。 连接器分别连接到血液检测装置的确定位置的连接端子和血液传感器的标准电极。

公开(公告)号：US20110269917A1

公开(公告)日：2011-11-03

申请号：US12770877

申请日：2010-04-30

申请人： Masaki Fujiwara ,  James L. Hedrick ,  Daniel P. Sanders ,  Manabu Yasumoto

发明人： Masaki Fujiwara ,  James L. Hedrick ,  Daniel P. Sanders ,  Manabu Yasumoto

IPC分类号： C08G64/00 ,  C07D317/24 ,  C08L69/00 ,  C07D319/06

CPC分类号： C07D319/04 ,  C07D317/36 ,  C08G64/0233 ,  C08G64/30 ,  Y02P20/582

摘要： A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

摘要翻译： 公开了一种制备包含活性五氟苯基碳酸酯基团的环状羰基化合物的一锅法。 环状羰基化合物可以通过开环方法聚合以形成包含包含侧链五氟苯基碳酸酯基团的重复单元的ROP聚合物。 使用合适的亲核试剂，可以在开环聚合之前或之后将五氟苯基五氟苯基碳酸酯基团选择性地转化成多种其它官能团。

公开(公告)号：US07998325B2

公开(公告)日：2011-08-16

申请号：US10809217

申请日：2004-03-25

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

摘要翻译： 公开了一种生物传感器，其包括支撑件; 由诸如金或钯等贵金属的导电材料和碳组成的导电层; 平行于和垂直于支撑体侧面的狭缝; 工作，计数器和检测电极; 覆盖支架上的工作电极，反电极和检测电极的间隔件; 在间隔件中形成矩形切口，形成试样供应路径; 样品供应路径的入口; 通过将含有酶的试剂施加到通过所述间隔件中的切口暴露的所述工作，反向和检测电极而形成的试剂层; 和间隔物上的盖子。 可以通过简单的方法形成生物传感器，并且不管试剂组成如何，在电极上提供均匀的试剂层。

公开(公告)号：US20110174613A1

公开(公告)日：2011-07-21

申请号：US12930627

申请日：2011-01-11

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

IPC分类号： G01N27/403

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

公开(公告)号：US07976478B2

公开(公告)日：2011-07-12

申请号：US12293670

申请日：2007-03-22

申请人： Masaki Fujiwara ,  Yoshinori Amano ,  Kenichi Hamanaka ,  Motonori Uchiyama ,  Masataka Nadaoka ,  Toshihiro Akiyama ,  Koji Miyoshi

发明人： Masaki Fujiwara ,  Yoshinori Amano ,  Kenichi Hamanaka ,  Motonori Uchiyama ,  Masataka Nadaoka ,  Toshihiro Akiyama ,  Koji Miyoshi

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： A61B5/15138 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150145 ,  A61B5/150213 ,  A61B5/150229 ,  A61B5/150259 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150954 ,  A61B5/157 ,  A61B5/6843

摘要： A blood test apparatus having a simple constitution whereby stable measurement can be conducted by surely sampling the blood in an amount being small but sufficient for the test without placing too much burden on a patient. When a first skin contact sensor of this apparatus detects the skin, driving of a negative pressure unit is initiated (time point 166a). Thus, the skin rises and comes into contact with a second skin contact sensor (time point 166b). After piercing into the skin at time point 166c, the negative pressure supply is once ceased. Next, the negative pressure is applied again at time point 166d for a definite period of time. Thus, the opening in the skin is broadened, which facilitates the flow out of the blood (16).

摘要翻译： 一种具有简单结构的血液检查装置，其可以通过对血液进行可靠的取样来进行稳定的测量，其量小但足以用于测试，而不会对患者造成太多的负担。 当该装置的第一皮肤接触传感器检测到皮肤时，启动负压单元的驱动（时间点166a）。 因此，皮肤上升并与第二皮肤接触传感器接触（时间点166b）。 在时间点166c刺入皮肤后，负压供应一旦停止。 接下来，在时间点166d再次施加负压一定时间。 因此，皮肤上的开口变宽，这有助于流出血液（16）。

公开(公告)号：US20100243476A1

公开(公告)日：2010-09-30

申请号：US12377514

申请日：2007-10-17

申请人： Masaki Fujiwara ,  Shin Ikeda ,  Takahiro Nakaminami

发明人： Masaki Fujiwara ,  Shin Ikeda ,  Takahiro Nakaminami

IPC分类号： G01N27/26 ,  G01N33/50

CPC分类号： G01N27/3274 ,  G01N27/3272 ,  G01N27/413

摘要： Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b). A first reagent (13) consisting essentially of an oxidant in a redox substance is disposed in contact with the surface of a counter electrode which faces the branch part (18b), and a second reagent (19) consisting essentially of a reductant is disposed in contact with the surface of a working electrode that faces the branch part (18a).

摘要翻译： 在氧化还原物质中的氧化剂基本上不与工作电极接触但与对电极接触的状态下，跨越对置电极和与血液样品接触的工作电极施加电压， 还原剂基本上不与对电极接触，而是与工作电极接触，由此还原剂和氧化剂分别被氧化和还原，以测量在氧化和还原时产生的电流。 根据上述结构，在降低施加在工作电极和对电极两端的电压的同时，能够以良好的检测灵敏度稳定地测定血液样品的Hct值。 该测量可以用包括工作电极（11），对电极（12）和具有分支部分（18a，18b）的血液样本保持部分（14）的传感器芯片进行。 基本上由氧化还原物质中的氧化剂组成的第一试剂（13）被设置成与面对分支部分（18b）的对电极的表面接触，并且基本上由还原剂组成的第二试剂（19）设置在 与面向分支部（18a）的工作电极的表面接触。

公开(公告)号：US20100006432A1

公开(公告)日：2010-01-14

申请号：US12456199

申请日：2009-06-12

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Takahiro Nakaminami ,  Junko Nakayama ,  Eriko Yamanishi

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Takahiro Nakaminami ,  Junko Nakayama ,  Eriko Yamanishi

IPC分类号： G01N27/30 ,  G01N27/26

CPC分类号： C12Q1/003

摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.

摘要翻译： 在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有 分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器 浓度。

公开(公告)号：US20090281455A1

公开(公告)日：2009-11-12

申请号：US12159904

申请日：2006-12-28

申请人： Masaki Fujiwara ,  Toshihiro Akiyama ,  Yoshinori Amano

发明人： Masaki Fujiwara ,  Toshihiro Akiyama ,  Yoshinori Amano

IPC分类号： A61B5/151

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150641 ,  A61B5/150702 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519 ,  A61B2562/0295

摘要： A blood test apparatus wherein a blood collection needle and a blood sensor can be easily attached and detached so that a burden or pain of a patient can be relieved. More specifically speaking, a blood test apparatus wherein a holder, a lancet, a blood collection needle and a blood sensor are united together as a blood sampling cartridge that is detachably mounted to the apparatus body. When this blood sampling cartridge is attached, a plunger involved in the apparatus body holds the lancet and connectors involved in the apparatus body come into contact with the blood sensor. It is preferable that the contact points with the blood sensor of the individual connectors are located at intervals at the same angle centering on a definite point.

摘要翻译： 一种血液检查装置，其中采血针和血液传感器可以容易地安装和分离，从而可以缓解患者的负担或疼痛。 更具体地说，其中将保持器，刺血针，采血针和血液传感器结合在一起的血液检查装置作为可拆卸地安装到装置主体的采血盒。 当该采血管被安装时，与装置主体相关的柱塞保持刺血针，并且装置主体中所涉及的连接器与血液传感器接触。 优选地，与各个连接器的血液传感器的接触点以定位点为中心的相同角度间隔开。

公开(公告)号：US20070007128A1

公开(公告)日：2007-01-11

申请号：US11519132

申请日：2006-09-12

申请人： Atsushi Tomyo ,  Eiji Takahashi ,  Masaki Fujiwara ,  Takashi Kotera ,  Masatoshi Onoda

发明人： Atsushi Tomyo ,  Eiji Takahashi ,  Masaki Fujiwara ,  Takashi Kotera ,  Masatoshi Onoda

IPC分类号： C23C14/00 ,  C23C16/00

CPC分类号： H01J37/321 ,  C23C14/165 ,  C23C14/3471

摘要： A silicon film forming apparatus includes a deposition chamber (10), a silicon sputter target (2) arranged in the chamber, a hydrogen gas supply circuit (102 or 102′) supplying a hydrogen gas into the chamber, and a high-frequency power applying device (antenna 1, 1′, power source PW and others) generating inductively coupled plasma by applying high-frequency power to the gas supplied into the deposition chamber (10). Chemical sputtering is effected on the target (2) by the plasma to form a silicon film on a substrate S. A silane gas may be used. A silane gas supply circuit (101) may be provided with a gas reservoir unit (GR). The silicon film can be formed inexpensively and fast at a relatively low temperature.

摘要翻译： 硅膜形成装置包括沉积室（10），布置在室中的硅溅射靶（2），将氢气供应到室中的氢气供应电路（102或102'）和高频功率 通过向供应到沉积室（10）的气体施加高频电力来产生电感耦合等离子体的施加装置（天线1,1'，电源PW等）。 通过等离子体在靶（2）上进行化学溅射，以在衬底S上形成硅膜。可以使用硅烷气体。 硅烷气体供给回路（101）也可以设置有气体储存部（GR）。 硅膜可以在相对较低的温度下廉价且快速地形成。

公开(公告)号：US06911131B2

公开(公告)日：2005-06-28

申请号：US09979842

申请日：2001-03-28

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Takahiro Nakaminami ,  Junko Nakayama ,  Eriko Yamanishi

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Takahiro Nakaminami ,  Junko Nakayama ,  Eriko Yamanishi

IPC分类号： C12Q1/00 ,  G01N27/327 ,  G01N21/00

CPC分类号： C12Q1/003

摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.

摘要翻译： 在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有 分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器 浓度。