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公开(公告)号：US09657282B2
公开(公告)日：2017-05-23
申请号：US15270469
申请日：2016-09-20
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/00 , C12N15/63 , C12N9/22 , A61K31/7115 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , C12N15/90 , G01N33/50 , A01K67/00 , A61K35/12
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US09464285B2
公开(公告)日：2016-10-11
申请号：US15156806
申请日：2016-05-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
Abstract translation: 本发明部分涉及编码蛋白质的核酸，包含编码蛋白质的核酸的治疗剂，使用核酸诱导细胞表达蛋白质的方法，用于转染，基因编辑和重编程细胞，细胞，生物体的方法，试剂盒和装置， 以及使用这些方法，试剂盒和装置制备的治疗剂。 描述了用于改变细胞DNA序列的方法和产物，以及用合成RNA分子诱导细胞表达蛋白质的方法和产物。 还描述了包含编码基因编辑蛋白的核酸的治疗剂。
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公开(公告)号：US20130344602A1
公开(公告)日：2013-12-26
申请号：US13931251
申请日：2013-06-28
Applicant: Factor Bioscience, Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C12N5/00
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
Abstract translation: 本发明部分地涉及从患者样品中产生组织特异性细胞的方法以及使用这些方法产生的组织特异性细胞。 公开了使用RNA重编程细胞的方法。 还公开了包含使用这些方法生产的细胞的治疗剂。
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公开(公告)号：US12201675B2
公开(公告)日：2025-01-21
申请号：US16562494
申请日：2019-09-06
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K48/00 , A61B18/18 , A61G19/00 , A61K8/60 , A61K9/00 , A61K9/127 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/38 , A61K38/39 , A61K38/44 , A61K38/45 , A61K45/06 , A61K47/46 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C12N15/87 , C12N15/90 , A61B18/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US12006508B2
公开(公告)日：2024-06-11
申请号：US16912321
申请日：2020-06-25
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , A61K31/7115 , A61K35/14 , A61K38/46 , A61K48/00 , C07K14/195 , C12N9/14 , C12N9/22 , C12N15/00 , C12N15/10 , C12N15/86 , C12N15/90 , G01N33/50 , A01K67/00 , A61K35/12
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , C07K14/195 , C12N9/22 , C12N15/1024 , C12N15/86 , C12Y301/00 , C12Y301/21004 , G01N33/5014 , A61K2035/124 , C07K2319/80 , C12N2800/80
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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Patent Agency Ranking
公开(公告)号：US20240182856A1
公开(公告)日：2024-06-06
申请号：US18461368
申请日：2023-09-05
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE , Mitchell KOPACZ , Jasmine HARRIS , James PAN
IPC: C12N5/0783 , C12N15/10
CPC classification number: C12N5/0646 , C12N15/102 , C12N2506/1307 , C12N2510/00
Abstract: The present disclosure relates in part to engineered immune cells that are, inter alia, silenced from a host immune response.
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公开(公告)号：US20240156987A1
公开(公告)日：2024-05-16
申请号：US18328598
申请日：2023-06-02
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE
IPC: A61K48/00 , A61K9/00 , A61K31/7115 , A61P1/16 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , C07K14/00 , C12N9/22
CPC classification number: A61K48/005 , A61K9/0019 , A61K31/7115 , A61K48/0058 , A61K48/0066 , A61P1/16 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , C07K14/001 , C12N9/22 , C07K14/003 , C12N2310/20 , C12Y301/21
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US20240035025A1
公开(公告)日：2024-02-01
申请号：US18480405
申请日：2023-10-03
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE , Aisha SVIHLA
CPC classification number: C12N15/11 , C07K14/4702 , C12N15/102 , C12N9/22 , C12N2310/20
Abstract: The present disclosure relates, in part, to circular RNAs and engineered variants thereof.
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公开(公告)号：US20230373903A1
公开(公告)日：2023-11-23
申请号：US18362789
申请日：2023-07-31
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Franklin KOSTAS , Christopher ROHDE
IPC: C07C215/24 , A61K9/127
CPC classification number: C07C215/24 , A61K9/1272
Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
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公开(公告)号：US20230304044A1
公开(公告)日：2023-09-28
申请号：US18332620
申请日：2023-06-09
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE
IPC: C12N15/87 , C08K5/5399 , C12N5/074 , H01L31/048 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C12N15/90 , C12N9/22 , A61K35/28
CPC classification number: C12N15/87 , C08K5/5399 , C12N5/0696 , H01L31/048 , C12P21/00 , C12N9/16 , C12Y301/21 , C12N5/0647 , C12N5/0657 , C12N15/907 , C12N9/22 , A61K35/28 , C08G77/08
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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