公开(公告)号：US10545076B2

公开(公告)日：2020-01-28

申请号：US15515794

申请日：2014-10-20

Applicant: Foss Analytical A/S

Inventor： Claus Holm ,  Malin Dahl ,  Christer Zoffmann Bisgaard

IPC: G01N1/40 ,  B01D11/02 ,  G01N1/34 ,  G01N30/60 ,  G01N30/06

Abstract: Determination of Analytes in a Sample Matrix by Solvent Extraction A method for the assay of one or more analytes in a sample matrix comprising the steps of: performing analyte extraction on the sample matrix, said analyte extraction comprising combining the sample matrix with a solvent for an extraction period which is less than that required for reaching equilibrium; and separating the analyte containing solvent from the sample matrix; next measuring a level of analyte present in the separated solvent; and then applying in a computer a calibration by which is established a mathematical relationship between levels of analyte extracted from each of a plurality of reference samples by means of the process employed above in the extraction for the sample matrix and a reference value of the levels of analyte for each reference sample to thereby derive a measure of the level of analyte in the sample matrix. Specifically a method to determine the amount of mycotoxins in cereal grain, especially OTA (ochratoxin A) and DON (deoxynivalenol) by mixing with a solvent comprising water alcohol mixture, with 20-40% ethanol by volume.

公开(公告)号：US20180328788A1

公开(公告)日：2018-11-15

申请号：US15539217

申请日：2015-02-02

Applicant: Foss Analytical A/S

Inventor： Steen Kjaer ANDERSEN ,  Mads Lykke ANDERSEN

IPC: G01J3/453 ,  G01J3/06

CPC classification number: G01J3/4535 ,  G01J3/06 ,  G01J3/45

Abstract: A spectrometer system comprises a scanning interferometer; a drive system mechanically coupled to a movable reflector element of the scanning interferometer and operable to effect reciprocation of the movable reflector element at a plurality, preferably more than two, for example three, different scan speeds; a detector arrangement configured to sample at equidistant time intervals an interferogram formed by the scanning interferometer to generate a sampled interferogram; and a data processor is adapted to acquire a sampled interferogram at each of the plurality of different scan speeds and to perform a relative comparison of the content of the so acquired plurality of sampled interferograms.

公开(公告)号：US09854817B2

公开(公告)日：2018-01-02

申请号：US14890580

申请日：2013-07-11

Applicant: Foss Analytical A/S

Inventor： Maja Kirstine Elsoee ,  Hans Larsen ,  Stefan Linn ,  Allan Kjaergaard Jensen

IPC: H05K7/20 ,  B02C18/30 ,  A22C17/00 ,  G01N33/12 ,  G01N23/083

CPC classification number: A22C17/0073 ,  A22C17/008 ,  G01N23/083 ,  G01N33/12 ,  G01N2223/618 ,  G01N2223/643 ,  G01N2223/652

Abstract: A meat processing device comprises a meat processing unit and an external X-ray meat analyzer provided with a housing formed with an inlet connectable with an outlet of the processing unit. The housing provides complete shielding of personnel from X-rays except towards the inlet and is movable relative to the processing unit to a first position for analysis at which the unit outlet is collocated with the inlet and at which the processing unit completes the shielding of personnel from X-rays towards the inlet.

公开(公告)号：US20170219484A1

公开(公告)日：2017-08-03

申请号：US15500658

申请日：2014-08-18

Applicant: Foss Analytical A/S

Inventor： Per Waaben HASSEN ,  Henrik Vilstrup JUHL ,  Lars NOERGAARD ,  Andreas BAUM ,  Joern Dalgaard MIKKELSEN

IPC: G01N21/3577 ,  G06F19/00 ,  G01N33/14 ,  C12Q1/37 ,  G01N33/04 ,  G01N21/75

CPC classification number: G01N21/3577 ,  C12Q1/37 ,  G01N21/1717 ,  G01N21/75 ,  G01N33/04 ,  G01N33/143 ,  G01N33/146 ,  G01N2201/127 ,  G01N2201/129 ,  G01N2333/9648 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70

Abstract: A method of determining a constituent related sample property of a multi-constituent sample comprising: subjecting the sample to a perturbation selected to induce a time dependent change in measurement data associated with a constituent related to the sample property to be determined; recording a time-series of measurement data following subjecting the sample to the perturbation; and determining the sample property from the application to the recorded time-series of measurement data of a calibration correlating the sample property with time-series of measurement data, said calibration being empirically derived from chemometric time-series modelling of time-series measurement data recorded for each of a plurality of reference samples following subjecting each reference sample to the perturbation, each reference sample having a different known values of the sample property.

公开(公告)号：US09625376B2

公开(公告)日：2017-04-18

申请号：US14772555

申请日：2013-03-22

Applicant: Foss Analytical A/S

Inventor： Maja Kirstine Elsoee ,  Henrik Vilstrup Juhl ,  Thomas Nikolajsen

IPC: G01J5/00 ,  G01N21/3563 ,  G01J3/443 ,  G01N33/24 ,  G01N21/35 ,  G01N21/71 ,  G01J3/28 ,  G01N1/28 ,  G01J1/08

CPC classification number: G01N21/3563 ,  G01J3/28 ,  G01J3/443 ,  G01J2001/083 ,  G01N1/286 ,  G01N21/35 ,  G01N21/718 ,  G01N33/24 ,  G01N2201/129

Abstract: A system (102) for determining properties of a sample (114) comprises a LIBS detector (104,106) and an infra-red absorption detector (108,110) for interrogating a sample (114) to generate LIBS spectral data and infra-red absorption spectral data respectively; and a data processor (112) adapted to apply at least one chemometric prediction model, each constructed to link, preferably quantitatively link, features of both LIBS and absorption spectral data to a different specific property of the sample, to a combined dataset derived from at least portions of both the LIBS and the absorption data to generate therefrom a determination, preferably a quantitative determination, of the specific property linked by that model.

公开(公告)号：US20150308971A1

公开(公告)日：2015-10-29

申请号：US14395686

申请日：2012-04-20

Applicant: Christer BISGAARD ,  Thomas LAURELL ,  Carl GRENVALL ,  Christian ANTFOLK

Inventor： Christer BISGAARD ,  Thomas LAURELL ,  Carl GRENVALL ,  Christian ANTFOLK

IPC: G01N27/02

CPC classification number: G01N27/02 ,  G01N15/12 ,  G01N2015/1062 ,  G01N2015/1236 ,  G01N2015/142

Abstract: A microfluidic impedance flow cytometer (‘MIC’) device (2) comprises a substrate (4) in which is formed at least one flow channel (6) for leading through a particle (22) containing fluidic sample. The flow channel (6) is formed with a focusing zone (12) and a measurement zone (14) located downstream of the focusing zone (12) in the direction of through flow and provided with an electrode arrangement (18) for characterising particles (22) in the flowing fluidic sample by means of electrical impedance wherein an acoustophoretic particle focusing arrangement (20) is provided in acoustic coupling to the flow channel (6) in the focusing zone (12) to induce acoustic forces in fluid in the flow channel (6) so as to effect a lateral and/or vertical focusing of particles before flowing to the measurement zone (14).

Abstract translation: 微流体阻流流式细胞仪（“MIC”）装置（2）包括衬底（4），其中形成有至少一个用于引导含有流体样品的颗粒（22）的流动通道（6）。 流动通道（6）形成有聚焦区域（12）和位于聚焦区域（12）的下游的测量区域（14），该测量区域沿着流动方向设置有用于表征颗粒的电极装置（18） 22）在流动的流体样品中通过电阻抗，其中在聚焦区域（12）中声学耦合到流道（6）提供声学粒子聚焦装置（20）以在流动通道中引起流体中的声力 （6），以便在流入测量区域（14）之前实现颗粒的横向和/或垂直聚焦。

公开(公告)号：US08593637B2

公开(公告)日：2013-11-26

申请号：US13583534

申请日：2012-04-26

Applicant: Jacob Riis Folkenberg ,  Hans Larsen

Inventor： Jacob Riis Folkenberg ,  Hans Larsen

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J3/45 ,  G01J3/4535

Abstract: A spectrometric instrument comprising: a scanning interferometer having a beamsplitter for dividing incident optical radiation into a reflected beam, following a reflected beam path and a transmitted beam following a transmitted beam path; a monochromatic optical radiation source for launching a reference beam into the interferometer along a first propagation path to be initially incident on a first face of the beamsplitter; an observation optical radiation source for launching a divergent observation beam into the interferometer along a second propagation path to be initially incident on the first face of beamsplitter and overlap the reference beam at the first face; wherein the radiation sources cooperate to generate a first angle between the directions of propagation of the two beams along respective first and second propagation paths when initially and simultaneously incident at the first face which is larger than a divergence half-angle of the observation beam 64.

Abstract translation: 一种光谱仪，包括：扫描干涉仪，具有分束器，用于将入射光辐射分成反射光束，跟随反射光束路径和发射光束跟随传输光束路径; 用于沿着第一传播路径将参考光束发射到干涉仪中以最初入射在分束器的第一面上的单色光辐射源; 观测光辐射源，用于沿着第二传播路径将发散观测光束发射到干涉仪中，以最初入射到分束器的第一面上，并在第一面处与参考光束重叠; 其中所述辐射源在最初并且同时入射在大于所述观察光束64的发散半角的所述第一面时在所述两个光束沿着相应的第一和第二传播路径的传播方向之间产生第一角度。

公开(公告)号：US20120218551A1

公开(公告)日：2012-08-30

申请号：US13505660

申请日：2009-12-10

Applicant: Christian Born

Inventor： Christian Born

IPC: G01N21/59

CPC classification number: G01N21/8507 ,  G01J3/51 ,  G01N21/0303 ,  G01N21/1702 ,  G01N29/2418

Abstract: A probe having a probe head in which is formed an opening for receiving a sample to be analysed, the head comprising a pair of optical interfaces disposed at an opposing inner surface of the opening to delimit a path for optical radiation through the opening, wherein one of the pair of optical interfaces comprises a transparent element adapted to permit optical radiation in one or more wavelength regions of interest to travel between the probe head and the opening, the optical probe comprising a movable diaphragm in which one of the pair of optical interfaces is located for movement therewith and an actuator operably connected to the diaphragm to control its movement so as to vary the path length wherein the probe head comprises a hinge system cooperable with the actuator to move the optical interface in the movable diaphragm in an arc to vary the path length.

Abstract translation: 具有探针头的探针形成有用于接收待分析样品的开口，所述头部包括一对光学界面，所述光学界面设置在所述开口的相对的内表面处以限定通过所述开口的光学辐射路径，其中一个 所述光学接口包括透明元件，所述透明元件适于允许在一个或多个感兴趣的波长区域内的光辐射在所述探针头和所述开口之间行进，所述光学探针包括可移动光阑，所述一对光学接口中的一个 所述致动器可操作地连接到所述隔膜以控制其运动，以便改变所述路径长度，其中所述探针头包括与所述致动器配合的铰链系统，以使所述可移动隔膜中的所述光学界面以弧形移动， 路径长度。

公开(公告)号：US20110154890A1

公开(公告)日：2011-06-30

申请号：US12737991

申请日：2008-10-08

Applicant: Claus Holm ,  Jacob Riis Folkenberg ,  Carl Johan Grenvall ,  Lars Thomas Laurell ,  Per Augustsson

Inventor： Claus Holm ,  Jacob Riis Folkenberg ,  Carl Johan Grenvall ,  Lars Thomas Laurell ,  Per Augustsson

IPC: G01N29/02

CPC classification number: B01D21/283 ,  B01L3/502761 ,  B01L2300/0816 ,  B01L2300/0877 ,  C12M47/06 ,  G01N15/12 ,  G01N15/1459 ,  G01N33/06

Abstract: The invention relates to a device for manipulation of particles (30) in a sample liquid (32) said device comprising a source of ultrasound (16) capable of emitting ultrasound with a given wavelength, an inlet for a sample liquid (2), one or more outlets (4, 5, 6) and a compartment (14), being dimensioned to support a standing ultrasonic wave (40) of said wavelength, characterised in that the device further comprises an inlet for sheath liquid (1, 3) configured to direct a sheath liquid (34) to extend substantially in parallel to an anti-node plane (46) of the ultrasonic standing wave (40) proximate to a sheathed compartment wall. Specifically the device may be used in combination with a particle enumeration device for enumeration of somatic cells in milk.

Abstract translation: 本发明涉及一种用于操纵样品液体（32）中的颗粒（30）的装置，所述装置包括能够发射具有给定波长的超声波的超声波源（16），用于样品液体的入口（2），一个 或多个出口（4,5,6）和隔室（14），其尺寸被设计成支撑所述波长的驻波超声波（40），其特征在于，所述装置还包括被配置成用于鞘液（1,3）的入口 引导护套液体（34）基本平行于邻近护套隔室壁的超声波驻波（40）的反节点平面（46）延伸。 具体地，该装置可以与用于计数牛奶中的体细胞的颗粒计数装置组合使用。

公开(公告)号：US07829339B2

公开(公告)日：2010-11-09

申请号：US12705889

申请日：2010-02-15

Applicant: Anders Broe Bendtsen ,  Poul Erik Petersen

Inventor： Anders Broe Bendtsen ,  Poul Erik Petersen

IPC: G01N33/04

CPC classification number: G01N21/82 ,  G01N15/042 ,  G01N21/3577 ,  G01N33/04

Abstract: The content of casein in milk is determined by two measurements of infrared absorbance in a milk sample by infrared spectrometry before and after a separation of the casein. The casein content is calculated by use of absorbance data recorded during the two absorbance measurements. The new method is considerable faster than the known wet-chemical methods, such as the normal wet chemical reference method for casein determination in milk using a Kjeldahl nitrogen determination of the milk sample, then a coagulation of the milk, and finally a Kjeldahl nitrogen determination of the filtrate. Further the new method provides a more reliable accuracy than the know determination using a single infrared analysis of a milk sample.

Abstract translation: 牛奶中酪蛋白的含量通过红外光谱法在酪蛋白分离前后通过乳样品中的红外吸光度的两次测量来确定。 通过使用在两次吸光度测量期间记录的吸光度数据来计算酪蛋白含量。 新方法比已知的湿法化学方法快得多，例如使用牛奶样品的凯氏定氮测定乳中酪蛋白测定的正常湿化学参考方法，然后凝乳，最后进行凯氏定氮 的滤液。 此外，新方法提供比使用牛奶样品的单一红外分析的知道确定更可靠的精度。