公开(公告)号：US20040073284A1

公开(公告)日：2004-04-15

申请号：US10618977

申请日：2003-07-14

申请人： Cook Incorporated ,  MED Institute, Inc. ,  WILLIAM COOK EUROPE ApS

发明人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

IPC分类号： A61F002/06

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

公开(公告)号：US20030216642A1

公开(公告)日：2003-11-20

申请号：US10146980

申请日：2002-05-16

发明人： Henry J. Pepin ,  Martin R. Willard ,  Pu Zhou ,  Greg Kampa

IPC分类号： A61B006/00 ,  A61M025/00

CPC分类号： A61L29/106 ,  A61L29/18 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter having an elongate shaft that is entirely non-magnetically responsive and at least partially radiopaque, including a reinforcement layer. The reinforcement layer may comprise a non-magnetically responsive radiopaque metal, such as a multi-strand Tungsten braid. The improved shaft of the present invention is compatible with x-ray and MRI visualization techniques, and may be incorporated into a wide variety of intravascular catheters such as guide catheters, diagnostic catheters, balloon catheters, etc.

摘要翻译： 一种血管内导管，其具有完全非磁性响应且至少部分不透射线的细长轴，包括加强层。 加强层可以包括非磁性响应的不透射线的金属，例如多股钨丝编织物。 本发明的改进的轴与x射线和MRI可视化技术兼容，并且可以并入多种血管内导管，例如导向导管，诊断导管，球囊导管等。

公开(公告)号：US06623823B1

公开(公告)日：2003-09-23

申请号：US09224463

申请日：1998-12-31

申请人： Fidelis C. Onwumere

发明人： Fidelis C. Onwumere

IPC分类号： A61F204

CPC分类号： C08G18/381 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L29/085 ,  A61L29/18 ,  A61L31/06 ,  A61L31/10 ,  A61L31/18 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/31554 ,  C08L75/04

摘要： An apparatus and method to produce radiopaque medical implants such as catheters, stents, or other implants. A composition of a radiopaque brominated polyurethane coat and a polyurethane tubing core is formed. In one embodiment, the polyurethane coat includes a diisocyanate and a brominated diol having a bromine concentration of 30% or more. The coat is applied to the elastomeric polyurethane tubing core surface. The medical implant takes advantage of employing a brominated radiopaque polyurethane with the tensile properties, for example of flexibility and kink resistance, of the elastomeric thermoplastic polyurethane tubing core without degrading these desirable characteristics.

摘要翻译： 用于产生不透射线的医疗植入物如导管，支架或其它植入物的装置和方法。 形成不透射线的溴化聚氨酯涂层和聚氨酯管芯的组合物。 在一个实施方案中，聚氨酯涂层包括二异氰酸酯和溴浓度为30％以上的溴化二醇。 将涂层施加到弹性聚氨酯管芯表面。 医疗植入物利用使用溴化不透射线的聚氨酯，其具有弹性体热塑性聚氨酯管芯的拉伸性能，例如柔韧性和抗扭结性，而不会降低这些所需的特性。

公开(公告)号：US06574497B1

公开(公告)日：2003-06-03

申请号：US09746843

申请日：2000-12-22

申请人： Stephen Dirk Pacetti

发明人： Stephen Dirk Pacetti

IPC分类号： A61M2500

CPC分类号： G01R33/285 ,  A61B90/39 ,  A61B2090/3954 ,  A61F2/01 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/075 ,  A61L29/18 ,  A61L31/18 ,  A61M25/0127

摘要： Medical devices that incorporate compounds containing fluorine-19 materials for use as contrast agents and passive markers in interventional magnetic resonance angiography. The device may be a guidewire, guiding catheter, angioplasty catheter, stent, embolic protection device, endovascular graft, endotracheal tube, Foley catheter, Hickman catheter, Broviac catheter, cerebrospinal fluid shunt, biliary stent, stylet, biopsy needle, electrode, percutaneous or endoluminal transducer or other desired interventional medical device. The fluorine-19 material may be configured from an elastomer, a fluid, a fluorosilicone, or a perfluorocarbon grease or oil. Such materials may be incorporated into marker bands and/or stripes, or may be deposited into or dispersed within the walls or lumens of the medical device to be visualized. Use of fluorine-19 containing markers and contrast agents provide a novel method of performing angioplasty and deploying stents, grafts, embolic protection and other such devices using interventional magnetic resonance angiography.

摘要翻译： 包含氟-19材料的化合物的医疗装置用作介入性磁共振血管造影剂中的造影剂和被动标记物。 该装置可以是导丝，引导导管，血管成形术导管，支架，栓塞保护装置，血管内移植物，气管内导管，Foley导管，Hickman导管，Broviac导管，脑脊液分流，胆管支架，探针，活检针，电极，经皮或 腔内换能器或其他所需的介入医疗装置。 氟-19材料可以由弹性体，流体，氟硅氧烷或全氟化碳润滑脂或油构成。 这样的材料可以并入到标记带和/或条纹中，或者可以沉积到或分散在待显现的医疗装置的壁或腔内。 使用含氟-19的标记物和造影剂提供了使用介入磁共振血管造影术进行血管成形术和部署支架，移植物，栓塞保护和其它这样的装置的新方法。

公开(公告)号：US20030100829A1

公开(公告)日：2003-05-29

申请号：US09995528

申请日：2001-11-27

发明人： Sheng-Ping Zhong ,  Ronald A. Sahatjian

IPC分类号： A61B005/05

CPC分类号： A61L29/18 ,  A61L31/18

摘要： The present invention relates to an elongated medical device for intralumenal manipulation during a process of magnetic resonance imaging. The device includes an elongated body. An extrusion material is integrated with the elongated body and includes a hydrophilic polymer that incorporates a substance having a plurality of paramagnetic ions. The extrusion material is configured to enhance magnetic resonance visibility during said process of magnetic resonance imaging.

摘要翻译： 本发明涉及一种用于在磁共振成像过程中进行腔内操作的细长医疗装置。 该装置包括细长体。 挤出材料与细长体结合在一起并且包括含有具有多个顺磁离子的物质的亲水聚合物。 挤出材料构造成在磁共振成像的所述过程期间增强磁共振可见度。

公开(公告)号：US5908410A

公开(公告)日：1999-06-01

申请号：US734273

申请日：1996-10-21

申请人： Jan Weber ,  Christianus J. G. Bakker

发明人： Jan Weber ,  Christianus J. G. Bakker

IPC分类号： A61L29/18 ,  A61M25/01 ,  A61M25/095 ,  G01R33/28 ,  A61M25/00

CPC分类号： G01R33/285 ,  A61L29/18 ,  A61M25/0127

摘要： A medical device, such as a medical catheter, having an imaging marker integral with the wall of the catheter but of a configuration such that the outer dimensions of the imaging marker remain substantially the same when the catheter is viewed along an x-axis, a y-axis and a z-axis to thereby present an image of substantially the same brightness regardless of the viewing angle.

摘要翻译： 一种医疗装置，例如医疗导管，其具有与导管的壁成一体的成像标记，但是具有这样的构造，使得当沿x轴观察导管时，成像标记的外部尺寸保持基本相同， y轴和z轴，从而呈现基本上相同亮度的图像，而不管视角如何。

公开(公告)号：US5820918A

公开(公告)日：1998-10-13

申请号：US679608

申请日：1996-07-11

申请人： John M. Ronan ,  Samuel A. Thompson

发明人： John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61L27/50 ,  A61L27/54 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61M25/00 ,  B05D1/18 ,  B05D1/36 ,  B05D7/24

CPC分类号： A61L27/54 ,  A61L27/50 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  Y10S623/924

摘要： A process for impregnating a medical device made from a water absorbable polymer material, e.g., a hydrogel, with a medical compound having low solubility in aqueous solutions, e.g., an antiseptic or radiopaque compound, is disclosed. The device is first infiltrated with an aqueous solution containing a first water soluble, ionizable compound, and subsequently infiltrated with an aqueous solution containing a second water soluble, ionizable compound. The ionizable compounds are selected such that they react after mutual contact to form the medical compound in-situ within the device.

摘要翻译： 公开了一种浸渍由可吸水聚合物材料（例如水凝胶）制成的医疗装置与在水溶液中具有低溶解度的医药化合物例如防腐剂或不透射线化合物的方法。 该装置首先用含有第一水溶性可电离化合物的水溶液渗透，随后用含有第二水溶性可电离化合物的水溶液渗透。 选择可电离化合物使得它们在相互接触之后反应以在装置内原位形成医用化合物。

公开(公告)号：US11919222B2

公开(公告)日：2024-03-05

申请号：US17741808

申请日：2022-05-11

申请人： CLEARSTREAM TECHNOLOGIES LIMITED

发明人： Paul Fillmore ,  Allan Ronan ,  Eoin Ryan ,  Andrew Schaffer

IPC分类号： B29C49/22 ,  A61L29/18 ,  A61M25/10 ,  B29C49/00 ,  B29D22/02 ,  B29L31/00

CPC分类号： B29C49/22 ,  A61L29/18 ,  A61M25/10 ,  A61M25/1027 ,  A61M25/1029 ,  B29C49/0005 ,  B29D22/02 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1079 ,  A61M2025/1086 ,  B29C2049/222 ,  B29L2031/753 ,  B29L2031/7543 ,  B32B2535/00

摘要： A parison for being blow molded into a medical balloon for a catheter includes a first tubular layer having a functional modification and a second tubular layer adapted for bonding with the first tubular layer to form the blow molded balloon. Related methods are also disclosed.

公开(公告)号：US20230233742A1

公开(公告)日：2023-07-27

申请号：US18010653

申请日：2021-06-18

申请人： SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.

发明人： Meng LI ,  Yufu WANG ,  Junfei LI ,  Yan HU

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L29/14 ,  A61L29/18

CPC分类号： A61L29/16 ,  A61L29/085 ,  A61L29/146 ,  A61L29/143 ,  A61L29/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2400/12 ,  A61L2300/608

摘要： A drug-loaded medical device, a preparation method therefor, a drug balloon and a method of preparing a drug coating are disclosed. The medical device or the drug balloon is provided on a surface thereof with a drug coating including a stabilizer and a drug. The stabilizer includes an amphiphilic triblock polymer with hydrophilic segments at both terminals, and the drug coating forms a nano-drug particle suspension in a water-soluble environment. In this way, the prepared nano-drug coating has high drug loading and can deliver the drug in a desirable way. In particular, when it comes into contact with water, the drug can be restored to the original nano size, almost without any particle size increase. This not only avoids the risk of embolism caused by granules, but also enables higher device safety, increased drug uptake and improved therapeutic effects.

公开(公告)号：US20180140806A1

公开(公告)日：2018-05-24

申请号：US15850938

申请日：2017-12-21

申请人： Prytime Medical Devices, Inc.

发明人： Curtis J. FRANKLIN

IPC分类号： A61M25/10 ,  A61L29/04 ,  A61L29/06 ,  C08L77/12 ,  A61M25/00 ,  A61L29/02 ,  A61L29/18

CPC分类号： A61M25/1006 ,  A61L29/02 ,  A61L29/04 ,  A61L29/06 ,  A61L29/18 ,  A61L2400/16 ,  A61M25/0068 ,  A61M25/008 ,  A61M2025/0002 ,  A61M2025/1079 ,  C08L77/12

摘要： A low profile occlusion catheter having a guiding atraumatic tip that prevents entry of the balloon into collateral vessels. The occlusion catheter system is particularly well suited for use in vascular occlusion and includes a pressure monitoring line to monitor the degree and state of occlusion.