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    Blood compatible polymers and medical devices made therefrom
    53.
    发明授权
    Blood compatible polymers and medical devices made therefrom 失效
    与血液相容的聚合物和由此制成的医疗器械

    公开(公告)号：US4300559A

    公开(公告)日：1981-11-17

    申请号：US151448

    申请日：1980-05-19

    申请人： Henry M. Gajewski ,  Paul E. Measells

    发明人： Henry M. Gajewski ,  Paul E. Measells

    IPC分类号： A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  A61M5/00

    CPC分类号： A61J1/10 ,  A61L33/0005 ,  A61L33/0052 ,  A61M1/3687 ,  C08K5/12 ,  Y10S128/24

    摘要： Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

    摘要翻译： 与血液相容的无氯聚合物如柔性无毒的可灭菌的聚酯塑料制剂可含有5-70重量％的血液可提取增塑剂，例如邻苯二甲酸二-2-乙基己基酯，以引起储存的血液 与不含增塑剂的相应聚合物相比，与聚合物接触以显示惊人的低溶血速率。 因此，可以有利地由这些聚合物制造血袋，管道和其它医用血液接触装置。

    Method for preparation of biocompatible and biofunctional materials and product thereof
    55.
    发明授权
    Method for preparation of biocompatible and biofunctional materials and product thereof 失效
    生物化学和生物功能材料的制备方法及其制备方法

    公开(公告)号：US3826678A

    公开(公告)日：1974-07-30

    申请号：US26023772

    申请日：1972-06-06

    申请人： ATOMIC ENERGY COMMISSION

    发明人： HOFFMAN A ,  SCHMER G

    IPC分类号： C08F8/00 ,  A61L27/14 ,  A61L33/00 ,  C08B37/10 ,  C08J7/00 ,  C12N11/02 ,  C12N11/08 ,  A61K17/18 ,  A61K23/02

    CPC分类号： C08B37/0075 ,  A61L27/14 ,  A61L33/0005 ,  A61L33/0029 ,  A61L33/0047 ,  C08J7/12 ,  C08J2375/04 ,  C12N11/08 ,  Y10S623/92 ,  Y10T428/31504 ,  Y10T428/31536

    摘要： A METHOD FOR THE PREPARATION OF BIOCOMPATIBLE AND BIOFUNCTIONAL SURFACES IS PROVIDED BIOCOMPATIBLE AND
    ATI N GRAFTING A REACTABLE COMPOUND SELECTED FROM THE GROU CONSISTING OF POLYMERS AND COPOLYMERS ONTO AN INERT UP
    POL MERIC SUBSTRATE AND THEREAFTER CHEMICALLY BONDING A BIOLOGICALLY ACTIBE MOLECULE TO THE REATABLE COMPOUND SPECIFIC EMBODMENTS INCLUDE CHEMICALLY BONDING OF HUMAN SERUM ALBUMIN HEPARIN, STREPTOKINASE, PROSTAGLANDIN E-1 AND MIXTURES THEREOF TO HYDROGELS OF VARYING COMPOSITIONS WITH OR WITHOUT "ARM" SUC AS E-AMINO CAPROIC MOLECULE OR CHEMICAL "ARM" SUCAN INTERMEDIATE SMALLER ACID OR 1,4 DIAMINO BUTANE, THE HYDROGELS HAING BEEN PREVIOUSLY RADIATION-GRAFTED TO TOUGH INERT POLYMERIC SUBSTRATE. A HIGHLY SYNERGISTIC EFFECT IS ACHIEVED FOR HYDROGELS CONTAINING HIGH WATER CONTENT E.G., ABOVE ABOUT 55% WHEN THE CHEMICALLY BONDING OF THE BIOLOGICALLY ACTIVE MOLECULE IS CARRIED OUT VIA AN INTERMEDIATE SMALLER MOLECULE OR CHEMICALL ARM. FOR THIN FILM SUBSTRATES HAVING RAIATION-GRAFTED THERETO HYDROGELS WITH -CO2 PENDANT FUNCTIONAL GROUPS WHICH ARE ACTIVATED WITH A CARBODIIMIDE SOLUTION A QUICK WASH OF THE THIN FILM WITH ICE WATER IS REQUIRED TO EFFECT SUBSEQUENT CHEMICAL BONDING OF THE BIOLOGICALLY ACTIVE MOLECULES TO THE ACTIVATED SURFACE. THE SAME TECHNIQUE IS ALSO REQUIRED WHERE A CHEMICAL ARM IS EMPLOYED WHICH HAS -CO2H PENDANT FUNCTIONAL GROUPS.

    CHARGED GRAFTS AND METHODS FOR USING THEM
    60.
    发明申请
    CHARGED GRAFTS AND METHODS FOR USING THEM 审中-公开
    收费及其使用方法

    公开(公告)号：US20120185033A1

    公开(公告)日：2012-07-19

    申请号：US13431933

    申请日：2012-03-27

    申请人： Timothy J. Ryan

    发明人： Timothy J. Ryan

    IPC分类号： A61F2/82 ,  A61N1/00

    CPC分类号： A61L33/0005 ,  A61F2/06 ,  A61F2/07 ,  A61F2/2403 ,  A61F2/89 ,  A61F2002/075 ,  A61F2220/0075 ,  A61L27/34 ,  A61L27/50 ,  A61L27/507 ,  A61L29/085 ,  A61L29/14 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3659 ,  A61M1/3661 ,  A61N1/20 ,  A61N1/205

    摘要： A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.

    摘要翻译： 用于防止可植入医疗装置中的血栓形成的系统包括可植入医疗装置，其尺寸适于至少部分地植入患者体内。 该装置包括至少部分导电部分，其在植入时设置在患者体内，电极，耦合到该装置的导电部分; 以及耦合到所述电极的电源。 电源在至少部分导电部分提供负电荷，持续无限期的时间。 该装置可以被配置为一旦植入就经由带电的导电部分抵抗血栓形成，感染和/或不想要的组织生长。 可植入医疗装置的示例性实施例包括血液透析脉管系统移植物，透析导管，冠状动脉和心脏瓣膜。