PREPARATION OF PHENOL-FORMALDEHYDE RESIN BEADS USING SUSPENSION OR EMULSION POLYMERIZATION
    53.
    发明申请
    PREPARATION OF PHENOL-FORMALDEHYDE RESIN BEADS USING SUSPENSION OR EMULSION POLYMERIZATION 有权
    使用悬浮或乳液聚合制备酚醛树脂珠粒

    公开(公告)号:US20140148560A1

    公开(公告)日:2014-05-29

    申请号:US14092267

    申请日:2013-11-27

    Abstract: Methods for making polymer particles in gel form via an emulsion and/or suspension polymerization are provided. In at least one specific embodiment, the method can include reacting a first reaction mixture comprising a phenolic monomer, an aldehyde monomer, and a first catalyst to produce a prepolymer. The method can also include combining the prepolymer with a carrier fluid and a second catalyst to produce a second reaction mixture. The second catalyst can include a dicarboxylic acid, an anhydride, a dihydroxybenzene, or any mixture thereof. The method can also include polymerizing the prepolymer to form polymer particles in gel form.

    Abstract translation: 提供了通过乳液和/或悬浮聚合制备凝胶形式的聚合物颗粒的方法。 在至少一个具体实施方案中,该方法可以包括使包含酚单体,醛单体和第一催化剂的第一反应混合物反应以产生预聚物。 该方法还可以包括将预聚物与载体流体和第二催化剂组合以产生第二反应混合物。 第二催化剂可以包括二羧酸,酸酐,二羟基苯或其任何混合物。 该方法还可包括聚合预聚物以形成凝胶形式的聚合物颗粒。

    PROCESS FOR PREPARING POROUS POLYMER PARTICLES
    55.
    发明申请
    PROCESS FOR PREPARING POROUS POLYMER PARTICLES 有权
    制备多孔聚合物颗粒的方法

    公开(公告)号:US20130165541A1

    公开(公告)日:2013-06-27

    申请号:US13334199

    申请日:2011-12-22

    Abstract: A process for forming polymer particles with aligned pores and controlled narrow particle size distribution, including: a) forming an oil phase by dissolving a polymeric binder in a solvent; b) dispersing the oil phase into a water phase containing a controlled amount of particulate stabilizer and forming an oil-in-water emulsion of controlled narrow dispersed oil phase droplet size distribution; c) freezing the emulsion to freeze solvent in the oil droplets to form frozen solvent domains within the polymeric binder, and also the water in the continuous water phase; and d) removing the frozen solvent from the polymeric binder and the frozen water in the continuous water phase, thereby forming porous polymer particles of controlled narrow particle size distribution and containing directional aligned non-spherical pore structures. Optionally, the porous particles may contain encapsulated functional ingredients.

    Abstract translation: 一种用于形成具有排列孔和受控的窄粒度分布的聚合物颗粒的方法,包括:a)通过将聚合物粘合剂溶解在溶剂中形成油相; b)将油相分散到含有受控量的颗粒稳定剂的水相中并形成受控窄分散油相液滴尺寸分布的水包油乳液; c)冷冻乳液以在油滴中冷冻溶剂,以在聚合物粘合剂内形成冷冻溶剂结构域,以及连续水相中的水; 以及d)从连续水相中的聚合物粘合剂和冷冻水中除去冷冻的溶剂,从而形成受控窄粒度分布的多孔聚合物颗粒并且包含定向排列的非球形孔结构。 任选地,多孔颗粒可以含有包封的功能性成分。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    60.
    发明授权
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有受控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号:US06610764B1

    公开(公告)日:2003-08-26

    申请号:US09218575

    申请日:1998-12-22

    Abstract: Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

    Abstract translation: 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中,聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中,聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中,聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如,如通过实施例所证明的,多孔聚羟基链烷酸酯可以使用产生孔,空隙或间隙的方法,例如乳液或喷雾干燥技术,或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫,涂层,网格和微粒的聚(4HB)组合物。 如实施例所示,这些聚羟基链烷酸酯组合物在生理条件下在期望的时间范围内具有非常有利的机械性能以及生物相容性和降解性。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法,特别是用于治疗,预防或诊断应用,或可植入或注射的装置。

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