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355 条记录 (耗时 0.03 秒)

    METHOD OF DIAGNOSING CHRONIC DIARRHEA
    51.
    发明申请
    METHOD OF DIAGNOSING CHRONIC DIARRHEA 审中-公开
    诊断慢性肾脏病的方法

    公开(公告)号：US20070141713A1

    公开(公告)日：2007-06-21

    申请号：US11613717

    申请日：2006-12-20

    申请人： Thomas Donndelinger

    发明人： Thomas Donndelinger

    IPC分类号： G01N33/48

    CPC分类号： G01N33/6848 ,  G01N33/6893 ,  G01N2333/4742 ,  G01N2800/06 ,  Y10T436/24

    摘要： A method for obtaining information about a chronic diarrhea condition in a patient, including possible diagnosis of chronic diarrhea, is disclosed. In the method, a sample of a gastrointestinal secretion that contains mitochondria is obtaining from the patient. The sample is analyzed using an analytical technique, such as mass spectroscopy, to obtain a unique proteomic pattern characteristic of the proteins within the secretion. The proteomic pattern of the sample is compared with a proteomic pattern profile database to determine differences and similarities of the proteomic pattern to the proteomic pattern profile database. The proteomic pattern database may include profiles of normal and/or abnormal proteomic patterns.

    摘要翻译： 公开了一种获得患者慢性腹泻病情信息的方法，包括慢性腹泻的可能诊断。 在该方法中，含有线粒体的胃肠道分泌物样品是从患者获得的。 使用分析技术（如质谱）分析样品，以获得分泌物内蛋白质的独特蛋白质组图谱特征。 将样品的蛋白质组学模式与蛋白质组学模型谱数据库进行比较，以确定蛋白质组学模式与蛋白质组学模式谱数据库的差异和相似性。 蛋白质组图案数据库可以包括正常和/或异常蛋白质组图案的概况。

    Agents for preventing and/or treating uppper digestive tract disorders
    55.
    发明申请
    Agents for preventing and/or treating uppper digestive tract disorders 审中-公开
    用于预防和/或治疗上消化道疾病的药剂

    公开(公告)号：US20070042947A1

    公开(公告)日：2007-02-22

    申请号：US10548817

    申请日：2004-03-11

    申请人： Hirokazu Matsumoto ,  Koh Takagi ,  Masaaki Mori

    发明人： Hirokazu Matsumoto ,  Koh Takagi ,  Masaaki Mori

    IPC分类号： A61K38/17

    CPC分类号： A61K38/177 ,  A61K38/1709 ,  C12N2310/11 ,  G01N2800/06

    摘要： A compound or its salts that inhibit the activity of the polypeptide or receptor of the present invention and the antibody of the present invention as well as the antisense DNA of the present invention are useful as, e.g., gastric acid secretion inhibitors, mucosa protectants, mineral absorption promoters, etc., which are less toxic and safe, and can be used as, e.g., agents for preventing/treating upper digestive tract disorders, antibacterial agents to Helicobacter pylori, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide or receptor of the present invention and the DNA of the present invention can be used as, e.g., gastric acid secretion promoters and can be used as, e.g., agents for preventing/treating dyspepsia, bone metabolism disorders, anemia, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide of the present invention, etc. can also be used as test agents for gastric secretory function. Furthermore, the polypeptide or receptor of the present invention and the DNA of the present invention are also useful for screening the agents for the prevention/treatment described above.

    摘要翻译： 抑制本发明的多肽或受体和本发明的抗体以及本发明的反义DNA的活性的化合物或其盐可用于例如胃酸分泌抑制剂，粘膜保护剂，矿物质 吸收促进剂等，其毒性和安全性较低，并且可以用作例如用于预防/治疗上消化道疾病的药剂，对幽门螺杆菌等的抗菌剂。促进幽门螺杆菌活性的化合物或其盐 本发明的多肽或受体，本发明的多肽或受体和本发明的DNA可以用作例如胃酸分泌促进剂，并且可以用作例如用于预防/治疗消化不良，骨骼的药剂 代谢紊乱，贫血等。促进本发明的多肽或受体的活性，本发明的多肽等的化合物或其盐。c 也可用作胃分泌功能的试剂。 此外，本发明的多肽或受体和本发明的DNA也可用于筛选用于上述预防/治疗的药剂。

    Differential gene expression in intestinal polyps
    58.
    发明申请
    Differential gene expression in intestinal polyps 审中-公开
    差异基因在肠息肉中的表达

    公开(公告)号：US20050153314A1

    公开(公告)日：2005-07-14

    申请号：US10961819

    申请日：2004-10-08

    申请人： David Graaf ,  Eric Lander

    发明人： David Graaf ,  Eric Lander

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  G01N33/68

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/06

    摘要： The present invention features method for identifying an intestinal polyp according to the gen expression profile obtained from intestinal tissue. The present invention also features methods for identifying a compound that modulates intestinal polyp development, as well as oligonucleotide microarrays having genes involved in intestinal polyp development immobilized thereon.

    摘要翻译： 本发明的特征在于根据从肠组织获得的基因表达谱来鉴定肠息肉的方法。 本发明还涉及用于鉴定调节肠息肉发展的化合物的方法，以及具有固定在其上的肠息肉发育参与的基因的寡核苷酸微阵列。

    Method for determining location of gastrointestinal bleeding
    59.
    发明授权
    Method for determining location of gastrointestinal bleeding 失效
    确定胃肠道出血位置的方法

    公开(公告)号：US06844195B2

    公开(公告)日：2005-01-18

    申请号：US09994143

    申请日：2001-11-26

    申请人： Brian L. Craine

    发明人： Brian L. Craine

    IPC分类号： G01N1/28 ,  G01N15/06 ,  G01N21/03 ,  G01N21/31 ,  G01N21/35 ,  G01N33/68 ,  G01N33/72

    CPC分类号： G01N33/6893 ,  G01N1/4077 ,  G01N15/0625 ,  G01N15/0631 ,  G01N21/03 ,  G01N21/31 ,  G01N21/35 ,  G01N33/72 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2800/06

    摘要： A method for determining if blood in a stool sample originated from the upper or lower gastrointestinal tract. This includes a method for purifying and concentrating hemoglobin and its products from a stool sample to allow a simple and sensitive spectrophotometric analysis. A rapid, noninvasive determination of whether the blood originated from an upper gastrointestinal or lower gastrointestinal site is made on the basis of changes in the absorption spectra of hemoglobin that occur when hemoglobin is exposed to a highly acidic environment.

    摘要翻译： 用于确定粪便样品中的血液是否源于上部或下部胃肠道的方法。 这包括从粪便样品中纯化和浓缩血红蛋白及其产物的方法，以便进行简单和敏感的分光光度分析。 基于当血红蛋白暴露于高度酸性环境时发生的血红蛋白的吸收光谱的变化，快速，无创测定是否来自上消化道或下胃肠道部位的血液。