公开(公告)号：US20220089652A1

公开(公告)日：2022-03-24

申请号：US17450348

申请日：2021-10-08

申请人： Janssen Vaccines & Prevention B.V.

发明人： Anders KRARUP ,  Johannes Petrus Maria LANGEDIJK

IPC分类号： C07K14/135 ,  A61K39/12 ,  C07K14/005 ,  A61P31/14 ,  C07K16/10 ,  C12N15/62

摘要： Stable pre-fusion respiratory syncytial virus (RSV) F proteins (or fragment thereof) are described. Compositions containing the proteins and uses of the compositions for the prevention and/or treatment of RSV infection are also described.

公开(公告)号：US11155583B2

公开(公告)日：2021-10-26

申请号：US16091344

申请日：2017-04-04

申请人： Janssen Vaccines & Prevention B.V.

发明人： Anders Krarup ,  Johannes Petrus Maria Langedijk

IPC分类号： A61K39/12 ,  C07K14/135 ,  C07K14/005 ,  A61P31/14 ,  C07K16/10 ,  C12N15/62 ,  A61K39/00

摘要： Stable pre-fusion respiratory syncitial virus (RSV) F proteins (or fragment thereof) are described. Compositions containing the proteins and uses of the compositions for the prevention and/or treatment of RSV infection are also described.

公开(公告)号：US20210300971A1

公开(公告)日：2021-09-30

申请号：US16964118

申请日：2019-01-24

申请人： Merck Sharp & Dohme Corp.

发明人： Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

IPC分类号： C07K14/135 ,  A61K39/155 ,  C12N7/00

摘要： The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.

公开(公告)号：US11027007B2

公开(公告)日：2021-06-08

申请号：US16578748

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  C07K14/115 ,  A61K39/39 ,  C07K14/005 ,  A61K48/00 ,  C07K14/135

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20210101940A1

公开(公告)日：2021-04-08

申请号：US17126128

申请日：2020-12-18

申请人： Janssen Vaccines & Prevention B.V.

发明人： Johannes Petrus Maria Langedijk ,  Anders Krarup

IPC分类号： C07K14/005 ,  A61K39/155 ,  C07K14/135 ,  A61K39/12 ,  C12N7/00

摘要： Described are stable pre-fusion respiratory syncitial virus (RSV) F polypeptides, immunogenic compositions comprising the polypeptides and uses thereof for the prevention and/or treatment of RSV infection.

公开(公告)号：US10744193B2

公开(公告)日：2020-08-18

申请号：US15562862

申请日：2016-02-18

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Surender Khurana ,  Hana Golding

IPC分类号： A61K39/12 ,  C07K14/135 ,  A61P31/14 ,  C12N7/00 ,  G01N33/569 ,  A61K39/00

摘要： This invention provides immunogenic compositions comprising an immune stimulant and an respiratory syncytial virus (RSV) oligopeptide or an unglycosylated RSV polypeptide. The RSV oligopeptides are shown in SEQ ID NO: 3-33. The unglycosylated RSV polypeptide may consist essentially of the ectodomain of an RSV G protein, such as that shown in SEQ ID NO: 2 or the ectodomain of an RSV F protein such as the ectodomain of the F protein shown in SEQ ID NO: 39.

公开(公告)号：US20190055291A1

公开(公告)日：2019-02-21

申请号：US16081431

申请日：2017-03-02

申请人： FONDATION THE ARK

发明人： ORIGENE NYANGUILE ,  JEAN-MANUEL SEGURA ,  DOMINIQUE GARCIN

IPC分类号： C07K14/135 ,  A61K38/16 ,  A61P31/14

摘要： The present invention relates novel peptides useful for the prevention and/or treatment of respiratory syncytial virus (RSV) infections.

公开(公告)号：US20130136759A1

公开(公告)日：2013-05-30

申请号：US13763822

申请日：2013-02-11

申请人： The Government of the United States of America being represented by the Secretary of the Department

发明人： Larry J. Anderson ,  Lia M. Haynes ,  Ralph A. Tripp

IPC分类号： C07K14/135

CPC分类号： C07K14/135 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/555 ,  A61K2039/55505 ,  A61K2039/6081 ,  C07K14/005 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogues thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogues thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogues thereof.

摘要翻译： 对应于一种或多种RSV G糖蛋白或其类似物的免疫原性多肽作为疫苗的组分提供。 本发明的组合物既可用于预防和治疗RSV感染及相关肺或其他疾病。 本发明的免疫原包括RSV G蛋白的区域，特别是RSV G A2蛋白的氨基酸残基164-176或其类似物。 本发明的免疫原可单独使用或与其它多肽如RSV G蛋白氨基酸残基155-206或其它疫苗例如活RSV疫苗或灭活的RSV疫苗或其免疫原性类似物一起使用。

公开(公告)号：US20110305727A1

公开(公告)日：2011-12-15

申请号：US12836931

申请日：2010-07-15

申请人： Kurt Swanson ,  Philip R. Dormitzer

发明人： Kurt Swanson ,  Philip R. Dormitzer

IPC分类号： A61K39/155 ,  C07H21/04 ,  A61P37/04 ,  C07K14/135

CPC分类号： C07K16/1027 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K14/005 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/36143

摘要： The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

摘要翻译： 本发明涉及包含RSV F蛋白的免疫原性组合物，用于制备含有RSV F蛋白质外结构域多肽的组合物的方法，以及编码经工程化的RSV F蛋白的某些工程改造的RSV F蛋白和核酸。 使用该方法制备的组合物可以含有主要或单一所需形式和构象的RSV F蛋白质外结构域多肽。 本发明还涉及诱导对RSV F的免疫应答的方法。

公开(公告)号：US20100291680A1

公开(公告)日：2010-11-18

申请号：US12791983

申请日：2010-06-02

申请人： Dani Paul Bolognesi ,  Thomas James Matthews ,  Carl T. Wild ,  Shawn O'Lin Barney ,  Dennis Michael Lambert ,  Stephen Robert Petteway, JR. ,  Alphonse J. Langlois

发明人： Dani Paul Bolognesi ,  Thomas James Matthews ,  Carl T. Wild ,  Shawn O'Lin Barney ,  Dennis Michael Lambert ,  Stephen Robert Petteway, JR. ,  Alphonse J. Langlois

IPC分类号： C12N5/02 ,  C07K14/005 ,  C07K14/16 ,  C07K14/155 ,  C07K14/135 ,  C07K14/115 ,  C07K14/02 ,  C07K14/11 ,  C07K14/05

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/525 ,  A61K2039/555 ,  A61K2039/60 ,  A61K2039/6031 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/0819 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1016 ,  C07K5/1021 ,  C07K5/1024 ,  C07K14/21 ,  C07K14/22 ,  C07K14/245 ,  C07K14/285 ,  C07K14/31 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16222 ,  C12N2730/10122 ,  C12N2740/13022 ,  C12N2740/14022 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/17022 ,  C12N2760/16122 ,  C12N2760/18022 ,  C12N2760/18122 ,  C12N2760/18422 ,  C12N2760/18522 ,  C12N2760/18622 ,  C12N2760/18722 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/505 ,  G01N33/5091 ,  Y10S530/826

摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.

摘要翻译： 本发明涉及显示出有力的抗​​逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID NO：1）肽以及DP178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。