公开(公告)号：US08623322B2

公开(公告)日：2014-01-07

申请号：US12991253

申请日：2009-06-15

Applicant: Jeffrey P. Norenberg

Inventor： Jeffrey P. Norenberg

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K51/0453 ,  A61K31/4178 ,  A61K51/00 ,  A61K51/044 ,  A61K51/0497 ,  G01N33/569 ,  G01N2333/70525 ,  G01N2333/70553 ,  Y02A50/47 ,  Y02A50/481

Abstract: The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.

Abstract translation: 本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。 本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。 该新型成像探针能够检测感染的细胞以及组织。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。 还描述了药物组合物。

公开(公告)号：US08623192B2

公开(公告)日：2014-01-07

申请号：US13125096

申请日：2009-10-20

Applicant: Sang M. Han ,  Youn-Jin Oh ,  Cornelius Ivory

Inventor： Sang M. Han ,  Youn-Jin Oh ,  Cornelius Ivory

IPC: B03C5/02

CPC classification number: G01N33/6803 ,  G01N27/414 ,  G01N27/4473 ,  G01N27/44795

Abstract: Exemplary embodiments provide systems and methods for concentrating, focusing and/or separating proteins using nanofluidic channels and/or their arrays. In embodiments, low-abundance proteins can be focused and separated with high resolution using separation techniques including isoelectric focusing (IEF), and/or dynamic field gradient focusing (DFGF) in combination with nanofluidic channels and/or multi-gate nanofluidic field-effect-transistors (FETs).

Abstract translation: 示例性实施方案提供用于使用纳米流体通道和/或其阵列浓缩，聚焦和/或分离蛋白质的系统和方法。 在实施方案中，可以使用包括等电聚焦（IEF）和/或动态场梯度聚焦（DFGF）与纳流感通道和/或多栅极纳米流体场效应的分离技术以高分辨率聚焦和分离低丰度蛋白质 晶体管（FET）。

公开(公告)号：US08610454B2

公开(公告)日：2013-12-17

申请号：US13513941

申请日：2011-01-12

Applicant: James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

Inventor： James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

IPC: H03K19/00 ,  H05K3/00

CPC classification number: H04L9/0861 ,  G06F21/73 ,  G09C1/00 ,  H04L9/0866 ,  Y04S40/24 ,  Y10T29/49124

Abstract: A system and methods that generates a physical unclonable function (“PUF”) security key for an integrated circuit (“IC”) through use of equivalent resistance variations in the power distribution system (“PDS”) to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

Abstract translation: 通过使用配电系统（“PDS”）中的等效电阻变化，为集成电路（“IC”）生成物理不可克隆功能（“PUF”）安全密钥以减轻安全密钥的漏洞的系统和方法 威胁包括克隆，盗用和未经授权的使用。

公开(公告)号：US08557119B1

公开(公告)日：2013-10-15

申请号：US12880359

申请日：2010-09-13

Applicant: Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

Inventor： Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

IPC: B01D61/58 ,  B01D61/02 ,  B01D15/04 ,  B01D59/30

CPC classification number: B01D61/04 ,  B01D61/025 ,  B01D2311/04 ,  B01D2311/2623 ,  B01D2317/022 ,  C02F1/42 ,  C02F1/441 ,  C02F1/4693 ,  C02F9/00 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2103/08 ,  Y02A20/131 ,  Y02A20/134

Abstract: A novel method for improving water recovery from desalination systems by the removal of cations and/or anions using ion exchange (IX) technology. The system described herein is particularly useful for water recovery in brackish ecosystems and is unique in that important features include recycling, regeneration, and recovery of key components, thereby reducing costs and waste products.

Abstract translation: 一种通过使用离子交换（IX）技术去除阳离子和/或阴离子来改善脱盐系统的水回收的新方法。 本文描述的系统特别适用于微咸水生态系统中的水回收，并且是独特的，因为重要特征包括关键组分的回收，再生和回收，从而降低成本和废物。

公开(公告)号：US20130193065A1

公开(公告)日：2013-08-01

申请号：US13831537

申请日：2013-03-14

Applicant: Steven R.J. Brueck ,  Deying Xia ,  Yuliya Kuznetsova ,  Alexander Neumann

Inventor： Steven R.J. Brueck ,  Deying Xia ,  Yuliya Kuznetsova ,  Alexander Neumann

IPC: B01D69/04 ,  G03F7/20

CPC classification number: B01D69/04 ,  B81C1/00071 ,  B82Y30/00 ,  G03F7/2051 ,  Y10S977/78 ,  Y10S977/84 ,  Y10T137/0324 ,  Y10T137/3006

Abstract: In accordance with the invention, there is a method of forming a nanochannel including depositing a photosensitive film stack over a substrate and forming a pattern on the film stack using interferometric lithography. The method can further include depositing a plurality of silica nanoparticles to form a structure over the pattern and removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises an enclosed nanochannel.

Abstract translation: 根据本发明，存在一种形成纳米通道的方法，其包括在衬底上沉积感光膜堆叠并且使用干涉光刻在膜堆上形成图案。 该方法可以进一步包括沉积多个二氧化硅纳米颗粒以在图案上形成结构并除去图案，同时保留由多个二氧化硅纳米颗粒形成的结构，其中该结构包括封闭的纳米通道。

公开(公告)号：US08454513B2

公开(公告)日：2013-06-04

申请号：US11320921

申请日：2005-12-30

Applicant: Jingkuang Chen ,  Xiaoyang Cheng

Inventor： Jingkuang Chen ,  Xiaoyang Cheng

IPC: A61B1/12

CPC classification number: A61M37/00

Abstract: A medical device may include a micro-machined substrate, at least one thermo-electric assembly associated with the substrate, and a cooling system configured to configured to remove heat from the a region of the substrate proximal the substrate. According to various aspects, a method of clearing plaque from a blood vessel may include implanting a micro-device in the blood vessel, wherein the micro-device may include at least one ultrasonic transducer, and operably controlling the micro-device to emit high frequency ultrasonic waves for breaking up said plaque.

Abstract translation: 医疗装置可以包括微加工衬底，与衬底相关联的至少一个热电组件以及被配置为从靠近衬底的衬底的区域移除热量的冷却系统。 根据各个方面，从血管清除斑块的方法可以包括将微器件植入血管中，其中微器件可以包括至少一个超声换能器，并且可操作地控制微器件发射高频 超声波破碎所述斑块。

公开(公告)号：US08445537B2

公开(公告)日：2013-05-21

申请号：US12576410

申请日：2009-10-09

Applicant: Alan E. Tomkinson ,  Xi Chen ,  Barbara Dziegielewska ,  Alexander D. Mackerell ,  Shijun Zhong ,  Gerald M. Wilson

Inventor： Alan E. Tomkinson ,  Xi Chen ,  Barbara Dziegielewska ,  Alexander D. Mackerell ,  Shijun Zhong ,  Gerald M. Wilson

IPC: A61K31/16 ,  A61K31/13

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/166 ,  A61K31/175 ,  A61K31/255 ,  A61K31/341 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/553 ,  A61K45/06 ,  A61N5/10 ,  C07D209/30 ,  C07D235/28 ,  C07D257/04 ,  C07D263/58 ,  C07D267/18 ,  C07D271/12 ,  C07D277/74 ,  C07D285/14 ,  C07D307/68 ,  C07D401/12 ,  C07D407/12 ,  C40B30/02 ,  G01N21/64 ,  G06F19/16 ,  G06F19/706

Abstract: Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.

公开(公告)号：US08426489B1

公开(公告)日：2013-04-23

申请号：US12638566

申请日：2009-12-15

Applicant: Marwan S. Al-Haik ,  Tariq A. Khraishi

Inventor： Marwan S. Al-Haik ,  Tariq A. Khraishi

IPC: A61L24/02 ,  A61K6/083 ,  A61C13/087 ,  A61C5/09 ,  A61C5/10 ,  A61C5/11

CPC classification number: A61L27/50 ,  A61L27/443 ,  A61L27/446 ,  A61L2400/12 ,  A61L2430/12

Abstract: Present embodiments include composite dental materials for use in fillings and crowns, and methods of making the same. The composite materials can include biocompatible dental resin matrices and filler materials. The filler materials can include various types of magnetic nanoparticles. Additional embodiments include method of forming composite dental materials using a magnetic field and methods for forming aluminum oxide (Al2O3) nanoparticles. Other embodiments according to present teachings include methods for filling dental cavities and forming dental crowns.

Abstract translation: 现有实施例包括用于填充物和牙冠的复合牙科材料及其制造方法。 复合材料可以包括生物相容的牙科树脂基质和填充材料。 填充材料可以包括各种类型的磁性纳米颗粒。 另外的实施方案包括使用磁场形成复合牙科材料的方法和形成氧化铝（Al 2 O 3）纳米颗粒的方法。 根据本教导的其他实施例包括用于填充牙腔和形成牙冠的方法。

公开(公告)号：US08334013B2

公开(公告)日：2012-12-18

申请号：US12263947

申请日：2008-11-03

Applicant: Dimiter N Petsev ,  Erin Derbins ,  Sergio Mendez ,  Shailendra Rathod ,  Nick Carroll ,  David A. Weitz

Inventor： Dimiter N Petsev ,  Erin Derbins ,  Sergio Mendez ,  Shailendra Rathod ,  Nick Carroll ,  David A. Weitz

IPC: B32B5/16

CPC classification number: C01B33/124 ,  Y10T428/249921 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: The present disclosure provides a method for forming populations of monodisperse porous silica particles. Also provided are monodisperse populations of porous silica particles, an array of physically connected monodisperse porous silica particles and a microfluidic device for forming populations of monodisperse porous silica particles.

Abstract translation: 本公开提供了形成单分散多孔二氧化硅颗粒群的方法。 还提供了多孔二氧化硅颗粒的单分散群体，物理连接的单分散多孔二氧化硅颗粒的阵列和用于形成单分散多孔二氧化硅颗粒群的微流体装置。

公开(公告)号：US08333941B1

公开(公告)日：2012-12-18

申请号：US12581414

申请日：2009-10-19

Applicant: Plamen Atanassov ,  Elise Switzer ,  Datye Abhaya ,  Timothy Olson ,  Daniel Konopka ,  Svitlana Pylypenko ,  Timothy L Ward

Inventor： Plamen Atanassov ,  Elise Switzer ,  Datye Abhaya ,  Timothy Olson ,  Daniel Konopka ,  Svitlana Pylypenko ,  Timothy L Ward

IPC: C01G31/00

CPC classification number: C01G33/00 ,  C01G99/00 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/04

Abstract: Mesoporous conductive niobium and niobium-ruthenium particles and methods for forming the same are described. In some cases the particles are suitable for use as a fuel cell catalyst. The described aerosol-based synthesis method allows for single step formation and processing of the particles.

Abstract translation: 描述介孔导电铌和铌 - 钌颗粒及其形成方法。 在某些情况下，颗粒适合用作燃料电池催化剂。 所描述的基于气溶胶的合成方法允许颗粒的单步形成和加工。