公开(公告)号：US20110055547A1

公开(公告)日：2011-03-03

申请号：US12870403

申请日：2010-08-27

Applicant: Gen-Cher Lee ,  Der-Tsai Lee ,  Laurent Lin

Inventor： Gen-Cher Lee ,  Der-Tsai Lee ,  Laurent Lin

IPC: G06F12/14 ,  H04L9/00

CPC classification number: H04L63/102 ,  G06F21/6245 ,  H04L63/0428 ,  H04L63/18 ,  H04L2463/102

Abstract: Some general aspects relate to secured means for managing and delivering personal information, for example, in the context of electronic commerce. A request from a first entity to encrypt personal information includes a first specification of the personal information to be encrypted. An encrypted specification of the personal information is then generated according to an encoding strategy. The encrypted specification of the personal information is provided to the first entity for subsequent use by a personal information user. A second entity sends a request to decrypt the encrypting specification of the personal information. Upon determining that the second entity is an authorized personal information receiver, a decrypted specification of the personal information is formed according to a decoding strategy determined based on an analysis of the encrypted specification. This decrypted specification of the personal information is then provided to the second entity.

Abstract translation: 一些一般方面涉及用于管理和传送个人信息的安全手段，例如在电子商务的背景下。 来自第一实体的加密个人信息的请求包括要加密的个人信息的第一规范。 然后根据编码策略生成个人信息的加密规范。 将个人信息的加密规范提供给第一实体以供个人信息用户随后使用。 第二实体发送解密个人信息加密规范的请求。 在确定第二实体是授权的个人信息接收器时，根据基于加密规范的分析确定的解码策略来形成个人信息的解密规范。 然后将该解密的个人信息规范提供给第二实体。

公开(公告)号：US07892771B2

公开(公告)日：2011-02-22

申请号：US12429721

申请日：2009-04-24

Applicant: Andrew H.-J. Wang ,  Kai-Fa Huang

Inventor： Andrew H.-J. Wang ,  Kai-Fa Huang

IPC: C12N9/00 ,  C12N9/10 ,  C12N9/86 ,  C12P21/06 ,  G01N31/00 ,  G06F19/00 ,  G06G7/48

CPC classification number: C12N9/104 ,  C07K2299/00 ,  G01N2333/9108 ,  Y02A90/26

Abstract: A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat QC-associated disorders is also described.

Abstract translation: 描述了谷氨酰胺环化酶（QC）的晶体结构。 还描述了制备QC的晶体结构的方法和用于鉴定QC候选抑制剂的方法。 此外，还描述了可用于治疗QC相关疾病的合理设计或鉴定新抑制剂的结构基础。

公开(公告)号：US07888337B2

公开(公告)日：2011-02-15

申请号：US12201955

申请日：2008-08-29

Applicant: Chi-Huey Wong ,  Jim-Min Fang ,  Jiun-Jie Shie ,  Yih-Shyun Edmond Cheng ,  Jia-Tsrong Jan

Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Jiun-Jie Shie ,  Yih-Shyun Edmond Cheng ,  Jia-Tsrong Jan

IPC: A61K31/66

CPC classification number: A61K31/70 ,  A61K31/7076

Abstract: Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

Abstract translation: 描述了新的膦酸酯化合物。 该化合物具有作为抗H1N1和H5N1病毒野生型和H274Y突变体的神经氨酸酶抑制剂的活性。 本公开还提供了通过D-木糖对已知的神经氨酸酶抑制剂奥司他韦和抗流感药物Tamiflu以及新的膦酸酯化合物的对映选择性合成途径。 Tamiflu和高效神经氨酸酶抑制剂Tamiphosphor的另一种有效和灵活的合成还通过11个步骤实现，并且来自容易获得的发酵产物（1S-顺式）-3-溴-3,5-环己二烯-1的总收率> 20％ 2-二醇。 大多数反应中间体是以晶体形式获得，而不需要繁琐的纯化程序。 关键转化包括溴芳烃顺式 - 二氢二醇的初始区域和立体选择性溴酰胺化，以及最终的钯催化羰基化和膦酰化反应。

公开(公告)号：US20110015096A1

公开(公告)日：2011-01-20

申请号：US12610749

申请日：2009-11-02

Applicant: KUO PING CHIU

Inventor： KUO PING CHIU

IPC: C40B40/06 ,  C07H21/00 ,  C40B50/00

CPC classification number: C40B50/06 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/06

Abstract: Multiplex barcoded Paired-End Ditag (mbPED) library construction for ultra high throughput sequencing is disclosed. The mbPED library comprises multiple types of barcoded Paired-End Ditag (bPED) nucleic acid fragment constructs, each of which comprises a unique barcoded adaptor, a first tag, and a second tag linked to the first tag via the barcoded adaptor. The two tags are the 5′- and 3′-ends of a nucleic acid molecule from which they originate. The barcoded adaptor comprises a barcode, a first polynucleotide sequence comprising a first restriction enzyme (RE) recognition site, and a second polynucleotide sequence comprising a second RE recognition site and covalently linked to the first polynucleotide sequence via the barcode. The two REs lead to cleavage of a nucleic acid at a defined distance from their recognition sites. The length of the adaptor is set so that the bPED nucleic acid fragment fits one-step sequencing.

Abstract translation: 公开了用于超高通量测序的多路复用条形码配对结束Ditag（mbPED）库构建。 mbPED库包含多种类型的条形码配对结束分析（bPED）核酸片段构建体，每个构建体包含独特的条形码适配器，第一标签和通过条形码适配器链接到第一标签的第二标签。 两个标签是来源于其的核酸分子的5'和3'末端。 条形适配器包括条形码，包含第一限制酶（RE）识别位点的第一多核苷酸序列和包含第二RE识别位点的第二多核苷酸序列，并经由条形码共价连接到第一多核苷酸序列。 两个RE导致在与其识别位点限定距离处的核酸裂解。 适配器的长度设定为使得bPED核酸片段适合一步测序。

公开(公告)号：US20100308303A1

公开(公告)日：2010-12-09

申请号：US12478084

申请日：2009-06-04

Applicant: Yia-Chung Chang ,  David M.T. Kuo

Inventor： Yia-Chung Chang ,  David M.T. Kuo

IPC: H01L29/66 ,  H01L21/02

CPC classification number: H01L21/28273 ,  B82Y10/00 ,  B82Y30/00 ,  H01L29/122 ,  H01L29/127 ,  H01L29/42324 ,  H01L29/66977 ,  H01L29/7888 ,  Y10S438/962

Abstract: A method of making a quantum dot memory cell, the quantum dot memory cell including an array of quantum dots disposed between a first electrode and a second electrode, includes obtaining values for a tunneling current through the quantum dot memory cell as a function of a voltage applied to the quantum dot memory cell and selecting parameters of the quantum dot memory cell such that the tunneling current through the quantum dot memory cell exhibits a bistable current for at least some values of the voltage applied to the quantum dot memory cell. The values for the tunneling current are determined on the basis of a density of states of the array of quantum dots.

Abstract translation: 一种制造量子点存储单元的方法，包括设置在第一电极和第二电极之间的量子点阵列的量子点存储单元包括获得通过量子点存储单元的隧穿电流的值作为电压的函数 施加到量子点存储单元并且选择量子点存储单元的参数，使得通过量子点存储单元的隧穿电流对施加到量子点存储单元的电压的至少一些值呈现双稳态电流。 基于量子点阵列的状态密度来确定隧穿电流的值。

公开(公告)号：US07846719B2

公开(公告)日：2010-12-07

申请号：US11331704

申请日：2006-01-13

Applicant: Andrew H.-J. Wang ,  Kai-Fa Huang

Inventor： Andrew H.-J. Wang ,  Kai-Fa Huang

IPC: C12N15/00 ,  C12N1/20 ,  C12P21/04

CPC classification number: C12N9/104 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C12N15/62

Abstract: A vector for expressing a soluble glutaminyl cyclase (QC) in bacterial cells is described. The vector contains a sequence encoding a fusion QC, which has a fusion protein tag selected from a Nus protein tag or a thioredoxin (Trx) tag, a QC, and a linker having at least one (His)x-tag between the QC and the fusion protein tag, in which x is an integer of at least 6. Methods for expressing a soluble glutaminyl cyclase (QC) by the vector are also described.

Abstract translation: 描述了用于在细菌细胞中表达可溶性谷氨酰胺环化酶（QC）的载体。 载体包含编码融合QC的序列，其具有选自Nus蛋白标签或硫氧还蛋白（Trx）标签，QC和在QC和QC之间具有至少一个（His）x-标签的接头的融合蛋白标签） 融合蛋白标签，其中x为至少6的整数。还描述了通过载体表达可溶性谷氨酰胺环化酶（QC）的方法。

公开(公告)号：US20100306862A1

公开(公告)日：2010-12-02

申请号：US12785653

申请日：2010-05-24

Applicant: CHE-KUN JAMES SHEN ,  KUEN-JER TSAI

Inventor： CHE-KUN JAMES SHEN ,  KUEN-JER TSAI

IPC: G01N33/68 ,  A01K67/027 ,  C12N5/079

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N5/0618

Abstract: Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed.

Abstract translation: 公开了具有泛素阳性夹杂物（FTLD-U）的额颞叶变性的非人动物模型。 本发明涉及一种转基因小鼠，其基因组包含可操作地连接到有效增加小鼠脑中转基因表达的神经元特异性启动子的转基因，其中转基因包含编码TAR DNA结合蛋白43的核苷酸序列（ TDP-43）。 转基因小鼠表现出减少或受损的学习和记忆能力，并且可能进一步显示出逐渐受损或减少的运动功能。 还公开了使用这些动物模型的方法。

公开(公告)号：US07838005B2

公开(公告)日：2010-11-23

申请号：US12561321

申请日：2009-09-17

Applicant: Chih-Cheng Chen ,  Shyh-Jer Huang ,  Yi-Wen Lin

Inventor： Chih-Cheng Chen ,  Shyh-Jer Huang ,  Yi-Wen Lin

IPC: A61K39/00

CPC classification number: G01N33/5035 ,  A61K31/7052 ,  A61K48/00 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2800/042

Abstract: Disclosed are a method of for treating insulin resistance and a method identifying a compound for treating insulin resistance.

Abstract translation: 公开了一种治疗胰岛素抵抗的方法，以及鉴定用于治疗胰岛素抵抗的化合物的方法。

公开(公告)号：US07804605B2

公开(公告)日：2010-09-28

申请号：US12073486

申请日：2008-03-06

Applicant: Ing-Shouh Hwang ,  En-Te Hwu ,  Kuang-Yuh Huang

Inventor： Ing-Shouh Hwang ,  En-Te Hwu ,  Kuang-Yuh Huang

IPC: G01B11/14

CPC classification number: G01B11/0608 ,  G01B11/272 ,  G01B21/042

Abstract: The present invention provides an optical multi-axis linear displacement measurement system and a method thereof, and the system can detect the reflected light from the top surface of the object so as to obtain multi-axis linear displacements of the object. The optical multi-axis linear displacement measurement system utilizes a non-contact optical method for obtaining multi-axis linear displacements of the object and it can perform simultaneous multi-axis linear displacement measurements. The advantages of the system and method include: high response speed (bandwidth) for dynamic measurement, simple structure, cost effective, and high sensitivity for displacement measurements.

Abstract translation: 本发明提供一种光学多轴线性位移测量系统及其方法，该系统可以检测来自物体顶表面的反射光，从而获得物体的多轴线性位移。 光学多轴线性位移测量系统利用非接触光学方法获得物体的多轴线性位移，并可同时执行多轴线性位移测量。 该系统和方法的优点包括：动态测量的高响应速度（带宽），结构简单，成本有效，位移测量灵敏度高。

公开(公告)号：US07718378B2

公开(公告)日：2010-05-18

申请号：US11767120

申请日：2007-06-22

Applicant: Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-Iu Hung

Inventor： Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-Iu Hung

IPC: G01N33/53

CPC classification number: G01N33/564 ,  G01N2800/104 ,  G01N2800/245

Abstract: Disclosed are uses of granulysin in methods of diagnosing or treating autoimmune disorders.

Abstract translation: 公开了颗粒溶素在诊断或治疗自身免疫性疾病的方法中的用途。