公开(公告)号：US11998332B2

公开(公告)日：2024-06-04

申请号：US18381369

申请日：2023-10-18

申请人： Magnolia Medical Technologies, Inc.

发明人： Gregory J. Bullington ,  Richard G. Patton ,  Jay M. Miazga ,  Shan E. Gaw

IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B5/153

CPC分类号： A61B5/150221 ,  A61B5/1405 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150251 ,  A61B5/150946 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/15003

摘要： An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

公开(公告)号：US11998211B2

公开(公告)日：2024-06-04

申请号：US18342556

申请日：2023-06-27

申请人： AtriCure, Inc.

发明人： Matthew J. Winkler ,  Kenneth Lance Miller ,  Matthew Monti ,  Todd Frangolis ,  Nicholas Bailey ,  Robert M. Trusty

IPC分类号： A61B17/12 ,  A61B17/122

CPC分类号： A61B17/12031 ,  A61B17/12099 ,  A61B17/1227

摘要： An occlusion clip comprising: (a) a spring; (b) a first runner including a first open top and a first open end adjacent the first open top, the first runner including a first interior camming surface partially delineating a first interior cavity that is open by way of the first open top and the first open end; (c) a second runner including a second open top and a second open end adjacent the second open top, the second runner including a second interior camming surface partially delineating a second interior cavity that is open by way of the second open top and the second open end, where the spring is configured to be coupled to the first runner and the second runner, where the first interior cavity is configured to receive a first portion of the spring, where the second interior cavity is configured to receive a second portion of the spring, where the first camming surface is configured to engage a first cam of the spring, and where the second camming surface is configured to engage a second cam of the spring.

公开(公告)号：US11992459B2

公开(公告)日：2024-05-28

申请号：US15778110

申请日：2016-11-23

申请人： Ron Nagar

发明人： Ron Nagar

IPC分类号： F25D3/08 ,  A61J1/14 ,  A61J1/16 ,  A61M5/00 ,  A61M5/168 ,  A61M5/24 ,  A61M5/44 ,  A61M5/142

CPC分类号： A61J1/165 ,  A61J1/1468 ,  A61M5/002 ,  A61M5/16804 ,  A61M5/24 ,  A61M5/44 ,  F25D3/08 ,  A61J2200/42 ,  A61J2200/44 ,  A61J2200/50 ,  A61J2200/72 ,  A61M5/142 ,  A61M5/445 ,  A61M2205/13 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3561 ,  A61M2205/3606 ,  A61M2205/3633 ,  A61M2205/364 ,  A61M2205/3646 ,  A61M2205/3653 ,  A61M2205/502 ,  A61M2205/6045 ,  A61M2205/6054 ,  A61M2205/6063 ,  A61M2205/8206 ,  F25D2303/083 ,  F25D2400/36

摘要： An apparatus, comprising an environmental control element configured to control at least one environmental condition of a substance contained within a chamber, the environmental control element includes a thermal insulator configured to provide a thermal shield to the substance and a phase change material (PCM) configured to thermally regulate at least one environmental condition. The environmental control element is configured to control the environmental condition without use of an external power source, and the PCM is configured to return to its solid phase without user intervention.

公开(公告)号：USD1026866S1

公开(公告)日：2024-05-14

申请号：US29818562

申请日：2021-12-09

申请人： OXIWEAR, INC.

设计人： George Donald Beckstein, III ,  Ben Salthouse ,  Frederick Zacharias Kruger ,  Jan Boonzaaier du Preez

摘要： FIG. 1 is a front view of a first embodiment of the new design for an earpiece;
FIG. 2 is a rear view thereof;
FIG. 3 is a left side view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a top view thereof;
FIG. 6 is a bottom view thereof;
FIG. 7 is a front, upper, left perspective view thereof;
FIG. 8 is a front, upper, right perspective view thereof;
FIG. 9 is a front, lower, right perspective view thereof;
FIG. 10 is a front, lower, left perspective view thereof;
FIG. 11 is a rear, upper, right perspective view thereof;
FIG. 12 is a rear, upper, left perspective view thereof;
FIG. 13 is a rear, lower, right perspective view thereof; and,
FIG. 14 is a rear, lower, left perspective view thereof.

公开(公告)号：US11984564B1

公开(公告)日：2024-05-14

申请号：US18543515

申请日：2023-12-18

申请人： 24M Technologies, Inc.

发明人： Junzheng Chen ,  Naoki Ota ,  Chad Alan Hartzog ,  Xiaoming Liu ,  Michelle Robyn Brouwer ,  Anthony D'Angelo ,  Daniel Salazar ,  Timothy Allen Hans ,  Junhua Song

IPC分类号： H01M10/42 ,  H01M10/0562 ,  H01M10/44 ,  H01M10/48 ,  H01M50/431 ,  H01M50/449 ,  H02J7/00

CPC分类号： H01M10/4235 ,  H01M10/0562 ,  H01M10/425 ,  H01M10/44 ,  H01M10/48 ,  H01M50/431 ,  H01M50/449 ,  H02J7/0047 ,  H01M2010/4271 ,  H01M2200/00 ,  H01M2300/0068

摘要： Embodiments described herein relate to electrochemical cells with dendrite prevention mechanisms. In some aspects, an electrochemical cell can include an anode disposed on an anode current collector, a cathode disposed on a cathode current collector, the cathode having a first thickness at a proximal end of the cathode and a second thickness at a distal end of the cathode, the second thickness greater than the first thickness, a first separator disposed on the anode, a second separator disposed on the cathode, an interlayer disposed between the first separator and the second separator, the interlayer including electroactive material and having a proximal end and a distal end, and a power source electrically connected to the proximal end of the cathode and the proximal end of the interlayer, the power source configured to maintain a voltage difference between the cathode and the interlayer below a threshold value.

公开(公告)号：US11981719B2

公开(公告)日：2024-05-14

申请号：US16954902

申请日：2018-12-20

申请人： Alteogen, Inc.

发明人： Soon Jae Park ,  Jaehyeong Ko ,  Sun-Ah You ,  Sang Hoon Yun

IPC分类号： A61K38/00 ,  A61K47/62 ,  C07K14/61 ,  C07K14/81

CPC分类号： C07K14/61 ,  A61K47/62 ,  C07K14/8125 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.

公开(公告)号：US11975111B2

公开(公告)日：2024-05-07

申请号：US17193058

申请日：2021-03-05

申请人： Tiziana Life Sciences PLC

发明人： Kunwar Shailubhai

IPC分类号： A61K9/51 ,  A61K9/00 ,  A61K31/7068 ,  A61K38/12 ,  A61K45/06 ,  A61K47/24

CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K31/7068 ,  A61K38/12 ,  A61K45/06 ,  A61K47/24 ,  A61K31/7068 ,  A61K2300/00

摘要： The disclosure provides compositions comprising dactinomycin, formulated for delivery by nanoparticle, and methods for treating a myelodysplastic syndrome (MDS) or cancer, for example, NPM1-mutated acute myeloid leukemia (AML), by administration of the compositions of the disclosure.

公开(公告)号：US11974978B2

公开(公告)日：2024-05-07

申请号：US17713893

申请日：2022-04-05

申请人： Microbion Corporation

发明人： Brett Hugh James Baker

IPC分类号： A61K31/29 ,  A61K9/14 ,  A61P17/02

CPC分类号： A61K31/29 ,  A61K9/14 ,  A61P17/02

摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.

公开(公告)号：US11972420B2

公开(公告)日：2024-04-30

申请号：US17554857

申请日：2021-12-17

申请人： EYGS LLP

发明人： Duncan James Westland

IPC分类号： G06Q20/38 ,  G06F16/23 ,  G06Q20/06 ,  H04L9/06

CPC分类号： G06Q20/3827 ,  G06F16/2379 ,  G06Q20/065 ,  H04L9/0643

摘要： Some embodiments disclose the use of zero-knowledge proofs (ZKPs) to prevent or at least mitigate privacy compromises that can occur to transactions conducted on distributed ledger-based networks (DLNs). In particular, some embodiments disclose methods and systems where ZKPs can be used to keep confidential or at least mitigate public revelation of private transaction data due to the analyses of the transaction fee or gas paid to facilitate the transaction on the DLN.

公开(公告)号：US11971899B1

公开(公告)日：2024-04-30

申请号：US18452064

申请日：2023-08-18

申请人： iCIMS, Inc.

发明人： Liliya Akhtyamova ,  Eoin O'Gorman

IPC分类号： G06F16/00 ,  G06F16/25 ,  G06F16/9532 ,  G06F16/9538 ,  G06Q10/0631 ,  G06Q10/1053

CPC分类号： G06F16/256 ,  G06F16/9532 ,  G06F16/9538 ,  G06Q10/063112 ,  G06Q10/1053

摘要： In an embodiment, a plurality of ballots (1) for a plurality of candidates, (2) generated by a plurality of search engines, and (3) for a job description are received. Each ballot from the plurality of ballots is generated by a search engine from the plurality of search engines different than remaining search engines from the plurality of search engines. A mathematical representation that indicates, for each candidate from the plurality of candidates, how many other candidates from the plurality of candidates that candidate was ranked higher than in the plurality of ballots is generated. A final ballot ranking the plurality of candidates is generated using a trained statistical model and based on the mathematical representation. A candidate from the plurality of candidates for the job description is identified based on the final ballot.