公开(公告)号：US11952416B2

公开(公告)日：2024-04-09

申请号：US18467405

申请日：2023-09-14

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Yiping Han

IPC: C07K16/18

CPC classification number: C07K16/18 ,  C07K2317/24 ,  C07K2317/565

Abstract: Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.

公开(公告)号：US20240108644A1

公开(公告)日：2024-04-04

申请号：US18507851

申请日：2023-11-13

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Aleksandar OBRADOVIC ,  Casey Roy AGER ,  Andrea CALIFANO ,  Charles G. DRAKE

IPC: A61K31/7068 ,  A61K31/44 ,  A61K31/7072 ,  A61P35/00

CPC classification number: A61K31/7068 ,  A61K31/44 ,  A61K31/7072 ,  A61P35/00

Abstract: Described herein is a therapeutic method that specifically addresses tumor-infiltrated regulatory T cells (Tregs) with minimal impact on the peripheral Tregs.

公开(公告)号：US11937981B2

公开(公告)日：2024-03-26

申请号：US16474986

申请日：2017-12-27

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Kenneth Shepard ,  Tiago Costa ,  Kevin Tien ,  Chen Shi

IPC: A61B8/00 ,  A61N7/00

CPC classification number: A61B8/4488 ,  A61B8/4494 ,  A61B8/42 ,  A61N2007/0026 ,  A61N2007/0086

Abstract: An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.

公开(公告)号：US20240085690A1

公开(公告)日：2024-03-14

申请号：US18231502

申请日：2023-08-08

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Jyotirmoy MANDAL ,  Yuan YANG ,  Nanfang YU

IPC: G02B26/00 ,  C08J9/28 ,  C08K5/00 ,  C09D5/33 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/20

CPC classification number: G02B26/004 ,  C08J9/286 ,  C08K5/0041 ,  C09D5/004 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/208 ,  B32B2305/026 ,  C08J2301/12 ,  C08J2301/28 ,  C08J2325/06 ,  C08J2327/06 ,  C08J2327/14 ,  C08J2327/20 ,  C08J2383/04 ,  E06B2009/2411 ,  E06B2009/2417

Abstract: A structured material is provided that includes a substrate and a porous structured polymer layer disposed thereon. The porous structured polymer layer includes a plurality of voids, and has a high hemispherical reflectance a high a hemispherical thermal emittance. The structured material is thus particularly advantageous for cool-roof coatings, enabling surfaces coated by the material to stay cool, even under strong sunlight. The material can be produced via structuring of polymers in a mixture including a solvent and a non-solvent. Sequential evaporation of the solvent and the non-solvent provide a polymer layer with the plurality of voids.

公开(公告)号：US20240085681A1

公开(公告)日：2024-03-14

申请号：US18388947

申请日：2023-11-13

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Elizabeth M.C. HILLMAN ,  Wenxuan LIANG

IPC: G02B21/00 ,  G02B3/00 ,  G02B21/33 ,  G02B21/36

CPC classification number: G02B21/0076 ,  G02B3/0087 ,  G02B21/0048 ,  G02B21/33 ,  G02B21/361

Abstract: This application describes Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy systems that incorporate a gradient index (GRIN) lens to relay images from their distal tip to their proximal tip so that 3D images of deep tissue can be captured, without undue loss of light. A zero working distance feature can be designed into the third objective to ensure that the light that exits the second objective in the SCAPE system is not lost. Alternatively, a tapered fiber bundle may be positioned between the second objective and the third objective in the SCAPE system to ensure that the light that exits the second objective is not lost. As yet another alternative, direct detection at the intermediate image plane without using a third objective can ensure that the light that exits the second objective in the SCAPE system is not lost.

公开(公告)号：US20240083985A1

公开(公告)日：2024-03-14

申请号：US18457239

申请日：2023-08-28

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Yiping Han

IPC: C07K16/12

CPC classification number: C07K16/1203 ,  C07K2317/24 ,  C07K2317/565

Abstract: Anti-Fn amyloid-like FadA antibodies and compositions are provided and methods of treating cancers, including pancreatic and colorectal, and periodontal diseases. Methods include preventing, reducing development, or treating disease in a subject in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent which inhibits or blocks an amyloid-like FadA secreted from Fusobacterium nucleatum (Fn).

公开(公告)号：US20240075168A1

公开(公告)日：2024-03-07

申请号：US18505590

申请日：2023-11-09

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Charles S. Zuker ,  Hao Jin

IPC: A61K49/00

CPC classification number: A61K49/0004

Abstract: Disclosed herein are methods for regulating an immune response using selective activation of neurons in the caudal nucleus of the solitary tract.

公开(公告)号：US11919913B2

公开(公告)日：2024-03-05

申请号：US17320158

申请日：2021-05-13

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Nicoleta Dobri ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

IPC: C07D498/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P27/02 ,  C07D401/06 ,  C07D405/14 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D495/04

CPC classification number: C07D498/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P27/02 ,  C07D401/06 ,  C07D405/14 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D495/04

Abstract: The present invention provides a compound having the structure:






wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl;
R4 is H, OH, or halogen;
B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole,

wherein the heterobicycle is other than chloro substituted indole; and
the pyrazole, when substituted, is substituted with other than trifluoromethyl,

or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11918702B2

公开(公告)日：2024-03-05

申请号：US16495557

申请日：2018-03-26

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Hans-Willem Snoeck ,  Ya-Wen Chen

IPC: C12Q1/02 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  C12N5/071 ,  G01N33/50

CPC classification number: A61L27/3633 ,  A61L27/3834 ,  A61L27/3882 ,  A61L27/3895 ,  A61L27/52 ,  C12N5/0689 ,  C12Q1/025 ,  G01N33/5082 ,  A61L2430/22 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2503/04 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/90 ,  G01N2500/10

Abstract: Described herein are new methods for making lung bud organoids (LBOs) that have the capacity of developing into branching airways and alveolar structures that a least partially recapitulate human lung development from mammalian, preferably human, pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSC), either by culturing branched LBO in a 3D matrix or by transplanting the LBO under the kidney capsule of immune deficient mice. Branched LBOs contain pulmonary endoderm and mesoderm compatible with pulmonary mesenchyme, and undergo branching morphogenesis. Also described are LBOs harboring certain mutations that induce a fibrotic phenotype, and methods of making same. The mutated (B)LBOs can be used for screening agents that may treat pulmonary fibrosis.

公开(公告)号：US20240060199A1

公开(公告)日：2024-02-22

申请号：US18270560

申请日：2021-12-29

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Jonathan VARDNER ,  Alan WEST ,  Scott BANTA

IPC: C25C1/12

CPC classification number: C25C1/12

Abstract: A copper concentrate such as chalcopyrite is contacted with an aqueous solution includes acids and a reducing agent, such as vanadium (II) ions, chromium (II) ions, or tungstozincic acid (H6ZnW12O40). The aqueous solution reduces the copper in the copper concentrate, which can then dissolve into the solution for recovery therefrom, or precipitate out of solution as copper compounds or elemental copper for recovery in as a solid phase product. The solid phase product can then be isolated, dissolved, and further electrowinned to recover a copper product from the copper concentrate. Oxidized reducing agent can be recovered in an electrochemical device with ferrous iron reactants. Hydrometallurgical routes to convert copper concentrates to copper are potentially less expensive and less polluting than current pyrometallurgical processing and an advantageous response to environmental and economic pressures for increased copper production.