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61.发明申请CARDIOTROPHIN-1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开CARDIOTROPHIN-1组合物和治疗肿瘤的方法公开(公告)号：US20070274995A1
公开(公告)日：2007-11-29
申请号：US11537537
申请日：2006-09-29
申请人： David Botstein , Audrey Goddard , David Lawrence , Diane Pennica , Margaret Roy , William Wood
发明人： David Botstein , Audrey Goddard , David Lawrence , Diane Pennica , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N1/21 , C12N1/18 , C12N5/06 , C07K16/30 , C07K14/82
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12Q2600/136 , G01N33/57484 , G01N2333/52 , G01N2500/00
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。
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公开(公告)号：US07258983B2
公开(公告)日：2007-08-21
申请号：US10895545
申请日：2004-07-21
申请人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12Q2600/136 , G01N33/57484 , G01N2333/52 , G01N2500/00
摘要： The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
摘要翻译： 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。
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公开(公告)号：US07244816B2
公开(公告)日：2007-07-17
申请号：US09997666
申请日：2001-11-15
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/52 , C07K14/705 , C07K16/18 , C07K2319/00 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6842 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070160618A1
公开(公告)日：2007-07-12
申请号：US11535254
申请日：2006-09-26
申请人： David Botstein , Audrey Goddard , David Lawrence , Diane Pennica , Margaret Roy , William Wood
发明人： David Botstein , Audrey Goddard , David Lawrence , Diane Pennica , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12Q2600/136 , G01N33/57484 , G01N2333/52 , G01N2500/00
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
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65.发明申请Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity 审中-公开成纤维细胞生长因子-19（FGF-19）核酸和多肽以及用于治疗肥胖症的方法公开(公告)号：US20070042395A1
公开(公告)日：2007-02-22
申请号：US11339772
申请日：2006-01-25
申请人： David Botstein , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Margaret Roy
发明人： David Botstein , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Margaret Roy
CPC分类号： C12Q1/6883 , C07K14/50 , C07K2317/24 , C07K2319/00 , C12Q2600/158
摘要： The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
摘要翻译： 本发明涉及属于成纤维细胞生长因子家族的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 此外，提供了治疗肥胖症的方法。
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公开(公告)号：US20070041964A1
公开(公告)日：2007-02-22
申请号：US11488375
申请日：2006-07-17
申请人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
发明人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C07K16/40 , C07K16/42
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译： 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。
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67.发明申请Classification of patients having diffuse large B-cell lymphoma based upon gene expresson 失效基于基因表达的弥漫性大B细胞淋巴瘤患者的分类公开(公告)号：US20070026453A1
公开(公告)日：2007-02-01
申请号：US11542552
申请日：2006-10-03
申请人： Ronald Levy , Mark Wechser , Izidore Lossos , Robert Tibshirani , Ash Alizadeh , David Botstein
发明人： Ronald Levy , Mark Wechser , Izidore Lossos , Robert Tibshirani , Ash Alizadeh , David Botstein
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/16
摘要： Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression values obtained from DLBCL patients can stratify patients in the classification groups. The methods and kits can be used to predict overall patient survival.
摘要翻译： 公开了基于多个基因的表达来分类具有弥漫性大B细胞淋巴瘤（DLBCL）的患者的方法和试剂盒。 实时定量RT-PCR可用于测量表达值。 将来自患者的肿瘤样品中的多个基因的表达值与从DLBCL患者获得的参照表达值相关联可以对分类组中的患者进行分层。 方法和试剂盒可用于预测总体患者生存。
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公开(公告)号：US07157247B2
公开(公告)日：2007-01-02
申请号：US09989730
申请日：2001-11-20
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/52 , C07K14/705 , C07K16/18 , C07K2319/00 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6842 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060275864A9
公开(公告)日：2006-12-07
申请号：US10970823
申请日：2004-10-20
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060246540A1
公开(公告)日：2006-11-02
申请号：US11240891
申请日：2005-09-29
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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