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公开(公告)号：US10308716B2
公开(公告)日：2019-06-04
申请号：US15027775
申请日：2014-09-24
IPC分类号： C07K16/18 , A61K39/395 , C07K16/28 , C07K14/435 , A61K39/39 , C07K16/30 , A61K39/00
摘要： The invention relates to a method for producing polyclonal antibodies against an antigenic target protein which comprises inducing an immune response in a host by applying an immunogenic composition comprising membrane vesicles incorporating said antigenic target protein to said host and obtaining antibodies against said target protein from the host's serum. A more specific embodiment of this method comprises at least the following steps: a) synthesizing the target protein my means of an in vitro translation reaction in a reaction medium comprising a nucleic acid template coding for the target protein and a cell lysate which contains membrane vesicles; b) separating membrane vesicles comprising the synthesized target protein from the medium; c) providing the membrane vesicles comprising the synthesized target protein in a physiologically compatible medium; d) applying the membrane vesicles of step c) to a host; e) testing a serum sample of the host for a specific immune response against said target protein; and f) obtaining specific antibodies against said target protein from the serum of a host exhibiting a specific immune response against said target protein.
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62.发明申请公开(公告)号：US20190113396A1
公开(公告)日：2019-04-18
申请号：US16097255
申请日：2017-03-31
发明人： Guenter R. FUHR , Heiko ZIMMERMANN
摘要： The invention relates to a method for monitoring the temperature of a cryopreserved biological sample. The invention also relates to a device for monitoring the temperature of a cryopreserved biological sample. The device (10) for monitoring the temperature of a cryopreserved biological sample comprises a sample container (1) having a receiving space (2) for receiving a biological sample (6). The device also comprises at least one chamber (11) having an interior that is not fluidically connected to the receiving space (2) and is only partially filled with an indicator substance (7) with a melting temperature in a region of −20° C. to −140° C. The chamber (11) has a barrier (13) that causes the indicator substance (7) to move into a second sub-region (12b) of the chamber (11) when the indicator substance (7) in a first sub-region (12a) of the chamber is in the fluid aggregate state.
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公开(公告)号：US20180321219A1
公开(公告)日：2018-11-08
申请号：US15770356
申请日：2015-10-26
发明人： Heiko ZIMMERMANN , Frank STRACKE , Ronan LE HARZIC
CPC分类号： G01N21/4788 , G01N21/21 , G01N21/49 , G01N2021/479 , G01P13/00
摘要： The invention relates to a method and a device for the optical in vitro detection of a movement in a biological sample and/or for the optical in vitro detection of a movement of a component of the biological sample. The method has the following step: (a) providing an optical wide-field illumination device for illuminating the sample, said device being designed to illuminate the entire sample, and a detector (3) for detecting radiation (9; 9a, 9b) coming from the sample. The detector (3) has a detection surface (3a) which is divided into multiple detection regions (4a). The detector is additionally designed to derive (S1) detection signals (4c) of individual detection regions (4a) with respect to time, subsequently rectify (S2) the signals, preferably by generating an absolute value or squaring, and summing or averaging (S3) the derived and rectified detection signals of all of the detection regions and then providing same as an output signal (6c). The method further has the steps of illuminating the sample using the wide-field illumination device and detecting a movement in the biological sample on the basis of the output signal (6c) of the detector (3).
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公开(公告)号：US20180126634A1
公开(公告)日：2018-05-10
申请号：US15802567
申请日：2017-11-03
发明人： Laura BUERGER , Ralph KROPP , Jeroen RISSE
IPC分类号： B29C64/188 , B29C64/153 , B29C64/35 , B33Y10/00 , B33Y30/00 , B33Y40/00
CPC分类号： B29C64/188 , B22F3/1055 , B22F2003/1057 , B22F2003/1059 , B22F2003/247 , B29C64/153 , B29C64/35 , B33Y10/00 , B33Y30/00 , B33Y40/00 , Y02P10/295
摘要： Discloses are a method and apparatus for the additive manufacture of components by applying layers of powder material on a substrate or a previously produced part of a component and at least partial fusing of the powder material in the powder layer in line with the component cross-section contour along the powder layer and to an underlying solid material of the component or substrate for the purpose of building up several solid layers one on top of the other. Following fusion of the powder material the solid layer just generated is cleaned of powder material and, prior to deposition of the next solid layer, the edge of the solid layer is post-processed by softening the fusion-bonded material.
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公开(公告)号：US09878762B2
公开(公告)日：2018-01-30
申请号：US15078715
申请日：2016-03-23
IPC分类号： B65G7/02 , B63B1/00 , B63B27/10 , B65G67/20 , B63B27/16 , B63B27/36 , B66C13/02 , B66C23/20 , B66C23/52
CPC分类号： B63B27/10 , B63B27/16 , B63B27/36 , B63B2027/165 , B65G67/20 , B66C13/02 , B66C23/206 , B66C23/52
摘要： A system for launching and recovering an underwater vehicle (18), which system comprises a crane (16) and a storage location for at least one underwater vehicle (18), wherein the crane (16) is attached to the bottom of a first container (12) and the storage location is provided in a second container (14), said first container (12) being arranged on the second container (14) during an operation of launching or an operation of recovering.
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66.发明申请METHOD AND APPARATUS FOR ANALYZING A SAMPLE VOLUME COMPRISING MAGNETIC PARTICLES 审中-公开用于分析包含磁性颗粒的样品体积的方法和装置公开(公告)号：US20160178710A1
公开(公告)日：2016-06-23
申请号：US15054224
申请日：2016-02-26
发明人： Florian FIDLER
IPC分类号： G01R33/12
CPC分类号： G01R33/1223 , G01N15/0656 , G01N27/745 , G01R33/1276
摘要： The described embodiments relate to a method for analyzing a sample volume including magnetic particles. The method may include applying an electric excitation signal to a measuring coil so as to generate a magnetic field acting on the sample volume using the measuring coil. Furthermore, the method may include sensing an electric measurement signal dependent on the inductance of the measuring coil and analyzing magnetic permeability of the sample volume using the measurement signal.
摘要翻译： 所描述的实施例涉及用于分析包括磁性颗粒的样品体积的方法。 该方法可以包括将电激励信号施加到测量线圈，以便使用测量线圈产生作用在样品体积上的磁场。 此外，该方法可以包括感测取决于测量线圈的电感的电测量信号并且使用测量信号来分析样品体积的磁导率。
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67.发明申请公开(公告)号：US20160175767A1
公开(公告)日：2016-06-23
申请号：US14970199
申请日：2015-12-15
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e. V. , MUW SCREENTEC Filter- und Praezisionstechnik aus Metall GmbH
发明人： Hannes RICHTER , Susanne KAEMNITZ , Joerg GRUETZNER , Dirk MARTIN , Ingolf VOIGT
IPC分类号： B01D53/26 , H01M8/04828 , H01M8/04119 , B01D71/02 , B01D67/00
CPC分类号： B01D53/268 , B01D53/228 , B01D67/0067 , B01D69/02 , B01D71/021 , B01D71/025 , B01D2323/30 , B01D2325/20 , H01M8/04014 , H01M8/04141 , H01M8/04149 , H01M8/04156 , H01M8/04835 , Y02P70/56
摘要： The invention relates to a permselective membrane (1) for removal of water from water-containing gas mixtures, said permselective membrane (1) being a carbon membrane of a material whose structure is graphite similar and formed by at least one sequence of layers of the material, the layers being arranged in planes, adjacent layers having an average distance between the layers of less than 0.45 nm (4.5 Å), and the sequence of layers being turbostratically disordered. The invention further relates to processes for preparing membrane (1) and to uses of membrane (1) for exchanging water between two gas streams and also for removing water from chemical equilibrium reactions. Assemblies comprising membrane (1) on porous ceramic carriers (2) and apparatuses for separating water from a water-containing gas mixture are also described.
摘要翻译： 本发明涉及一种用于从含水气体混合物中去除水的选择性渗透膜（1），所述渗透选择膜（1）是一种材料的碳膜，其结构是类似石墨的材料，并通过至少一层 材料，层布置在平面中，相邻层之间的平均距离小于0.45nm（4.5），并且层序列是无序排列的。 本发明还涉及制备膜（1）的方法以及膜（1）用于在两种气流之间交换水并且还用于从化学平衡反应中除去水的方法。 还描述了在多孔陶瓷载体（2）上包括膜（1）的组件和用于从含水气体混合物中分离水的装置。
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68.发明申请TURBOMACHINE COMPONENT WITH AN EROSION AND CORROSION RESISTANT COATING SYSTEM AND METHOD FOR MANUFACTURING SUCH A COMPONENT 审中-公开具有腐蚀和耐腐蚀涂层系统的涡轮机组件及其制造方法公开(公告)号：US20140234096A1
公开(公告)日：2014-08-21
申请号：US14177766
申请日：2014-02-11
申请人： ALSTOM Technology Ltd , Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e,V. , Rolls-Royce Deutschland Ltd & Co KG
发明人： Hans-Joachim KLAM , Kai ORTNER , Bjorn ULRICHSOHN
CPC分类号： F01D5/28 , C23C14/35 , C23C28/00 , C23C28/322 , C23C28/341 , C23C28/347 , C23C28/40 , C23C28/42 , F01D5/288 , F01D9/02 , Y02T50/671
摘要： A turbomachine component of a stationary turbomachine includes a substrate made of high alloyed 10% to 18% chromium steels or titanium alloys or nickel base alloys or cobalt base alloys with a substrate surface and an erosion and corrosion resistant coating system. The coating system includes a first layer, which is deposited on the substrate surface of the turbomachine component and acts as a corrosion resistant layer and a second layer. The second layer is deposited on the first layer and acts as an erosion resistant layer, wherein the first layer is a Zr single layer and the second layer is a W/WC multilayer.
摘要翻译： 固定涡轮机的涡轮机组件包括由高合金化的10％至18％的铬钢或钛合金或镍基合金或具有基底表面和耐腐蚀和耐腐蚀涂层系统的钴基合金制成的基底。 涂覆系统包括第一层，其沉积在涡轮机组件的衬底表面上并用作耐腐蚀层和第二层。 第二层沉积在第一层上并用作抗侵蚀层，其中第一层是Zr单层，第二层是W / WC多层。
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公开(公告)号：US20240218331A1
公开(公告)日：2024-07-04
申请号：US18558226
申请日：2022-04-27
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e. V. , Universitaet des Saarlandes
发明人： Heiko ZIMMERMANN , Michael GEPP , Benjamin FISCHER
CPC分类号： C12N5/0657 , A61L27/20 , A61L27/22 , A61L27/3808 , A61L27/3826 , B33Y10/00 , B33Y80/00 , A61L2400/08 , A61L2430/20 , C12N2513/00 , C12N2533/50 , C12N2533/74
摘要： The invention relates to a method for producing vascularized biological tissue, having the steps of producing a network structure made of a plurality of interconnected filaments (11) of a support polymer, coating the network structure with a protein material, populating the coated network structure with endothelial cells (2, 2A) and tissue-forming biological cells (3), and dissolving the filaments (11) such that the vascularized tissue (1) is formed. The vascularized tissue (1) comprises cardiomyocytes, liver cells, renal cells, nerve cells, and/or pancreatic cells, for example.
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70.发明公开公开(公告)号：US20230248876A1
公开(公告)日：2023-08-10
申请号：US18015660
申请日：2021-08-05
发明人： Horst BOETTCHER , Michael HOFFMANN
IPC分类号： A61L9/18 , A41D13/11 , B01D46/00 , B01D39/14 , B01D53/00 , B01D53/81 , A61L9/014 , F24F3/16 , F24F8/24 , A62B23/02
CPC分类号： A61L9/18 , A41D13/1192 , B01D46/0028 , B01D39/14 , B01D53/007 , B01D53/81 , A61L9/014 , F24F3/16 , F24F8/24 , A62B23/025 , B01D2279/65 , B01D2279/50 , B01D2239/0442 , B01D2239/0478 , B01D2239/10 , B01D2259/802 , B01D2259/4541 , B01D2257/91 , B01D2258/06 , A61L2209/14 , A61L2209/16
摘要： A self-disinfecting antiviral filter material 10 includes an air-permeable carrier 11 and a composite coating 12 including at least one color pigment 13 with antiviral activity and an inorganic matrix material 14 bonded to the carrier 11. The at least one color pigment 13 preferably includes at least one compound from the group of phthalocyanines. The matrix material is preferably selected from the group including metal oxides. An air filter device including the self-disinfecting antiviral filter material, a method of manufacturing the filter material, and a method of inactivating viruses are also described.
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