公开(公告)号：US5618678A

公开(公告)日：1997-04-08

申请号：US340754

申请日：1994-11-16

申请人： James D. Kelly ,  Mark J. Murray

发明人： James D. Kelly ,  Mark J. Murray

IPC分类号： C12N1/19 ,  C07K14/71 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  G01N33/53 ,  C12Q1/00

CPC分类号： C07K14/71

摘要： Isolated DNA molecules that encode a novel PDGF receptor are disclosed. The receptor binds the AA, AB and BB isoforms of PDGF with high affinity. Cells transfected or transformed with the DNA molecules are also disclosed. The cells can be used within methods for detecting PDGF agonist or antagonist activity in a test compound.

摘要翻译： 公开了编码新型PDGF受体的分离的DNA分子。 该受体以高亲和力结合PDGF的AA，AB和BB同种型。 还公开了用DNA分子转染或转化的细胞。 细胞可用于在测试化合物中检测PDGF激动剂或拮抗剂活性的方法中。

公开(公告)号：US5579277A

公开(公告)日：1996-11-26

申请号：US432908

申请日：1995-05-01

申请人： James D. Kelly

发明人： James D. Kelly

IPC分类号： G11C8/12 ,  G11C13/00

CPC分类号： G11C8/12

摘要： A device and method are provided for mapping address bus bits to memory address by using interleaved and non-interleaved modes so that every desired row and column configuration stored in a register file may be supported. Also, the device and method allow a combination of interleaved and non-interleaved memory bank pairs to be used by registering row and column address in a plurality of registers corresponding to interleaved and non-interleaved combinations. In particular, the memory bank pairs which are capable of being interleaved have the interleaved operation performed automatically while the memory bank pairs which cannot be interleaved have the non-interleaved operation performed thereon. As a result, the performance of the memory is enhanced while eliminating the amount of user interface necessary.

摘要翻译： 提供了一种设备和方法，用于通过使用交错和非交织模式将地址总线位映射到存储器地址，从而可以支持存储在寄存器文件中的每个期望的行和列配置。 此外，该装置和方法允许通过在对应于交错和非交织的组合的多个寄存器中注册行和列地址来使用交织和非交织的存储体对的组合。 特别地，能够被交织的存储体对具有自动执行的交织操作，而不能被交织的存储体对具有在其上执行的非交织操作。 结果，提高了存储器的性能，同时消除了需要的用户界面的数量。

公开(公告)号：US5557755A

公开(公告)日：1996-09-17

申请号：US201461

申请日：1994-02-24

申请人： William T. Krein ,  Charles M. Flaig ,  James D. Kelly

发明人： William T. Krein ,  Charles M. Flaig ,  James D. Kelly

IPC分类号： G06F13/40 ,  G06F13/36 ,  G06F13/42

CPC分类号： G06F13/4022

摘要： In a bus system including a bus, a plurality of nodes including a primary node, and a bus access coordinator, bus utilization efficiency is improved by operating the coordinator at the same clock frequency as the primary node. The primary node is the node in the bus system which accesses the bus most frequently. By running the coordinator synchronous with the primary node, the need for synchronization events between the two components is eliminated. Since the primary node accesses the bus most frequently, eliminating synchronization events with the primary node eliminates most of the synchronization events in the bus system. Thus, synchronization events are minimized which, in turn, improves bus utilization efficiency.

摘要翻译： 在包括总线，包括主节点的多个节点和总线访问协调器的总线系统中，通过以与主节点相同的时钟频率操作协调器来提高总线利用效率。 主节点是总线系统中最频繁访问总线的节点。 通过运行与主节点同步的协调器，消除了两个组件之间的同步事件的需要。 由于主节点最频繁地访问总线，消除与主节点的同步事件消除了总线系统中的大部分同步事件。 因此，同步事件被最小化，这又提高总线利用效率。

公开(公告)号：US4801542A

公开(公告)日：1989-01-31

申请号：US705175

申请日：1985-02-25

申请人： Mark J. Murray ,  James D. Kelly

发明人： Mark J. Murray ,  James D. Kelly

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07H21/04 ,  C07K14/005 ,  C07K14/15 ,  C07K14/195 ,  C07K14/49 ,  C07K14/52 ,  C12N1/16 ,  C12N1/19 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/16 ,  C12N15/33 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  C12P19/00 ,  C12P21/00

CPC分类号： C07K14/005 ,  C07K14/49 ,  C12N15/81 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/75 ,  C12N2740/11022 ,  Y10S930/12 ,  Y10S930/221

摘要： Biologically active PDGF analogs expressed in eucaryotic cells are disclosed. The analogs are produced by yeast strains transformed with an extrachromosomal element composed of a strong transcriptional promoter directing the expression of a gene which encodes a protein having substantially the same biological activity as PDGF. Suitable genes include the v-sis gene or a derivative of the v-sis gene of simian sarcoma virus or portions thereof, or the human cDNA gene for PDGF or portions thereof. In particular, DNA sequences encoding polypeptides substantially homologous to the B chain of PDGF are preferred. A secretory signal sequence may be provided upstream of the gene, enabling secretion of the gene product from the host cell. Mitogenic activity is one of the biological activities possessed by these PDGF analogs, making them useful in promoting the growth of mammalian cells.