Abstract:
Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
Abstract:
The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
Abstract:
The lamp unit includes a first substrate, a second substrate provided over the first substrate, a light emitting device provided over the second substrate, a first conductive layer and a second conductive layer provided over the second substrate, and at least one wire electrically coupling at least one of the first conductive layer and the second conductive layer to each of the light emitting device. A protective layer is provided over the first substrate and the second substrate and surrounding the light emitting device and the at least one wire, and the upper surface of the protecting layer is located at a position above the highest point of the at least one wire.
Abstract:
Ultralong carbon nanotubes can be formed by placing a secondary chamber within a reactor chamber to restrict a flow to provide a laminar flow. Inner shells can be successively extracted from multi-walled carbon nanotubes (MWNTs) such as by applying a lateral force to an elongated tubular sidewall at a location between its two ends. The extracted shells can have varying electrical and mechanical properties that can be used to create useful materials, electrical devices, and mechanical devices.
Abstract:
A liquid crystal display (LCD) device capable of reducing the number of printed circuit boards (PCBs) and the number of signal transmitters, and thus reducing manufacturing costs, is disclosed. The LCD device includes a liquid crystal panel having a display to display an image, a plurality of data drive integrated circuits (ICs) connected between one-side portion of the liquid crystal panel and a source PCB, to drive data lines arranged on the display of the liquid crystal panel, a light source unit to provide light to the liquid crystal panel, and a unified board formed with a light source driver to drive the light source unit, and a drive circuit to drive the data drive ICs.
Abstract:
2-pyridyl substituted imidazoles of the formula (I) as shown in claim 1, are provided, which are useful in the treatment of diseases mediated by ALK5 or ALK4 inhibitors or both.
Abstract:
A high throughput screening system and method of a lactic acid-producing microorganism using a mixture of at least two pH indicators are provided. The method may be useful in determining a production amount of a lactic acid, which is a final metabolite secreted by the microorganism, more accurately, rapidly and easily.
Abstract:
A liquid crystal display device includes a liquid crystal display panel including a plurality of data lines, a plurality of gate lines, and a plurality of liquid crystal cells, the plurality of liquid crystal cells associated to a first and second liquid crystal cell groups, a data drive circuit to supply a data voltage to the data lines in response to a polarity control signal, a gate drive circuit to supply a scan pulse to the gate lines, and a polarity control circuit to generate different polarity control signals for each frame period and to control data voltage frequencies of the first and second liquid crystal cell groups to be different from each other.
Abstract:
A method to correct a phase of a data sector due to rotational slip of a disk includes measuring a difference in the phase of a servo sector between a plurality of disks and adjusting an amount of cylinder skew of a logical data sector between the plurality of disks based on the measured difference in the phase of a servo sector between the plurality of disks.
Abstract:
A data recording method including, when moving data stored in a cache to a data storage medium, selecting one cache area from an extended cache area group of the data storage medium by using managing information of a translation layer, moving the data stored in the cache to the selected cache area by using a physical address of the data storage medium on the selected cache area, and updating the managing information of the translation layer, wherein the managing information of the translation layer includes a physical block address-based address of the extended cache area group in the data storage medium.