公开(公告)号：US20050059885A1

公开(公告)日：2005-03-17

申请号：US10939953

申请日：2004-09-13

Applicant: Tony Melkent ,  Kevin Foley ,  Bradley Estes ,  Joseph Chaudoin

Inventor： Tony Melkent ,  Kevin Foley ,  Bradley Estes ,  Joseph Chaudoin

IPC: A61B19/00 ,  A61B1/00 ,  A61B17/16 ,  A61B17/17 ,  A61B17/56 ,  A61F2/28 ,  A61F2/44 ,  A61F2/46 ,  A61B5/05

CPC classification number: A61F2/4611 ,  A61B17/1757 ,  A61B34/20 ,  A61B34/25 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2034/254 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/2839 ,  A61F2002/4627 ,  A61F2002/4632 ,  Y10S606/907 ,  Y10S606/909 ,  Y10S606/912 ,  Y10S606/914

Abstract: A guide is disclosed for use in performing spinal surgery to prepare across a spinal disc and adjacent vertebrae an implantation space. The guide is associated with a computer controlled surgical navigation system employing an energy-detecting array to track positions of the guide in three dimensional space relative to a known reference point. The guide comprises a body for providing protected access to prepare across the spinal disc and into the adjacent vertebrae the implantation space. The body has a passage adapted to receive a bone removal device for forming the implantation space through the body. At least one electrically energizable energy emitter array is attached to the body for use in identifying the location of the guide relative to the adjacent vertebrae. A system and method for using the guide in spinal surgery are also disclosed.

Abstract translation: 公开了用于执行脊柱手术以在脊椎盘和相邻椎骨上准备植入空间的引导件。 该指南与使用能量检测阵列的计算机控制手术导航系统相关联，以相对于已知的参考点跟踪三维空间中的引导的位置。 引导件包括用于提供受保护的通路以准备穿过脊椎盘并进入相邻椎骨的植入空间的主体。 身体具有适于接收用于通过身体形成植入空间的骨去除装置的通道。 至少一个电激励能量发射器阵列附接到主体以用于识别引导件相对于相邻椎骨的位置。 还公开了在脊柱手术中使用该引导件的系统和方法。

公开(公告)号：US20050049623A1

公开(公告)日：2005-03-03

申请号：US10653281

申请日：2003-09-02

Applicant: Jeffrey Moore ,  James Duncan ,  Jeffrey Scifert ,  Charles Branch ,  Kevin Foley

Inventor： Jeffrey Moore ,  James Duncan ,  Jeffrey Scifert ,  Charles Branch ,  Kevin Foley

IPC: A61B17/00 ,  A61B17/16 ,  A61B17/32 ,  A61B17/34 ,  A61F2/44 ,  A61F2/46

CPC classification number: A61F2/4611 ,  A61B17/00234 ,  A61B17/1604 ,  A61B17/1631 ,  A61B17/1659 ,  A61B17/1671 ,  A61B17/3423 ,  A61B2017/320032 ,  A61F2/4455 ,  A61F2002/4622 ,  A61F2002/4623 ,  A61F2002/4624 ,  A61F2002/4627 ,  A61F2002/4635

Abstract: Methods and instruments are provided for performing spinal disc space preparation and implant insertion in minimally invasive procedures. The instruments include cutting instruments and implant insertion instruments adapted for insertion through a minimally invasive access portal to a spinal disc space. The proximal portions of the instruments are adapted to facilitate viewing through a proximal end opening of the access portal with the instruments positioned through the access portal while also enhancing the surgeon's control of the distal working end of the instruments while in the disc space.

Abstract translation: 提供方法和仪器用于在微创程序中进行脊椎椎间盘空间准备和植入物插入。 仪器包括切割仪器和植入物插入器械，适于通过微创入口进入椎间盘空间进行插入。 仪器的近端部分适于通过入口入口的近端开口进行观察，其中仪器通过进入门口定位，同时还增强外科医生在椎间盘空间期间仪器的远端工作端的控制。

公开(公告)号：US06833006B2

公开(公告)日：2004-12-21

申请号：US10155483

申请日：2002-05-23

Applicant: Kevin Foley ,  Harald Ebner ,  Mingyan Liu ,  Charles Branch ,  Lawrence M. Boyd

Inventor： Kevin Foley ,  Harald Ebner ,  Mingyan Liu ,  Charles Branch ,  Lawrence M. Boyd

IPC: A61F244

CPC classification number: A61F2/4455 ,  A61B2017/2837 ,  A61F2/28 ,  A61F2/30724 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/4465 ,  A61F2/447 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30093 ,  A61F2002/30125 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30176 ,  A61F2002/30261 ,  A61F2002/30377 ,  A61F2002/30382 ,  A61F2002/30428 ,  A61F2002/30485 ,  A61F2002/30489 ,  A61F2002/3052 ,  A61F2002/30522 ,  A61F2002/30565 ,  A61F2002/30571 ,  A61F2002/30579 ,  A61F2002/30616 ,  A61F2002/30626 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30787 ,  A61F2002/30795 ,  A61F2002/3082 ,  A61F2002/30836 ,  A61F2002/30848 ,  A61F2002/30879 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4619 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4635 ,  A61F2210/0019 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0054 ,  A61F2230/0082 ,  A61F2310/00011 ,  A61F2310/00017 ,  A61F2310/00179 ,  Y10S623/908

Abstract: Laterally expanding vertebral spacer devices are provided for repairing damaged vertebral discs. The vertebral spacer devices maintain the height of a distracted vertebral disc space while providing stability to the spine. In one form of the invention, a vertebral spacer device is provided with a first arm movably coupled to a second arm. The first and second arms are laterally expandable from a first width for insertion into the disc space to a second width after insertion into the disc space. The first and second arms also define a cavity therebetween for placement of bone growth material.

Abstract translation: 提供横向扩张的脊椎间隔装置用于修复受损的脊椎椎间盘。 脊椎间隔装置保持椎间盘空间分离的高度，同时为脊柱提供稳定性。 在本发明的一种形式中，脊椎间隔装置设置有可移动地联接到第二臂的第一臂。 第一和第二臂从用于插入盘空间中的第一宽度横向可膨胀到插入盘空间中的第二宽度。 第一和第二臂还在其间限定了用于放置骨生长材料的空腔。

公开(公告)号：USD484684S1

公开(公告)日：2004-01-06

申请号：US29160467

申请日：2002-05-10

Applicant: James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James S. O'Halloran

Designer： James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James S. O'Halloran

公开(公告)号：US06395031B1

公开(公告)日：2002-05-28

申请号：US09691307

申请日：2000-10-18

Applicant: Kevin Foley ,  Harald Ebner ,  Mingyan Liu ,  Charles Branch ,  Lawrence M. Boyd

Inventor： Kevin Foley ,  Harald Ebner ,  Mingyan Liu ,  Charles Branch ,  Lawrence M. Boyd

IPC: A61F244

CPC classification number: A61F2/4455 ,  A61B2017/2837 ,  A61F2/28 ,  A61F2/30724 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/4465 ,  A61F2/447 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30093 ,  A61F2002/30125 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30176 ,  A61F2002/30261 ,  A61F2002/30377 ,  A61F2002/30382 ,  A61F2002/30428 ,  A61F2002/30485 ,  A61F2002/30489 ,  A61F2002/3052 ,  A61F2002/30522 ,  A61F2002/30565 ,  A61F2002/30571 ,  A61F2002/30579 ,  A61F2002/30616 ,  A61F2002/30626 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30787 ,  A61F2002/30795 ,  A61F2002/3082 ,  A61F2002/30836 ,  A61F2002/30848 ,  A61F2002/30879 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4619 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4635 ,  A61F2210/0019 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0054 ,  A61F2230/0082 ,  A61F2310/00011 ,  A61F2310/00017 ,  A61F2310/00179 ,  Y10S623/908

Abstract: Laterally expanding vertebral spacer devices are provided for repairing damaged vertebral discs. The vertebral spacer devices maintain the height of a distracted vertebral disc space while providing stability to the spine. In one form of the invention, a vertebral spacer device is provided with a first arm movably coupled to a second arm. The first and second arms are laterally expandable from a first width for insertion into the disc space to a second width after insertion into the disc space. The first and second arms also define a cavity therebetween for placement of bone growth material.

公开(公告)号：US08901308B2

公开(公告)日：2014-12-02

申请号：US13550324

申请日：2012-07-16

Applicant: Weiwen Ying ,  David James ,  Shijie Zhang ,  Teresa Przewloka ,  Junghyun Chae ,  Dinesh U. Chimmanamada ,  Chi-Wan Lee ,  Elena Kostik ,  Howard P. Ng ,  Kevin Foley ,  Zhenjian Du ,  James Barsoum

Inventor： Weiwen Ying ,  David James ,  Shijie Zhang ,  Teresa Przewloka ,  Junghyun Chae ,  Dinesh U. Chimmanamada ,  Chi-Wan Lee ,  Elena Kostik ,  Howard P. Ng ,  Kevin Foley ,  Zhenjian Du ,  James Barsoum

IPC: C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D413/04 ,  C07D403/04 ,  C07D403/10 ,  C07D249/08 ,  C07D473/00 ,  C07D249/12 ,  C07D409/04 ,  C07D473/34

CPC classification number: C07D249/08 ,  A61K31/4196 ,  C07D249/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D473/00 ,  C07D473/34

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract translation: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。

公开(公告)号：US08768819B2

公开(公告)日：2014-07-01

申请号：US12271027

申请日：2008-11-14

Applicant: Howard W. Lutnick ,  Dean P. Alderucci ,  Mark Miller ,  Andrew Fishkind ,  Kevin Foley ,  Bill Rice ,  Brian L. Gay ,  Philip Marber ,  Charles Plott

Inventor： Howard W. Lutnick ,  Dean P. Alderucci ,  Mark Miller ,  Andrew Fishkind ,  Kevin Foley ,  Bill Rice ,  Brian L. Gay ,  Philip Marber ,  Charles Plott

IPC: G06Q40/00 ,  G06Q40/04 ,  G06Q40/06

CPC classification number: G06Q40/04 ,  G06Q40/00

Abstract: Systems and methods for administering trade orders are described. An embodiment comprises receiving, from a first server operated by a first trader, a communication including a first trade order and one or more selection criteria, the first trade order including at least one of a specified instrument, a specified quantity, and a specified price; determining that a database of trade orders does not contain a trade order matching the first trade order; identifying a plurality of traders satisfying the selection criteria; sending, to a plurality of second servers, a query including at least one of the specified instrument, the specified quantity, and the specified price; receiving, from a one of the plurality of second servers operated on behalf of a second trader, a positive response to the query; and facilitating execution of a trade between the first trader and the second trader for the specified instrument at the specified price.

Abstract translation: 描述了管理交易订单的系统和方法。 一个实施例包括从第一交易者操作的第一服务器接收包括第一交易订单和一个或多个选择标准的通信，所述第一交易订单包括指定工具，指定数量和指定价格中的至少一个 ; 确定贸易订单的数据库不包含与第一交易订单相匹配的交易订单; 识别满足选择标准的多个交易者; 向多个第二服务器发送包括所指定的仪器，指定数量和指定价格中的至少一个的查询; 从代表第二交易者操作的多个第二服务器中的一个接收对查询的肯定响应; 并以指定的价格促进第一交易者和第二交易者之间针对指定的工具的交易。

公开(公告)号：US08515857B2

公开(公告)日：2013-08-20

申请号：US13330018

申请日：2011-12-19

Applicant: Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

Inventor： Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

IPC: G06Q40/00

CPC classification number: G06Q40/04 ,  G06Q40/00 ,  G06Q40/06

Abstract: An electronic trading marketplace (ETM) communicates with interfacing modules interfacing directly with order management systems (OMS's) at trading institutions. The interfacing modules automatically transmit orders from the OMS databases to the ETM and update the OMS databases in response to orders executed at the ETM. Traders can communicate with the ETM to anonymously negotiate trades of securities.

Abstract translation: 电子交易市场（ETM）与交易机构直接与订单管理系统（OMS）接口的接口模块进行通信。 接口模块自动将订单从OMS数据库发送到ETM，并根据在ETM执行的订单更新OMS数据库。 交易者可以与ETM通信以匿名协商证券交易。

公开(公告)号：US08321323B2

公开(公告)日：2012-11-27

申请号：US12257499

申请日：2008-10-24

Applicant: Howard W. Lutnick ,  Dean P. Alderucci ,  Andrew Fishkind ,  Brian L. Gay ,  Kevin Foley ,  Mark Miller ,  Charles Plott

Inventor： Howard W. Lutnick ,  Dean P. Alderucci ,  Andrew Fishkind ,  Brian L. Gay ,  Kevin Foley ,  Mark Miller ,  Charles Plott

IPC: G06Q40/00 ,  G06Q30/00

CPC classification number: G06Q30/0633 ,  G06Q10/00 ,  G06Q10/087 ,  G06Q30/00 ,  G06Q40/04 ,  G06Q99/00

Abstract: A trading platform and trading method that allows access to additional pools of liquidity is described. Other embodiments are also described.

Abstract translation: 描述了允许访问额外的流动性池的交易平台和交易方法。 还描述了其它实施例。

公开(公告)号：US08318790B2

公开(公告)日：2012-11-27

申请号：US11807201

申请日：2007-05-25

Applicant: Weiwen Ying ,  David James ,  Shijie Zhang ,  Junghyun Chae ,  Teresa Przewloka ,  Howard P. Ng ,  Hao Li ,  Zachary Demko ,  Dinesh U. Chimmanamada ,  Chi-wan Lee ,  Zhenjian Du ,  Kevin Foley ,  Minghu Song ,  Lijun Sun ,  Keizo Koya ,  Dan Zhou ,  Shuzhen Qin

Inventor： Weiwen Ying ,  David James ,  Shijie Zhang ,  Junghyun Chae ,  Teresa Przewloka ,  Howard P. Ng ,  Hao Li ,  Zachary Demko ,  Dinesh U. Chimmanamada ,  Chi-wan Lee ,  Zhenjian Du ,  Kevin Foley ,  Minghu Song ,  Lijun Sun ,  Keizo Koya ,  Dan Zhou ,  Shuzhen Qin

IPC: A61K31/4196 ,  A61P35/00 ,  C07D249/12

CPC classification number: C07D417/04 ,  C07D249/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.