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    Synthetic methods for preparing procyanidin oligomers
    64.
    发明授权
    Synthetic methods for preparing procyanidin oligomers 失效
    原花青素低聚物的合成方法

    公开(公告)号：US06864377B2

    公开(公告)日：2005-03-08

    申请号：US10212973

    申请日：2002-08-06

    申请人： Leo J Romanczyk, Jr. ,  Amit Basak ,  Craig A Townsend

    发明人： Leo J Romanczyk, Jr. ,  Amit Basak ,  Craig A Townsend

    IPC分类号： C07D311/32 ,  C07D311/04 ,  C07D311/74 ,  C07D311/76 ,  C07D313/00

    CPC分类号： C07D311/32 ,  Y02P20/55

    摘要： Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4→8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8→8), (8→6), and (6→6) dimers and doubly branched oligomers. Crystalline 8-bromo tetra-O-benzyl (−)-epicatechin is produced under certain conditions.

    摘要翻译： 公开了用于生产具有“n”原花青素单体单元（其中n为2至18）的直链和支链原花青素低聚物的方法。该方法包括将保护的活化单体与未保护的单体偶联以产生部分保护的（4-> 8）二聚体 。 将二聚体任选地封闭，与活化的受保护的单体偶联以产生部分保护的，任选被封闭的三聚体并脱保护。 可以重复这些步骤以产生更高级的低聚物。 还提供了制备（8-> 8），（8-> 6）和（6-> 6）二聚体和双支链低聚物的方法。 在某些条件下制备8-溴四-O-苄基（ - ） - 表儿茶素的结晶。

    Foods containing a cocoa polyphenol additive
    65.
    发明授权
    Foods containing a cocoa polyphenol additive 失效
    含有可可多酚添加剂的食物

    公开(公告)号：US06777005B1

    公开(公告)日：2004-08-17

    申请号：US09717445

    申请日：2000-11-21

    申请人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    发明人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    IPC分类号： A61K3578

    CPC分类号： A61K36/185 ,  A23L33/105 ,  A61K31/353 ,  A61K31/78

    摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.

    摘要翻译： 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。