Abstract:
A tissue excision device comprises a handle. In addition, the tissue excision device comprises an elongate tissue capture member extending from the handle. The tissue capture member has a longitudinal axis and comprises a free end distal the handle. Further, the free end of the tissue capture member includes a tip, a tissue capture recess, and at least one slot extending through the free end in the tissue capture recess. Still further, the tissue excision device comprises an elongate tubular cutting member coupled to the handle. The cutting member slidingly and coaxially receives the tissue capture member. In addition, the cutting member has a free end distal the handle that includes a cutting.
Abstract:
The present invention relates to anaerobically curable compositions, methods of preparation and methods of use that provide enhanced physical properties when cured in contact with untreated inactive surfaces. The compositions which include isobornyl acrylate, isobornyl methacrylate or combinations thereof in combination with a multi(meth)acrylate and a free-radical initiator, may be used without the addition of a transition metal catalyst.
Abstract:
A device for retrieving an excised tissue segment. In an embodiment, the device comprises an elongate body having a central axis and an outer surface. In addition, the device comprises at least two prongs extending from the body in a direction substantially parallel to the central axis. Each prong includes a fixed-end coupled to the body, a free-end distal the body, an inner surface, and an outer surface substantially contiguous with the outer surface of the body. Further, the device comprises a space extending between the inner surfaces of the prongs that accommodates excised tissue.
Abstract:
Disclosed are methods and structures for fabrication of reliable and efficient memory cells. The methods involve formation of a conformal diffusion barrier layer in a via, deposition of an electrode material in the via, removal of a certain portion of the electrode material from the via to expose a the portion of the diffusion barrier layer, converting the exposed portion of the diffusion barrier layer into an oxide, forming a memory element film, and forming and patterning a top electrode. Improved electrical conduction and data retention from the memory element of a memory cell by preventing short circuits and leakage of current through the conductive diffusion barrier layer, and thereby enhanced reliability and performance of a memory cell are obtained.
Abstract:
Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the method comprises hybridizing a nucleic acid target, comprising a target nucleic acid sequence, to a nucleic acid probe, comprising a probe nucleic acid sequence, wherein the target comprises a binding ligand. The hydridized target is contacted with a receptor comprising multiple sites capable of binding the binding ligand to complex the receptor to the binding ligand, and the receptor is contacted with an amplification reagent, comprising a plurality of the binding ligands, to complex the amplification reagent to the receptor. The presence of the complexed amplification reagent then is detected, for example, by detecting the presence of a detectable label, such as a fluorescent label, for example, on the receptor or the amplification reagent. Optionally, the amplification reagent, comprising a plurality of the binding ligands, is contacted with labeled receptor molecules thereby to complex a plurality of labeled receptor molecules to the amplification reagent, and the labeled receptor molecules complexed to the amplification reagent are detected. This permits the detectable signal to be enhanced and amplified. In one embodiment, the binding ligand is biotin, the receptor is streptavidin, and the amplification reagent is an antibody or a DNA matrix. In another embodiment, an array of different nucleic acid probes immobilized on a surface, each having a defined sequence and location on the surface, may be used in the assays, thus permitting screening and detection of binding of a large number of nucleic acids.
Abstract:
A bone anchor device for attaching connective tissue to bone comprises an anchor body, a plurality of suture retaining apertures disposed in the anchor body, and deployable structure for securing the anchor body in bone. A longitudinal axis is disposed along a center of the anchor body, wherein the plurality of suture retaining apertures are spaced axially relative to one another. Additionally, in preferred embodiments, at least two of the plurality of suture retaining apertures are transversely offset from one another relative to the longitudinal axis, in staggered relation. Preferably, the deployable structure comprises a pair of deployable flaps. The anchor body comprises a substantially planar surface in which the plurality of suture retaining apertures are disposed. In its presently preferred embodiment, the anchor body comprises opposing substantially flat surfaces, wherein the plurality of suture retaining apertures extend through the entire anchor body. A stem extends proximally from a proximal end of the anchor body. At least a portion of a longitudinal slit is disposed in the stem.
Abstract:
A device for performing minimally invasive closed chest heart massage comprises a support having a plurality of curved, deployable struts, optionally carrying a sheet or inflatable bladder for engaging the pericardium. The struts are delivered to the space between the pericardium and the posterior rib cage in a radially collapsed configuration and deployed radially outwardly with minimum advancement in the axial direction.
Abstract:
A genetic sample is analyzed by providing a gene probe array including a plurality of genetic probes having different receptors. The sample is processed to include at least one fluorescently tagged ligand. The array is hybridized by exposing the probes to the processed sample such that ligands can bind to complementary receptors. Composite data having a data dynamic range is obtained from the array using an optical scanner which has a scanner dynamic range that is smaller than the data dynamic range. The scanner optically irradiates and scans the probes and detects fluorescent emissions at a first wavelength which is selected such that the scanner produces valid first data in a low intensity portion of the data dynamic range and is in saturation in at least part of a high intensity portion of the data dynamic range. The scanner then optically irradiates and scans the probes with light and detects fluorescent emissions at a second wavelength which is selected such that the scanner produces valid second data in a high intensity portion of the data dynamic range and is in cutoff in at least part of a low intensity portion of the data dynamic range. A scale factor correlation function is calculated between the first data and the second data, and is applied to convert the second data to have a same scale factor as the first data. The first data for the first portion of the data dynamic range is combined with the converted second data for the second portion of the data dynamic range to obtain the composite data.
Abstract:
A system and method for processing performance data in a telecommunication system. The system includes a site controller which is part of an element management layer of a network management hierarchy. Briefly stated, the site controller receives performance data from a network element. The performance data is associated with a plurality of ports of the network element. The network element is part of a network element layer of the network management hierarchy. The site controller selects a first port of the network element to process. The site controller determines whether the first port is cross-connected to a second port of the network element. If the first port is cross-connected to the second port, then the site controller combines performance data associated with the first port and performance data associated with the second port into a performance report. The site controller forwards the performance report to a monitoring module. The monitoring module is part of a network management layer and/or a service management layer of the network management hierarchy.
Abstract:
Described herein are a system and method of determining a far-end format of a customer service unit (CSU) operating using an Extended SuperFrame (ESF) framing format. The CSU is in communication with a network element over a DS 1 circuit. The system operates by determining whether any performance data was received from the CSU during a preceding time interval. If no performance data was received from the CSU during the preceding time interval, then the system determines whether the network element is currently configured to operate according to ANSI standard T1.403 or AT&T Recommendation 54016. If the network element is currently configured to operate according to AT&T Recommendation 54016, then the system commands the network element to operate according to ANSI standard T1.403. The system then waits a predetermined time period for receipt of valid performance data conforming to ANSI standard T1.403 from the CSU. If valid performance data conforming to ANSI standard T1.403 is received from the CSU during the predetermined time period, then the system commands the network element to operate according to ANSI standard T1.403 until further notice. If valid performance data conforming to ANSI standard T1.403 is not received from the CSU during the predetermined time period, then the system commands the network element to return to operating according to AT&T Recommendation 54016.