公开(公告)号：US20220371020A1

公开(公告)日：2022-11-24

申请号：US17660763

申请日：2022-04-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Avinash Addihalli Narayana ,  Tobias Huber

IPC: B01L9/06

Abstract: The present disclosure relates to a laboratory sample container carrier handling apparatus comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path P, and wherein the circular path P has at least one ascending ramp. The present disclosure relates further to a laboratory sample distribution system comprising such a laboratory sample container carrier handling apparatus.

公开(公告)号：US20220355303A1

公开(公告)日：2022-11-10

申请号：US17660299

申请日：2022-04-22

Applicant: Roche Diagnostics Operations, Inc

Inventor： Angelos Chotzidis ,  Stefan Soentges ,  Hans van Mierlo

IPC: B01L9/06 ,  G01N35/00 ,  B01L9/00

Abstract: A preanalytic system is disclosed. The preanalytic system comprises a cap gripper configured to grip a cap of a laboratory sample container, wherein the cap is connected to a rod of a swab located within the laboratory sample container, wherein the cap gripper is further configured to release the cap from the laboratory sample container, and a cutting device configured to cut the rod of the swab when the cap is in a position released from the laboratory sample container.

公开(公告)号：US20220317119A1

公开(公告)日：2022-10-06

申请号：US17838568

申请日：2022-06-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Toralf ZARNT ,  Dieter HEINDL ,  Alfons NICHTL ,  Frank SICHERL-BIRK

IPC: G01N33/543

Abstract: Disclosed is a method for measurement of an analyte in a microparticle-based analyte-specific binding assay, wherein the microparticles are coated with the first partner of a binding pair, the method involving mixing the coated microparticles, an analyte-specific binding agent conjugated to the second partner of the binding pair, and a sample suspected of containing or containing the analyte, wherein the second partner of the binding pair is bound to the analyte-specific binding agent via a linker having from 12 to 30 ethylene glycol units (PEG 12 to 30), thereby binding the analyte via the conjugated analyte-specific binding agent to the coated microparticles, separating the microparticles having the analyte bound via the binding pair and the analyte-specific binding agent from the mixture and measuring the analyte bound to the microparticles.

公开(公告)号：US11454634B2

公开(公告)日：2022-09-27

申请号：US15911699

申请日：2018-03-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Roberto Latini ,  Serge Masson ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68 ,  A61B5/055 ,  A61B8/08

Abstract: The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac Troponin and/or Fibroblast Growth Factor 23 (FGF-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). The present invention also relates to a system for performing an assessment whether a subject shall be subjected to an imaging based diagnostic assessment and to reagents and kits used in performing the methods disclosed herein. Moreover, the present invention is directed to a method for predicting the risk of mortality and/or of a cardiovascular event. Also encompassed is a method for diagnosing an early stage of LVH in a subject having a preserved left ventricular ejection.

公开(公告)号：US20220293404A1

公开(公告)日：2022-09-15

申请号：US17805133

申请日：2022-06-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Geistanger ,  Daniel Intelmann ,  Shirin Shahriari ,  Anton Hilger

IPC: H01J49/00

Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

公开(公告)号：US20220280938A1

公开(公告)日：2022-09-08

申请号：US17804013

申请日：2022-05-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

IPC: B01L3/00 ,  G01N30/74

Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

公开(公告)号：US20220276275A1

公开(公告)日：2022-09-01

申请号：US17675260

申请日：2022-02-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Josep Fernandez ,  Emanuel Hurni ,  Nan Li ,  Jacobo Morales Rojo Del Rio

IPC: G01N35/00

Abstract: A system and method for presenting laboratory data to a user are presented. The system comprises a perception component for continuously gathering in-situ context data regarding a laboratory and the user, a user modeling component for receiving the in-situ context data from the perception component to create a user specific model for each user, a laboratory device awareness component for monitoring the status, performance, alarms, and/or maintenance of the laboratory devices, a notification component for receiving the in-situ context data from the perception component and the laboratory device status data from the laboratory device awareness component and for processing and determining which data from the in-situ context data and the laboratory device status data are to be presented to the user, and a presentation component for presenting the processed data from the notification component. The presented data comprises both public and private notification of the data to the user.

公开(公告)号：US11408489B2

公开(公告)日：2022-08-09

申请号：US16597896

申请日：2019-10-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Walter Berberich ,  Timo Ziegler ,  Benjamin Zoelch

IPC: F16H7/02 ,  F16H55/17 ,  F16H59/68

Abstract: A drive system for driving a belt is presented. The system comprises a frame, a driving shaft connected to a motor, a controller, a driven shaft, two pulleys connected to the driven and driving shafts, and a belt. The frame supports the driving and driven shafts to mount the belt on the pulleys. A signal element is mounted on and drives with the belt. At least two detection elements are mounted on the frame so that when the signal element passes the detection elements, a signal is generated as the belt moves. The detector elements are connected to a controller which controls the motor so that when the system starts, the belt moves until the signal element generates a signal in a first detector element to fix a zero point of the belt movement. The signal of the second detector element checks the zero point during normal drive operation.

公开(公告)号：US11406979B2

公开(公告)日：2022-08-09

申请号：US16599673

申请日：2019-10-11

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

公开(公告)号：US20220235139A1

公开(公告)日：2022-07-28

申请号：US17704706

申请日：2022-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： David CASAGOLDA VALLRIBERA ,  Michael GERG ,  Michael SCHRAEML

IPC: C07K16/28 ,  G01N33/574

Abstract: The present invention relates to a monoclonal antibody, or fragment thereof, which binds to CSF-1R (Colony stimulating factor 1 receptor), in particular to human CSF-1R. The present invention further relates to the in vitro use of the monoclonal antibody, or fragment thereof, of the present invention for the detection of CSF-1R in a sample. Further encompassed by the present invention is a complex comprising the monoclonal antibody, or fragment thereof, of the present invention and CSF-1R such as the human CSF-1R polypeptide.