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公开(公告)号:US20220398722A1
公开(公告)日:2022-12-15
申请号:US17662659
申请日:2022-05-10
Inventor: Syu-Jyun PENG , Chien-Chen CHOU , Yen-Cheng SHIH , Hsu-Huai CHIU
Abstract: The present disclosure provides an operating method of a brain imaging neurological abnormality prediction system, which includes steps as follows. The T1-weighted image and the diffusion-weighted image of the patient are acquired; the image process is performed on the T1-weighted image and the diffusion-weighted image to obtain a smoothed brain standard space infarction image; the smoothed brain standard space infarction image is multiplied by and a weighted image for a post-processing to obtain a post-weight image; the post-weight image is inputted to the deep learning cross validation classification model of transfer learning to predict whether the neurological abnormality occurs within a predetermined period after the patient's brain disease.
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公开(公告)号:US11427935B2
公开(公告)日:2022-08-30
申请号:US17200321
申请日:2021-03-12
Applicant: TAIPEI MEDICAL UNIVERSITY
Inventor: How Tseng
Abstract: A passive intermittent rotating assembly can automatically adjust a part of a cleaning material when the cleaning material cleans a spinning jet each time and that can stably operate in a high-voltage environment. The passive intermittent rotating assembly includes a plurality of first abutment members and second abutment members being arranged respectively at an inner side and outer side of the main wheel along the circumferential direction, and being separated from each other to form gaps for a push portion of a push member to pass through. Each of the first abutment members includes a first inner-side abutment portion and a first outer-side abutment portion provided for abutting against the push portion. Each of the second abutment members includes a second inner-side abutment portion and a second outer-side abutment portion provided for abutting against the push portion.
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公开(公告)号:US11365200B2
公开(公告)日:2022-06-21
申请号:US16496376
申请日:2018-03-22
Applicant: TAIPEI MEDICAL UNIVERSITY , NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE, MINISTRY OF HEALTH AND WELFARE , ACADEMIA SINICA , BUDDHIST TZU CHI MEDICAL FOUNDATION
Inventor: Heng Lin , Ming-jaw Don , Ching-feng Cheng , Jing-jy Cheng , Wen-shan Li , Hui-chen Ku , Hsiao-fen Li , Hsi-hsien Chen , W J Huang
IPC: C07D493/04 , C07D495/04 , A61K31/366 , A61K31/381 , A61P3/10 , A61P3/04 , C07D491/153 , A23L33/10 , C07D491/052 , C07D495/14
Abstract: The invention relates to compounds for treating and/or preventing obesity and obesity-related disorders. Particularly, the invention provides chromanone derivatives used as ATF3 inducer and for treating and/or preventing obesity and obesity-related disorders such as heart disease, hypertension, hyperlipidemia and diabetes.
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64.
公开(公告)号:US11246499B2
公开(公告)日:2022-02-15
申请号:US16681152
申请日:2019-11-12
Inventor: San-Liang Lee , Chao-Hsiung Tseng , Ling-Hsiu Hung , Yung-Ho Hsu , Cheng-Hsien Chen
Abstract: A far-infrared emitters with physiological signal detection and method of operating the same is disclosed. A far-infrared beam module is switched on and generates far-infrared beam irradiating to a human body when a control unit starting up a microwave detecting module detecting physiological signal of the human body. The control unit is switched off when the time that the far-infrared beam irradiating on the human body reach a presetting period of time, thereby achieving the purpose of energy conservation.
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公开(公告)号:US20210213285A1
公开(公告)日:2021-07-15
申请号:US17127433
申请日:2020-12-18
Applicant: Taipei Medical University , National Cheng Kung University
Inventor: Shih-Ching CHEN , Chih-Wei PENG , Che-Wei LIN , Jia-Jin CHEN , Chun-Wei WU , Samuel WANG , Chun-Ie WU , Nguyen Van TRUONG
Abstract: A head cap with channel identification includes a head cap, channel identification module, a controlling module, and electrical stimulation modules. The head cap includes the channels therein, and the head cap includes brain regions corresponding to the brain areas of the human being. The electrical stimulation modules disposed in the channels, and the channel identification modules disposed around the peripheral of the channels. The controlling module is electrically coupled to the channel identification modules. When the electrical stimulation modules disposed in some of the channels, the channel identification modules around the peripheral of the channels and the electrical stimulation module are constituted a circuit conduction status or a short circuit status, then the channel identification module transmits a signal to the controlling module to determine the desired sites of the electrical stimulation module where is corresponding to one of the brain areas of the human being according to the signal.
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66.
公开(公告)号:US11042983B1
公开(公告)日:2021-06-22
申请号:US16884070
申请日:2020-05-27
Inventor: Jang-Zern Tsai , Syu-Jyun Peng , Yu-Wei Chen , Meng-Zong Tsai , Kuo-Wei Wang , Yeh-Lin Kuo
Abstract: The present disclosure provides an operating method of an automatic brain infarction detection system on magnetic resonance imaging (MRI), which includes steps as follows. Images corresponding to different slices of a brain of a subject are received from the MRI machine. The image mask process is performed on first and second images of the images. It is determined whether the cerebellum image intensity and the brain image intensity in the first image are matched. When the cerebellum image intensity and the brain image intensity are not matched, the cerebellar image intensity in the first image is adjusted. The first image is processed through a nonlinear regression to obtain a third image. A neural network identify an infarct region by using the first, second and third images that are cut.
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公开(公告)号:US10766951B2
公开(公告)日:2020-09-08
申请号:US15563614
申请日:2016-04-01
Applicant: TAIPEI MEDICAL UNIVERSITY
Inventor: Sy-Jye Leu , Yi-Yuan Yang , Yu-Ching Lee , Ching-Hua Su , Ko-Jiunn Liu , Hsiu-Jung Lo , Yun-Liang Yang
IPC: A61K39/00 , C07K16/14 , C12N9/88 , G01N33/569 , C12N9/60 , C07K16/18 , G01N33/573 , A61K39/395 , C07K16/02 , A61P31/10 , A61K45/06 , C07K16/40
Abstract: Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida spp., preferably Candida albicans, Candida tropicalis, fluconazole resistance Candida spp., Streptococcus, Staphylococcus.
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公开(公告)号:US20200248129A1
公开(公告)日:2020-08-06
申请号:US16439685
申请日:2019-06-12
Applicant: National Tsing Hua University , Taipei Medical University
Inventor: Fan-Gang Tseng , Li-Chern Pan , Jen-Kuei Wu , Yung-Chin Tzeng , Suei-Shen Wang
Abstract: A sperm sorter and a sperm sorting method are provided. The sperm sorter includes an inlet chamber, a swim up sorting chamber, a divergent channel, a recycling chamber and an outlet chamber. The swim up sorting chamber is communicated with the inlet chamber. The swim up sorting chamber is communicated between the inlet chamber and the divergent channel. The divergent channel has an entrance terminal close to the swim up sorting chamber and an exit terminal away from the swim up sorting chamber. A width and a depth of the entrance terminal are respectively less than a width and a depth of the exit terminal. The recycling chamber is communicated with the exit terminal of the divergent channel. The outlet chamber is communicated with a portion of the divergent channel between the entrance terminal and the exit terminal.
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公开(公告)号:US10661003B2
公开(公告)日:2020-05-26
申请号:US15872812
申请日:2018-01-16
Applicant: TAIPEI MEDICAL UNIVERSITY
Inventor: Yu-Chuan Liu
Abstract: The invention provides an apparatus of treating water to obtain small water cluster, which comprises one or more illumination devices and one or more holders holding metal particles. The invention also provides a method of preparing the small water cluster and the small water cluster prepared from the apparatus or the method.
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公开(公告)号:US10577328B2
公开(公告)日:2020-03-03
申请号:US15746964
申请日:2015-07-23
Applicant: TAIPEI MEDICAL UNIVERSITY
Inventor: Yun Yen , Jing-ping Liou , Shiow-lin Pan
IPC: C07D213/75 , C07D213/74 , A61P37/00 , A61P25/28 , A61P35/02 , A61P3/10 , C07D209/04 , C07D215/40 , C07D215/42 , C07D231/38 , C07D235/30 , C07D239/42 , C07D241/04 , C07D241/20 , C07D277/42 , C07D471/04 , C07D487/04 , A61K31/337 , A61K31/475 , A61K31/506 , A61K31/593 , A61K31/704 , A61K33/24
Abstract: The invention relates to a compound of formula (I) with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, multiple myeloma, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.
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