摘要:
The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
摘要:
The present invention pertains to a method for detecting quinolone-resistant Escherichia coli strains in a biological sample. The present invention also relates to a kit adapted to perform the inventive method.
摘要:
The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.
摘要:
Storage-stable heat-curable mixtures are described which contain(A) a polyimide which contains in the molecule at least two radicals of formula I ##STR1## wherein D is a divalent radical with a C.dbd.C double bond, (B) an alkenylphenol,(C) an epoxide group-free adduct of an epoxy resin with excess alkenylphenol or(D) a polyimide which is soluble in organic solvents or a mixture of (C) and (D).These mixtures are employed for example as laminating resins or electro-resins, as adhesives or adhesive films for application at high temperatures, or for the preparation of coatings.
摘要:
A .DELTA..sup.1,4,17 -BNC compound having the formula: ##STR1## wherein X is a substituent selected from the group consisting of OH and OCH.sub.3 ; as well as its process of production by microbiological side-chain splitting of a 17-C-side-chain steroid with a defect mutant microorganism which gives a steroid with a 17-C-.alpha.-propionic acid substituent in the absence of inhibitors inhibiting either the cleavage of the steroid ring or microorganism growth, where the defect mutant microorganisms are grown under a reduced air supply whereby an enrichment of .DELTA..sup.1,4,17 -BNC occurs.
摘要:
The mixture contains as reinforcing agent needle-shaped crystals insoluble in epoxide resin, the crystals being for example of aluminium oxide or hydroxide and acetic acid, propionic acid, benzoic acid, adipic acid or sebacic acid. These crystals improve specific mechanical properties of the elastomeric polymers obtained by curing the epoxide resin/curing agent mixture, without the elastomeric properties being lost.
摘要:
The present invention concerns a process for the softening of furs while at the same time taking the greatest possible care of the appearance of the hair. The process of this invention comprises contacting a fur with an acid aqueous liquor containing an acid protease from a fungus strain of the genus Rhizopus rhizopodiformis, said acid protease being effective in the pH range of from about 2.5 to 6.5.
摘要:
Mixtures of approximately equivalent amounts of (a) a glycidylated hydantoin and (b) a mononuclear phenol with 2 or 3 phenolic hydroxyl groups, at least one of the components (a) or (b) being trifunctional. They additionally contain a curing accelerator and on heating form mechanically good and flexible plastics which are stable to hydrolysis and can be used as building materials and foams, for the finishing and coating of textile material and for the preparation of water-permeable membranes.
摘要:
The invention relates to the manufacture of crystalline epoxide resins which exhibit a marked crystallite melt temperature. The formation of the crystallites is caused by molecule blocks which are derived from polyester-polycarboxylic acids, which contain aliphatic radicals in the chain. According to the invention, two aliphatic polyester-polycarboxylic acids (A and B) are reacted under very specific quantitative conditions with epoxide compounds which contain at least 2 epoxide groups and optionally with curing agents. The polyester-polycarboxylic acids A are purely n-aliphatic in character, whereas the polyester-polycarboxylic acids B are not. They contain radicals which are derived from dimerized mono- unsaturated or di- unsaturated fatty acids during the ester formation. These crystalline synthetic resins are particularly suitable for use as material for absorbing solar energy in solar energy collectors.
摘要:
The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.