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公开(公告)号：US20100069606A1
公开(公告)日：2010-03-18
申请号：US12283908
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C07K2/00 , C07K16/00 , C07H1/00 , C07H21/04 , C07D323/00 , C07C69/00 , C07C229/00 , C07C49/00 , C07C47/00 , C07C43/00 , C07K14/42
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号：US20100104834A1
公开(公告)日：2010-04-29
申请号：US12378086
申请日：2009-02-09
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
IPC分类号： B32B7/00
CPC分类号： C08J9/40 , Y10T428/24802 , Y10T428/24917
摘要： Articles having porous or foam-like elements are provided. The design, fabrication and structures of the articles exploit properties of reactive composite materials (RCM) and their reaction products. In particular, fluids generated by reacting RCM are utilized to create or fill voids in the porous or foam-like elements.
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公开(公告)号：US20130173293A1
公开(公告)日：2013-07-04
申请号：US13374519
申请日：2011-12-30
申请人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号： G06Q50/24
摘要： Structures and protocols are presented for signaling a decision (processing or transmitting a medical record or other resource, e.g.) conditionally, at least partly based on one or more performance indicia (excess hospital readmissions, e.g.) or therapeutic determinants (prior success, e.g.) or privacy considerations (patient consent, e.g.).
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64.发明申请MULTI-LAYER INSULATION COMPOSITE MATERIAL INCLUDING BANDGAP MATERIAL, STORAGE CONTAINER USING SAME, AND RELATED METHODS 失效多层绝缘复合材料，包括带状材料，使用其的储存容器及相关方法公开(公告)号：US20120240524A1
公开(公告)日：2012-09-27
申请号：US13489058
申请日：2012-06-05
申请人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
发明人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
CPC分类号： B65D81/3823 , B65D2203/10
摘要： In one embodiment, a multi-layer insulation (MLI) composite material includes a first thermally-reflective layer and a second thermally-reflective layer spaced from the first thermally-reflective layer. At least one of the first or second thermally-reflective layers includes bandgap material that is reflective to infrared electromagnetic radiation. A region between the first and second thermally-reflective layers impedes heat conduction between the first and second thermally-reflective layers. Other embodiments include a storage container including a container structure that may be at least partially formed from such MLI composite materials, and methods of using such MLI composite materials.
摘要翻译： 在一个实施例中，多层绝缘（MLI）复合材料包括与第一热反射层间隔开的第一热反射层和第二热反射层。 第一或第二热反射层中的至少一个包括反射红外电磁辐射的带隙材料。 第一和第二热反射层之间的区域阻止第一和第二热反射层之间的热传导。 其他实施方案包括存储容器，其包括可以由这种MLI复合材料至少部分形成的容器结构，以及使用这种MLI复合材料的方法。
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65.发明申请Multi-layer insulation composite material including bandgap material, storage container using same, and related methods 有权多层绝缘复合材料包括带隙材料，储存容器使用方法及相关方法公开(公告)号：US20090286022A1
公开(公告)日：2009-11-19
申请号：US12152467
申请日：2008-05-13
申请人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
发明人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
CPC分类号： B65D81/3823 , B65D2203/10
摘要： In one embodiment, a multi-layer insulation (MLI) composite material includes a first thermally-reflective layer and a second thermally-reflective layer spaced from the first thermally-reflective layer. At least one of the first or second thermally-reflective layers includes bandgap material that is reflective to infrared electromagnetic radiation. A region between the first and second thermally-reflective layers impedes heat conduction between the first and second thermally-reflective layers. Other embodiments include a storage container including a container structure that may be at least partially formed from such MLI composite materials, and methods of using such MLI composite materials.
摘要翻译： 在一个实施例中，多层绝缘（MLI）复合材料包括与第一热反射层间隔开的第一热反射层和第二热反射层。 第一或第二热反射层中的至少一个包括反射红外电磁辐射的带隙材料。 第一和第二热反射层之间的区域阻止第一和第二热反射层之间的热传导。 其他实施方案包括存储容器，其包括可以由这种MLI复合材料至少部分形成的容器结构，以及使用这种MLI复合材料的方法。
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公开(公告)号：US20130173298A1
公开(公告)日：2013-07-04
申请号：US13374750
申请日：2012-01-09
申请人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
摘要： Structures and protocols are presented for signaling a decision (processing or transmitting a medical record or other resource, e.g.) conditionally, at least partly based on one or more performance indicia (excess hospital readmissions, e.g.) or therapeutic determinants (prior success, e.g.) or privacy considerations (patient consent, e.g.).
摘要翻译： 至少部分地基于一个或多个性能标记（例如多余的医院重新入院，例如）或治疗决定因素（先前的成功例如）来呈现用于发信号通知决定（例如，有条件地处理或传送医疗记录或其他资源，例如）的结构和协议 或隐私考虑（例如患者同意）。
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67.发明申请Storage container including multi-layer insulation composite material having bandgap material and related methods 失效储存容器包括具有带隙材料的多层绝缘复合材料及相关方法公开(公告)号：US20090283534A1
公开(公告)日：2009-11-19
申请号：US12152465
申请日：2008-05-13
申请人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
发明人： Jeffrey A. Bowers , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
CPC分类号： H04B1/02 , B65D81/3823 , B65D81/3834 , B65D81/3846 , B65D81/3874 , G08C17/02 , H04B1/06 , Y10T428/1376
摘要： In one embodiment, a storage container includes a container structure defining at least one storage chamber. The container structure includes multi-layer insulation (MLI) composite material having at least one thermally-reflective layer. The at least one thermally-reflective layer includes bandgap material that is transmissive to radio-frequency electromagnetic radiation.
摘要翻译： 在一个实施例中，存储容器包括限定至少一个储存室的容器结构。 容器结构包括具有至少一个热反射层的多层绝缘（MLI）复合材料。 所述至少一个热反射层包括对射频电磁辐射透射的带隙材料。
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公开(公告)号：US20130173294A1
公开(公告)日：2013-07-04
申请号：US13374744
申请日：2012-01-09
申请人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Royce A. Levien , Richard T. Lord , Robert W. Lord , Mark A. Malamud , John D. Rinaldo, JR. , Dennis J. Rivet , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号： G06Q50/24
摘要： Structures and protocols are presented for signaling a decision (processing or transmitting a medical record or other resource, e.g.) conditionally, at least partly based on one or more performance indicia (excess hospital readmissions, e.g.) or therapeutic determinants (prior success, e.g.) or privacy considerations (patient consent, e.g.).
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公开(公告)号：US20100104848A1
公开(公告)日：2010-04-29
申请号：US12291840
申请日：2008-11-12
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
IPC分类号： B32B5/18
CPC分类号： B29C67/202 , B29D11/00 , Y10T428/249953
摘要： Articles having porous or foam-like elements are provided. The design, fabrication and structures of the articles exploit properties of reactive composite materials (RCM) and their reaction products. In particular, fluids generated by reacting RCM are utilized to create or fill voids in the porous or foam-like elements.
摘要翻译： 提供具有多孔或泡沫状元件的制品。 制品的设计，制造和结构利用反应性复合材料（RCM）及其反应产物的性质。 特别地，通过使RCM反应产生的流体用于产生或填充多孔或泡沫状元素中的空隙。
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公开(公告)号：US20110278957A1
公开(公告)日：2011-11-17
申请号：US12800250
申请日：2010-05-11
申请人： Philip Andrew Eckhoff , William Gates , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Erez Lieberman , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人： Philip Andrew Eckhoff , William Gates , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Erez Lieberman , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, JR.
CPC分类号： A61B17/320068 , A61B18/1442 , A61B18/1815 , A61B18/20 , A61B90/53 , A61B2017/00734 , A61B2017/320069 , A61B2018/1226 , H02J5/005 , H02J7/025 , H02J17/00 , H02J50/00 , H02J50/12 , H02J50/15 , H02J50/20 , H02J50/30
摘要： Described embodiments include a system, an apparatus, and a method. A described system includes a portable energy source configured to supply electrical or radiant power and configured to be carried proximate to a first body portion of a health care provider. The system also includes a power-output connector configured to releasably couple with a power-receiving connector connected to a handheld medical device, the power-output connector configured to be carried proximate to a second body portion at a position distal of a shoulder joint of the health care provider. If coupled, the power-output connector and the power-receiving connector are operable to transfer the electrical or radiant power supplied by the portable energy source. The system further includes a connective structure configured to transfer the electrical or radiant power supplied by the portable energy source between the portable energy source and the power-output connector.
摘要翻译： 所描述的实施例包括系统，装置和方法。 所描述的系统包括被配置为提供电或辐射功率并被配置为靠近医疗保健提供者的第一身体部分地携带的便携式能量源。 该系统还包括被配置为可释放地与连接到手持式医疗装置的电力接收连接器耦合的电力输出连接器，该电力输出连接器构造成在第二主体部分靠近肩部关节 医疗保健提供者。 如果耦合，则电力输出连接器和电力接收连接器可操作以传送由便携式能量源提供的电力或辐射功率。 该系统还包括结构化结构，其被配置为将由便携式能量源提供的电或辐射功率传送到便携式能量源和功率输出连接器之间。
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