摘要:
Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要:
Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump coupled to the mixing channel to circulate the analyte solution through the reaction chamber and the mixing channel, and an input port in fluid communication with the mixing channel and the reaction chamber to supply the analyte solution to the microfluidic system. The input port can be closed to create a closed circulation path for the analyte solution through the reaction chamber and the mixing channel.
摘要:
A blender jar defines a geometry to impart vertical movement to material being processed in the blender jar, and, alternatively or in combination, improves the horizontal movement to the blended material. By configuring one or more agitators on the floor of a jar, laminar flow or symmetric flow of material around the jar is disrupted. The material is forced in an upward direction in the jar and, therefore, into more frequent contact with the cutter blades rotating in the jar.
摘要:
The present invention relates to HVAC units with condensate drainage systems, for use in motorized vehicles. The present invention provides for at least two or dual condensate drain paths with no extra parts required pre-distribution of the treated air from the HVAC unit, the drainage means or channel situated to allow condensate to ‘fall back’ or, to run upstream back from the evaporator in the opposite direction to the air in the main airflow or stream which continues to run downstream from the drainage area to be conditioned by the heat exchanger.
摘要:
Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要:
A compartmented cooking device for simultaneously cooking a plurality of articles on a flat heated surface has an outer wall around the perimeter of an area and at least one internal wall within the area for defining a plurality of compartments for receiving a material to be cooked and for maintaining the material separately on the heated surface. The compartments can be all of substantially equal area and shape, such as square, rectangular, triangular, rhomboid, trapezoid, circular, oval or any other shape, and are all open from both an upward direction and a downward direction. The walls of each compartment should have at least one marking thereon for delineating a desired level for insertion of material to be cooked. The device also has a handle for allowing it to be lifted off the griddle without a user having to touch the walls of the device.
摘要:
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR.sup.8 (R.sup.8 is H or C.sub.1-6 alkyl); R.sup.1 is H, optionally substituted C.sub.1-6 alkyl, phenyl(C.sub.1-4 alkyl), C.sub.2-6 alkylene, COR.sup.a, COOR.sup.a, CONHR.sup.a, COC.sub.1-4 alkylNR.sup.a R.sup.b, or CONR.sup.a C.sub.1-4 alkylCONR.sup.a R.sup.b ; R.sup.2 is C.sub.1-4 alkyl substituted by an optionally substituted aromatic heterocycle; R.sup.3 is H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; R.sup.4 is H, C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.5 represents optionally substituted phenyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy. ##STR1##
摘要翻译:式(I)化合物及其盐和前药,其中Q表示苯基或二苯甲基; X和Y各自表示H或X和Y一起形成基团= 0; Z是O,S或NR8(R8是H或C1-6烷基); R 1是H,任选取代的C 1-6烷基,苯基(C 1-4烷基),C 2-6亚烷基,CORa,COORA,CONHRa,COC 1-4烷基NR a R b或CONR a C 1-4烷基CONR a R b; R2是被任选取代的芳族杂环取代的C 1-4烷基; R3是H,C1-6烷基或C2-6烯基; R4是H,C1-6烷基或任选取代的苯基; R5代表任选取代的苯基; q为0,1,2或3; 是用于治疗的速激肽拮抗剂。 (一)