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公开(公告)号：US20070213329A1
公开(公告)日：2007-09-13
申请号：US11788888
申请日：2007-04-23
申请人： Jose Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Andrew Owens , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人： Jose Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Andrew Owens , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号： A61K31/535 , A61K31/41 , A61K31/435 , A61K31/498
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了式I的新型砜：其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US20080045533A1
公开(公告)日：2008-02-21
申请号：US11975214
申请日：2007-10-18
申请人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号： A61K31/10 , A61K31/165 , A61K31/41 , A61K31/445 , A61K31/5375 , A61P25/28 , C07C317/14 , C07C381/00 , C07D211/18 , C07D249/08 , C07D265/30
CPC分类号： C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/54 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要： Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了式I的新型砜：该化合物通过γ-分泌酶调节淀粉样蛋白前体蛋白的加工，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US20060041020A1
公开(公告)日：2006-02-23
申请号：US11261365
申请日：2005-10-28
申请人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号： A61K31/655 , A61K31/275 , A61K31/19
CPC分类号： C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要： Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号：US07304094B2
公开(公告)日：2007-12-04
申请号：US11261365
申请日：2005-10-28
申请人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
发明人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
IPC分类号： A61K31/165 , C07C321/24
CPC分类号： C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要： Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公式I的新型手机被公开：
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公开(公告)号：US06984663B2
公开(公告)日：2006-01-10
申请号：US10223993
申请日：2002-08-20
申请人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
发明人： Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams , Brian John Williams
IPC分类号： A61K31/19 , C07C317/12 , C07C317/14
CPC分类号： C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要： Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了式I的新型砜：该化合物通过γ-分泌酶调节淀粉样蛋白前体蛋白的加工，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US07598386B2
公开(公告)日：2009-10-06
申请号：US11788888
申请日：2007-04-23
申请人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号： C07D211/00 , C07D211/68 , C07D211/40 , C07D211/70 , C07D309/00
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了式I的新型砜：其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US06890956B2
公开(公告)日：2005-05-10
申请号：US10679902
申请日：2003-10-06
申请人： Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
发明人： Ian Churcher , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Andrew Pate Owens , Duncan Edward Shaw , Joanne Thomson , Susannah Williams
IPC分类号： A61K31/10 , A61P25/28 , C07C317/30 , C07D213/70 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/02 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34 , A61K31/18 , C07C323/23
CPC分类号： C07D213/70 , A61K31/10 , C07C317/30 , C07C2601/14 , C07D213/74 , C07D231/18 , C07D233/42 , C07D249/12 , C07D257/04 , C07D261/10 , C07D275/03 , C07D277/36 , C07D295/088 , C07D307/64 , C07D333/34
摘要： Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
摘要翻译： 式I化合物：通过γ-分泌酶抑制APP的加工，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US07595344B2
公开(公告)日：2009-09-29
申请号：US12151296
申请日：2008-05-06
申请人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号： A61K31/65
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译： 公开了调节γ-分泌酶作用的唾液。 该化合物可用于治疗或预防阿尔茨海默病。
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公开(公告)号：US20090131419A1
公开(公告)日：2009-05-21
申请号：US12151296
申请日：2008-05-06
申请人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人： Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号： A61K31/54 , C07C317/14 , A61K31/10 , C07D295/14 , A61P25/28 , C07D241/04 , A61K31/495
CPC分类号： C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要： Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号：US07101895B2
公开(公告)日：2006-09-05
申请号：US10679557
申请日：2003-10-06
申请人： Ian Churcher , Timothy Harrison , Sonia Kerrad , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams
发明人： Ian Churcher , Timothy Harrison , Sonia Kerrad , Paul Joseph Oakley , Duncan Edward Shaw , Martin Richard Teall , Susannah Williams
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D213/70 , C07C317/14 , C07C317/18 , C07C317/20 , C07C317/22 , C07C317/24 , C07C317/44 , C07C331/04 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/48 , C07D211/96 , C07D213/71 , C07D213/89 , C07D233/84 , C07D239/38 , C07D249/12 , C07D257/04 , C07D277/36 , C07D285/125 , C07D295/088 , C07D295/26 , C07D307/38 , C07D307/46 , C07D307/52 , C07D307/64 , C07D307/68 , C07D317/46 , C07D333/18 , C07D333/48 , C07D491/08
摘要： Compounds of formula I: wherein Ar1 and Ar2 are optionally substituted aryl or heteroaryl, L is a bond, ═CH— or —(CHRa)n—, and X is SCN, SR1, S(O)R1, (CRaRb)mSO2R1, SO2N(R2)2, SO2NHCOR1, SO2NHN(R2)2, OSO2N(R2)2, OS(O)N(R2)2, OSO2NHCOR1, COR4, NHCOR1, NHCO2R1, NHCON(R2)2, NHSO2R1 or NHSO2N(R2)2, inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.
摘要翻译： 式I的化合物：其中Ar 1和Ar 2是任选取代的芳基或杂芳基，L是键，-CH-或 - （CHR） S（O）R 1，S（O）R 1，...，S（O）R 1， SO 2 SO 2 SO 2，SO 2 N（N，N） R 2，N 2，NH 2，NH 2，NH 2（R 2） 2 O 2，OSO 2 N（R 2）2，OS（ O）N（R 2）2，OSO 2，NHCOR 1，COR 4， ，NHCOR 1，NHCO 2 R 1，NHCON（R 2）2，/ SUB >，NHSO 2 R 1，或NHSO 2 N（R 2）2， ，通过γ分泌酶抑制APP的处理，因此可用于治疗阿尔茨海默氏病。
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