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公开(公告)号:US20070213329A1
公开(公告)日:2007-09-13
申请号:US11788888
申请日:2007-04-23
申请人: Jose Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Andrew Owens , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人: Jose Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Andrew Owens , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号: A61K31/535 , A61K31/41 , A61K31/435 , A61K31/498
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US20080045533A1
公开(公告)日:2008-02-21
申请号:US11975214
申请日:2007-10-18
申请人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号: A61K31/10 , A61K31/165 , A61K31/41 , A61K31/445 , A61K31/5375 , A61P25/28 , C07C317/14 , C07C381/00 , C07D211/18 , C07D249/08 , C07D265/30
CPC分类号: C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/54 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:该化合物通过γ-分泌酶调节淀粉样蛋白前体蛋白的加工,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US20060041020A1
公开(公告)日:2006-02-23
申请号:US11261365
申请日:2005-10-28
申请人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
发明人: Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan Nadin , Paul Oakley , Duncan Shaw , Martin Teall , Susannah Williams , Brian Williams
IPC分类号: A61K31/655 , A61K31/275 , A61K31/19
CPC分类号: C07D213/40 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/27 , C07D207/404 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/72 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/44 , C07D271/06 , C07D271/10 , C07D277/26 , C07D285/12 , C07D295/096 , C07D295/185
摘要: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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公开(公告)号:US20080045515A1
公开(公告)日:2008-02-21
申请号:US11888450
申请日:2007-08-01
申请人: Kevin Dinnell , Timothy Harrison , Alan Nadin , Andrew Owens , Duncan Shaw , Brian Williams
发明人: Kevin Dinnell , Timothy Harrison , Alan Nadin , Andrew Owens , Duncan Shaw , Brian Williams
IPC分类号: A61K31/54 , A61P25/00 , C07D279/02
CPC分类号: C07D279/02
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 式I化合物:通过γ-分泌酶抑制APP的加工,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US20050075320A1
公开(公告)日:2005-04-07
申请号:US10957251
申请日:2004-10-01
申请人: Alan Nadin , Andrew Owens , Martin Teall
发明人: Alan Nadin , Andrew Owens , Martin Teall
IPC分类号: C07C311/14 , C07D207/48 , C07D211/96 , C07D409/12 , A61K31/54 , A61K31/195 , A61K31/277 , A61K31/397 , A61K31/4015 , A61K31/455 , A61K31/537
CPC分类号: C07C311/14 , C07C2601/14 , C07D207/48 , C07D211/96 , C07D409/12
摘要: Compounds of formula I: inhibit the processing of APP by gamma-secretase and hence find use in treatment of Alzheimer's disease.
摘要翻译: 式I化合物:通过γ-分泌酶抑制APP的加工,因此可用于治疗阿尔茨海默氏病。
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公开(公告)号:US20090247504A1
公开(公告)日:2009-10-01
申请号:US12223415
申请日:2007-02-02
申请人: Ian Churcher , Hedaythul Choudhury , Neil Wilkie , Peter Hunt , Richard Jelley , Alan Nadin , Carmel Nanthakumar , Peter Simpson
发明人: Ian Churcher , Hedaythul Choudhury , Neil Wilkie , Peter Hunt , Richard Jelley , Alan Nadin , Carmel Nanthakumar , Peter Simpson
IPC分类号: A61K31/416 , A61K31/5377 , A61K31/397 , C07D231/56 , C07D413/14 , A61P25/28
CPC分类号: A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10
摘要: Compounds of formula (IA) and (IB) are inhibitors of MARK, and hence are suitable for treatment of Alzheimer's disease.
摘要翻译: 式(IA)和(IB)的化合物是MARK的抑制剂,因此适用于治疗阿尔茨海默氏病。
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公开(公告)号:US6133255A
公开(公告)日:2000-10-17
申请号:US381988
申请日:1999-09-27
申请人: Timothy Harrison , Richard Thomas Lewis , Christopher Richard Moyes , Alan Nadin , Andrew Pate Owens
发明人: Timothy Harrison , Richard Thomas Lewis , Christopher Richard Moyes , Alan Nadin , Andrew Pate Owens
IPC分类号: A61K31/4375 , A61K31/4745 , A61K31/55 , A61P25/00 , A61P25/08 , A61P25/22 , A61P43/00 , C07D471/04 , C07D471/14 , A61K31/435
CPC分类号: C07D471/04 , C07D471/14
摘要: Tricyclic pyridin-2-one analogues which are ligands for GABA.sub.A receptors, are useful in the therapy of deleterious mendtal states, and are represented by the formula: ##STR1##
摘要翻译: PCT No.PCT / GB98 / 01167 371 1999年9月27日第 102(e)1999年9月27日PCT提交1998年4月22日PCT公布。 出版物WO98 / 50384 日期1998年11月12日作为GABA A受体的配体的三环吡啶-2-酮类似物可用于治疗有害的门塔状态,并由下式表示:
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