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公开(公告)号：US20250026744A1
公开(公告)日：2025-01-23
申请号：US18747316
申请日：2024-06-18
Applicant: Gilead Sciences, Inc.
Inventor： Peter A. Blomgren , Kevin S. Currie , Morin Mae Frick , Elizabeth M. Horstman , Joshua A. Kaplan , Jeffrey E. Kropf , William J. Watkins
IPC: C07D413/14 , A61K31/397 , A61K31/4439 , A61K31/519 , A61K31/53 , A61P1/16
Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
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公开(公告)号：US20240254137A1
公开(公告)日：2024-08-01
申请号：US18534800
申请日：2023-12-11
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D498/04 , C07B59/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
CPC classification number: C07D498/04 , C07B59/002 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07B2200/05
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20240101529A1
公开(公告)日：2024-03-28
申请号：US18319846
申请日：2023-05-18
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Katherine De La Fuente , Thomas P. Stratton , Peiyuan Wang , William J. Watkins , Jie Xu , Kin S. Yang
IPC: C07D401/10 , C07D403/10 , C07D417/10 , C07D413/10 , C07D405/14 , C07D209/08 , C07D405/06 , A61P31/22
CPC classification number: C07D401/10 , C07D403/10 , C07D417/10 , C07D413/10 , C07D405/14 , C07D209/08 , C07D405/06 , A61P31/22
Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.
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公开(公告)号：US20230374036A1
公开(公告)日：2023-11-23
申请号：US18303813
申请日：2023-04-20
Applicant: Gilead Sciences, Inc.
Inventor： Chaodi Dai , Juan A. Guerrero , Tezcan Guney , Hongyan Guo , Darryl Kato , Irene N. Kiburu , Scott E. Lazerwith , Jessica L. McKinley , Jonathan William Medley , Hyung-Jung Pyun , Maoqun Tian , Vickie H. Tsui , William J. Watkins , Adam D. Zajdlik , Jennifer R. Zhang
IPC: C07D498/22 , C07D471/22 , C07F7/10
CPC classification number: C07D498/22 , C07D471/22 , C07F7/10
Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
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公开(公告)号：US20230373950A1
公开(公告)日：2023-11-23
申请号：US18184335
申请日：2023-03-15
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
IPC: C07D401/04
CPC classification number: C07D401/04 , C07B2200/05
Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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Patent Agency Ranking
公开(公告)号：US11787825B2
公开(公告)日：2023-10-17
申请号：US18061375
申请日：2022-12-02
Applicant: Gilead Sciences, Inc.
Inventor： Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B. C. Mack , William J. Watkins
IPC: C07F9/09
CPC classification number: C07F9/095
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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公开(公告)号：US20230212155A1
公开(公告)日：2023-07-06
申请号：US18060934
申请日：2022-12-01
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00
CPC classification number: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/2818
Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US11225473B2
公开(公告)日：2022-01-18
申请号：US16741101
申请日：2020-01-13
Applicant: Gilead Sciences, Inc.
Inventor： Peter A. Blomgren , Kevin S. Currie , Morin Mae Frick , Elizabeth M. Horstman , Joshua A. Kaplan , Jeffrey E. Kropf , William J. Watkins
IPC: C07D413/14 , A61K31/4439 , A61P1/16 , A61K31/519 , A61K31/53 , A61K31/397
Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
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公开(公告)号：US10703733B2
公开(公告)日：2020-07-07
申请号：US16410457
申请日：2019-05-13
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D513/08 , C07D267/20 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , A61K45/06
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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公开(公告)号：US20190352271A1
公开(公告)日：2019-11-21
申请号：US16410457
申请日：2019-05-13
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D267/20 , C07D413/12 , C07D471/04 , C07D417/12 , C07D487/04 , C07D498/04 , C07D413/14
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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