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61.发明授权公开(公告)号：US08906608B2
公开(公告)日：2014-12-09
申请号：US11495842
申请日：2006-07-28
Applicant: Egisto Boschetti , David Hammond
Inventor： Egisto Boschetti , David Hammond
CPC classification number: G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。
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62.发明授权公开(公告)号：US07670592B2
公开(公告)日：2010-03-02
申请号：US12348867
申请日：2009-01-05
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: A61K49/00
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US07591993B2
公开(公告)日：2009-09-22
申请号：US10692785
申请日：2003-10-27
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US20090179146A1
公开(公告)日：2009-07-16
申请号：US11915151
申请日：2006-01-19
Applicant: Lee O. Lomas , Jian Ding , Egisto Boschetti
Inventor： Lee O. Lomas , Jian Ding , Egisto Boschetti
CPC classification number: G01N30/461 , B01D15/325 , B01D15/362 , B01D15/363 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/026 , B01L2200/028 , B01L2300/0681 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , C07K1/34 , G01N27/44704 , G01N27/44795 , G01N30/466 , G01N30/468 , Y10T137/2224 , Y10T137/794 , Y10T137/86187 , Y10T436/255
Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.
Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。
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65.发明申请公开(公告)号：US20070065953A1
公开(公告)日：2007-03-22
申请号：US11495842
申请日：2006-07-28
Applicant: Egisto Boschetti , David Hammond
Inventor： Egisto Boschetti , David Hammond
CPC classification number: G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒
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Patent Agency Ranking
公开(公告)号：US07183544B2
公开(公告)日：2007-02-27
申请号：US11014225
申请日：2004-12-17
Applicant: Egisto Boschetti , Luc Bourgeois
Inventor： Egisto Boschetti , Luc Bourgeois
CPC classification number: B01J39/26 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J41/20 , B01J47/016 , B01J2220/54 , G01N33/54393 , G01N33/6851
Abstract: In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.
Abstract translation: 关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。 第一层附着有第二聚合物层，其特征在于相反的电荷。
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67.发明申请Separation of proteins based on isoelectric point using solid-phase buffers 审中-公开使用固相缓冲液分离基于等电点的蛋白质公开(公告)号：US20070039891A1
公开(公告)日：2007-02-22
申请号：US11493923
申请日：2006-07-27
Applicant: Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
Inventor： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
IPC: B01D15/08
CPC classification number: B01D15/362 , B01D15/1871 , B01D15/36 , B01D15/363 , B01J20/28033 , B01J39/26 , B01J41/20 , B01J47/018 , B01J2220/603 , B01J2220/82 , C07K1/18 , G01N30/461
Abstract: Proteins can be separated from mixtures, based on their pI values, through the use of a series of chromatographic materials, each comprising a solid buffer and an ion exchange resin. Each solid buffer generates a stable pH, such that passing proteins possess a net charge and can be separated by means of an appropriate ion exchanger. In this fashion, proteins from complex biological fluids can be separated for identification and study.
Abstract translation: 通过使用一系列色谱材料，每种包含固体缓冲液和离子交换树脂，蛋白质可以基于其pI值与混合物分离。 每个固体缓冲液产生稳定的pH，使得通过的蛋白质具有净电荷并且可以通过合适的离子交换剂分离。 以这种方式，可以分离来自复杂生物流体的蛋白质进行鉴定和研究。
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公开(公告)号：US20060216751A1
公开(公告)日：2006-09-28
申请号：US11388181
申请日：2006-03-22
Applicant: Egisto Boschetti , Lee Lomas
Inventor： Egisto Boschetti , Lee Lomas
Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.
Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，结合污染蛋白质和少数靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。
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公开(公告)号：US06680046B1
公开(公告)日：2004-01-20
申请号：US09419114
申请日：1999-10-15
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: A61K4900
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及一种生产聚乙烯基苯乙醇微球的方法。
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70.发明授权Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子
公开(公告)号：US5906747A
公开(公告)日：1999-05-25
申请号：US556313
申请日：1995-11-13
Applicant: Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
Inventor： Jonathan L. Coffman , Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/08 , B01D15/361 , C07K1/18
Abstract: This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。 特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。 为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的 与生物分子的非特异性相互作用。
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