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    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
    1.
    发明授权
    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效
    使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子

    公开(公告)号：US5906747A

    公开(公告)日：1999-05-25

    申请号：US556313

    申请日：1995-11-13

    申请人： Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    发明人： Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    IPC分类号： B01D15/08 ,  C07K1/18

    CPC分类号： B01D15/08 ,  B01D15/361 ,  C07K1/18

    摘要： This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.

    摘要翻译： 本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。 特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。 为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的 与生物分子的非特异性相互作用。

    Multi-compartment filter and method of filtering using same
    6.
    发明授权
    Multi-compartment filter and method of filtering using same 有权
    多室过滤器和使用其的过滤方法

    公开(公告)号：US07815783B2

    公开(公告)日：2010-10-19

    申请号：US11073999

    申请日：2005-03-08

    申请人： Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    发明人： Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    IPC分类号： G01N27/453 ,  B01D57/02

    CPC分类号： G01N27/44704 ,  B01D57/02 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J2220/54 ,  C07K1/24 ,  C07K1/34 ,  G01N27/44795

    摘要： Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.

    摘要翻译： 每个实施例包括中央样品储存器和多个卫星储存器。 在第一实施例中，与中央储存器电接触的第一电极被充电，并且与卫星储存器电接触的第二电极被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器中。 在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。 在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。 样品中的一些分子被pI过滤到第一和第二卫星储层中。 然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。 样品中的一些分子被pI过滤到第三和第四卫星储层中。