公开(公告)号：US09354751B2

公开(公告)日：2016-05-31

申请号：US12560846

申请日：2009-09-16

申请人： Joseph Fisher ,  Erturk Kocalar ,  Steven Hotelling ,  David Gutierrez

发明人： Joseph Fisher ,  Erturk Kocalar ,  Steven Hotelling ,  David Gutierrez

IPC分类号： G06F3/041 ,  G06F3/044

CPC分类号： G06F3/044 ,  G06F3/0416

摘要： An input device is disclosed that can improve input detection associated with sensor elements that exhibit a weaker response at the lower end of their dynamic range than their counterparts. This can be advantageous when implementing input reporting rules that rely on a sufficient response at the lower end of a sensor element's dynamic range. The input device can compensate for a weak sensor element at the low end of its dynamic range by increasing its sensitivity in certain situations, such as when an adjacent sensor provides a strong input signal, or after the weak sensor element provides a signal level exceeding a noise threshold for example. The sensitivity of the weak sensor element can be increased in a variety of ways, such as by reducing a noise threshold associated with the sensor element or boosting a signal level associated with the sensor element for example.

摘要翻译： 公开了一种输入设备，其可以改进与其动态范围的较低端处的比其对应物呈现较弱响应的传感器元件相关联的输入检测。 当实现依赖于在传感器元件的动态范围的较低端的足够响应的输入报告规则时，这可能是有利的。 输入装置可以通过在某些情况下增加其灵敏度来补偿其动态范围的低端的弱传感器元件，例如当相邻传感器提供强输入信号时，或者在弱传感器元件提供超过 噪声阈值为例。 弱传感器元件的灵敏度可以以各种方式增加，例如通过减少与传感器元件相关联的噪声阈值或增强例如与传感器元件相关联的信号电平。

公开(公告)号：US20160000935A1

公开(公告)日：2016-01-07

申请号：US14324900

申请日：2014-07-07

申请人： Shudong Jiang ,  Joseph Fisher

发明人： Shudong Jiang ,  Joseph Fisher

IPC分类号： A61K49/00

摘要： A method of assessing the susceptibility of a tumor to reduction in hypoxia, comprising delivering oxygen and CO2 to attain a starting end tidal concentration of oxygen (PetO2) between 350 and 450 mm Hg, and a starting end tidal concentration of CO2 (PetCO2) between 42 and 55 mm Hg; changing PetO2 and/or PetCO2, wherein at least one increment of change is maintained for a time sufficient to obtain a surrogate measure of tumor oxygenation reflecting change in tumor oxygenation relative to a previously measured surrogate value of tumor oxygenation, wherein the starting PetO2 and/or an incremental change in PetO2 is approximately between 375 and 425 mm Hg, and wherein the starting PetCO2 and/or an incremental change in PetCO2 is approximately between 42 and 50 mm Hg; and obtaining a surrogate measure of tumor oxygenation after changing PetO2 and/or PetCO2 for comparison to a previously measured surrogate value of tumor oxygenation.

摘要翻译： 一种评估肿瘤减少缺氧的易感性的方法，包括输送氧气和二氧化碳以达到350至450mm Hg之间的起始潮氧浓度（PetO 2）和CO 2的起始潮汐浓度（PetCO 2） 42和55毫米汞柱; 改变PetO2和/或PetCO2，其中至少一个变化增量保持足以获得反映肿瘤氧合反应相对于先前测量的肿瘤氧合替代值的肿瘤氧合的变化的替代测量的时间，其中起始PetO2和/ 或PetO2中的增量变化大约在375至425mm Hg之间，并且其中起始PetCO2和/或PetCO2的增量变化约为42至50mm Hg; 并且在改变PetO2和/或PetCO2之后获得肿瘤氧合的替代量度，以与之前测量的肿瘤氧合替代值进行比较。

公开(公告)号：US20130109978A1

公开(公告)日：2013-05-02

申请号：US13697768

申请日：2011-05-18

申请人： Joseph Fisher ,  Michael Klein ,  James Duffin

发明人： Joseph Fisher ,  Michael Klein ,  James Duffin

IPC分类号： A61B5/0205 ,  A61M16/12 ,  A61M16/00 ,  A61B5/026 ,  A61B5/00

CPC分类号： A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0813 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/7225 ,  A61B5/7278 ,  A61M16/0057 ,  A61M16/12

摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

摘要翻译： 一种使用迭代算法控制气体输送装置的方法，所述装置可控变量使用迭代算法递送用于非侵入性地确定受试者的肺血流的测试气体（TG），包括迭代生成并评估迭代变量的测试值 算法，以输出满足测试标准的迭代变量的测试值，其中迭代算法的特征在于它定义了至少一个设备可控变量，迭代变量和获得的测试气体的终止潮汐浓度之间的测试数学关系 通过设置设备可控变量，使得迭代算法确定测试值上的迭代是否满足测试标准或迭代地生成逐渐改进的测试值。

公开(公告)号：US08403224B2

公开(公告)日：2013-03-26

申请号：US12015809

申请日：2008-01-17

申请人： Ludwik Fedorko ,  Joseph Fisher ,  Bryan Drew Miller ,  Bryan Kowalchuk

发明人： Ludwik Fedorko ,  Joseph Fisher ,  Bryan Drew Miller ,  Bryan Kowalchuk

IPC分类号： G06K7/10

CPC分类号： G06F19/327 ,  A61J1/14 ,  A61J1/2003 ,  A61J2205/10 ,  A61J2205/20 ,  A61J2205/30 ,  A61J2205/70 ,  A61M2205/6072 ,  A61M2205/6081 ,  G06F19/00 ,  G06F19/3456 ,  G06Q10/00 ,  G06Q10/06 ,  G06Q10/08 ,  G06Q10/0875 ,  G06Q50/22 ,  G16H40/20

摘要： The invention relates to a system and method for tracking drugs during a transfer and administering process to reduce labeling errors that can occur during that process. The system includes a storage container reader that is configured to read a set of one or more storage-container-associated machine-readable indicia positioned on a container containing a drug. The set of one or more storage-container-associated machine-readable indicia identifies the drug. The system further includes an indicia-generating device that is configured to generate a drug-delivery-container-associated indicia identifying the drug based on the storage-container-associated machine-readable indicia. The set of one or more drug-delivery-container-associated indicia includes a set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes a drug delivery container reader, wherein the drug delivery container reader is configured to read the set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes a processing unit that generates an output signal corresponding to the drug based on the set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes an output device that outputs a user-comprehensible output identifying the drug based on the output signal from the processing unit.

摘要翻译： 本发明涉及用于在转移和施用过程中跟踪药物以减少在该过程中可能发生的标记错误的系统和方法。 该系统包括存储容器读取器，其被配置为读取位于容纳药物的容器上的一组一个或多个存储容器相关的机器可读标记。 一个或多个存储容器相关联的机器可读标记的集合识别该药物。 该系统还包括标记产生装置，其被配置为基于与存储容器相关联的机器可读标记来生成识别药物的药物递送 - 容器相关标记。 该组一个或多个药物递送 - 容器相关的标记包括一组一个或多个药物递送 - 容器相关联的机器可读标记。 任选地，系统还包括药物递送容器读取器，其中药物递送容器读取器被配置为读取一组或多个药物递送 - 容器相关联的机器可读标记。 可选地，系统还包括处理单元，其基于一个或多个药物递送 - 容器相关联的机器可读标记的集合生成与药物相对应的输出信号。 可选地，系统还包括输出装置，其基于来自处理单元的输出信号输出识别药物的用户可理解的输出。

公开(公告)号：US20100289759A1

公开(公告)日：2010-11-18

申请号：US12560846

申请日：2009-09-16

申请人： Joseph Fisher ,  Erturk Kocalar ,  Steven Hotelling ,  David Gutierrez

发明人： Joseph Fisher ,  Erturk Kocalar ,  Steven Hotelling ,  David Gutierrez

IPC分类号： G06F3/041

CPC分类号： G06F3/044 ,  G06F3/0416

摘要： An input device is disclosed that can improve input detection associated with sensor elements that exhibit a weaker response at the lower end of their dynamic range than their counterparts. This can be advantageous when implementing input reporting rules that rely on a sufficient response at the lower end of a sensor element's dynamic range. The input device can compensate for a weak sensor element at the low end of its dynamic range by increasing its sensitivity in certain situations, such as when an adjacent sensor provides a strong input signal, or after the weak sensor element provides a signal level exceeding a noise threshold for example. The sensitivity of the weak sensor element can be increased in a variety of ways, such as by reducing a noise threshold associated with the sensor element or boosting a signal level associated with the sensor element for example.

摘要翻译： 公开了一种输入设备，其可以改进与其动态范围的较低端处的比其对应物呈现较弱响应的传感器元件相关联的输入检测。 当实现依赖于在传感器元件的动态范围的较低端的足够响应的输入报告规则时，这可能是有利的。 输入装置可以通过在某些情况下增加其灵敏度来补偿其动态范围的低端的弱传感器元件，例如当相邻传感器提供强输入信号时，或者在弱传感器元件提供超过 噪声阈值为例。 弱传感器元件的灵敏度可以以各种方式增加，例如通过减少与传感器元件相关联的噪声阈值或增强例如与传感器元件相关联的信号电平。

公开(公告)号：US20100163046A1

公开(公告)日：2010-07-01

申请号：US12294669

申请日：2007-03-28

申请人： Joseph Fisher ,  Ludwik Fedorko ,  Edward Masionis ,  Bryan Kowalchuk ,  George Volgyesi

发明人： Joseph Fisher ,  Ludwik Fedorko ,  Edward Masionis ,  Bryan Kowalchuk ,  George Volgyesi

IPC分类号： A61M16/00

CPC分类号： A61M16/107 ,  A61M16/0045 ,  A61M16/0066 ,  A61M16/0075 ,  A61M16/0078 ,  A61M16/0081 ,  A61M16/021 ,  A61M16/08 ,  A61M16/12 ,  A62B18/006

摘要： A CPAP device and method are provided. The CPAP device includes an inspiratory reservoir, a positive pressure air source, and a pressurizing device. The inspiratory reservoir is fluidically connectable with at least one breathing orifice of a user. The positive pressure air source is fluidically connectable to the inspiratory reservoir. The pressurizing device is movable from a first position to a second position by releasing stored potential energy. During movement to the second position the pressurizing device applies a generally constant pressure to gas contained in the inspiratory reservoir. The pressurizing device is both movable towards the first position and augmentable in stored potential energy by pressure from exhalation air from the user.

摘要翻译： 提供CPAP设备和方法。 CPAP装置包括吸气容器，正压空气源和加压装置。 吸气容器可与使用者的至少一个呼吸孔流体连接。 正压空气源可流体地连接到吸气容器。 加压装置通过释放存储的势能而从第一位置移动到第二位置。 在移动到第二位置期间，加压装置对吸入储存器中包含的气体施加大致恒定的压力。 加压装置可以朝着第一位置移动，并且通过来自使用者的呼出空气的压力而在存储的势能中增加。

公开(公告)号：US07461040B1

公开(公告)日：2008-12-02

申请号：US09633824

申请日：2000-08-07

申请人： Arnold J. Goldman ,  Joseph Fisher ,  Jehuda Hartman ,  Shlomo Sarel

发明人： Arnold J. Goldman ,  Joseph Fisher ,  Jehuda Hartman ,  Shlomo Sarel

IPC分类号： G06N5/00

CPC分类号： G05B13/048

摘要： A strategic method for process control wherein the method includes, for a predetermined process juncture, the steps of: (A) defining an interconnection cell having associated therewith (i) at least one set of input data or at least one set of process control parameters, and (ii) at least one set of output data; (B) assigning at least one boundary value to at least one set of the sets associated with the defined interconnection cell; (C) using the assigned at least one boundary value, forming a plurality of discrete respective set combinations, and (D) for the interconnection cell, processing data from the plurality of respective formed set combinations into respective corresponding data record clusters.The strategic method for process control is a continuation-in-part of a Knowledge-Engineering Protocol-Suite, (U.S. patent application Ser. No. 09/588,681 filed on 7 Jun. 2000) incorporated herein by reference, that generally includes methods and systems, apparatus for search-space organizational validation, and appurtenances for use therewith. The protocol-suite includes a search-space organizational validation method for synergistically combining knowledge bases of disparate resolution data-sets, such as by actual or simulated integrating of lower resolution expert-experience based model-like templates to higher resolution empirical data-capture dense quantitative search-spaces. The protocol-suite includes facile algorithmic tools for use with the method.

摘要翻译： 一种用于过程控制的策略方法，其中该方法包括以下步骤：（A）定义与之相关联的互连单元（i）至少一组输入数据或至少一组过程控制参数 ，和（ii）至少一组输出数据; （B）将至少一个边界值分配给与所述定义的互连小区相关联的至少一组集合; （C）使用分配的至少一个边界值，形成多个离散的各自的集合组合，以及（D）用于所述互连单元，将来自所述多个相应的形成的组合的数据处理成相应的对应的数据记录集群。 过程控制的战略方法是知识工程协议套件（美国专利申请系列号09 / 588,681，2000年6月7日提交）的部分继续，其通过引用并入本文，通常包括方法和 系统，搜索空间组织验证的装置和与其一起使用的附件。 协议套件包括搜索空间组织验证方法，用于协同地组合不同分辨率数据集的知识库，例如通过实际或模拟集成较低分辨率专家经验的模型样模板与更高分辨率经验数据捕获密集 定量搜索空间。 协议套件包括与该方法一起使用的简便的算法工具。

公开(公告)号：US20060152084A1

公开(公告)日：2006-07-13

申请号：US11031547

申请日：2005-01-07

申请人： David Tupman ,  Doug Farrar ,  Joseph Fisher ,  Jesse Dorogusker ,  Donald Novotney

发明人： David Tupman ,  Doug Farrar ,  Joseph Fisher ,  Jesse Dorogusker ,  Donald Novotney

IPC分类号： H02J7/00

CPC分类号： H02J7/0054 ,  Y10T307/406 ,  Y10T307/469 ,  Y10T307/615 ,  Y10T307/826 ,  Y10T307/832

摘要： A portable power source is configured for use with an electronic device. The portable power source cooperates and communicates with the electronic device via a peripheral bus to which the electronic device is attachable. The portable power source includes circuitry to process a power request signal from the electronic device to determine whether a device connected to a bus interface of the portable power source is requesting power from the portable power source.

公开(公告)号：US06952688B1

公开(公告)日：2005-10-04

申请号：US09588681

申请日：2000-06-07

申请人： Arnold J. Goldman ,  Joseph Fisher ,  Jehuda Hartman ,  Shlomo Sarel

发明人： Arnold J. Goldman ,  Joseph Fisher ,  Jehuda Hartman ,  Shlomo Sarel

IPC分类号： G06F20060101 ,  G06N5/00 ,  G06N5/02

CPC分类号： G06N5/022

摘要： A Knowledge-Engineering Protocol-Suite is presented that generally includes methods and systems, apparatus for search-space organizational validation, and appurtenances for use therewith. The protocol-suite includes a search-space organizational validation method for synergistically combining knowledge bases of disparate resolution data-sets, such as by actual or simulated integrating of lower resolution expert-experience based model-like templates to higher resolution empirical data-capture dense quantitative search-spaces. Furthermore, from alternative technological vantages, the suite relates to situations where this synergetic combining is beneficially accomplished, such as in control systems, command control systems, command control communications systems, computational apparatus associated with the aforesaid, and to quantitative modeling and measuring tools used therewith. The protocol-suite also includes facile algorithmic tools for use with the method and a process-modeling computer for use in a distributed asynchronous system of process modeling computers.

摘要翻译： 提出了一种知识工程协议 - 套件，其通常包括方法和系统，用于搜索空间组织验证的装置以及与其一起使用的附件。 协议套件包括搜索空间组织验证方法，用于协同地组合不同分辨率数据集的知识库，例如通过实际或模拟集成较低分辨率专家经验的模型样模板与更高分辨率经验数据捕获密集 定量搜索空间。 此外，从替代技术优势来看，该套件涉及有利地实现这种协同组合的情况，例如在控制系统，命令控制系统，命令控制通信系统，与上述相关的计算设备以及使用的定量建模和测量工具 随之而来。 协议套件还包括与该方法一起使用的便捷的算法工具以及用于流程建模计算机的分布式异步系统中的流程建模计算机。

公开(公告)号：US06728587B2

公开(公告)日：2004-04-27

申请号：US09747977

申请日：2000-12-27

申请人： Arnold J. Goldman ,  Jehuda Hartman ,  Joseph Fisher ,  Shlomo Sarel

发明人： Arnold J. Goldman ,  Jehuda Hartman ,  Joseph Fisher ,  Shlomo Sarel

IPC分类号： G06F1900

CPC分类号： G05B19/41865 ,  G05B2219/31103 ,  G05B2219/31206 ,  G05B2219/32053 ,  G05B2219/32201 ,  Y02P90/16 ,  Y02P90/20 ,  Y02P90/22 ,  Y02P90/26 ,  Y02P90/265

摘要： A method and system to enhance yield in multi-process manufacturing. The method comprising the translation of a performance parameter of a product into input variables to operate tools carrying our cooperating processes which built a structural element which determines the performance parameter, wherein the individual tools are process controlled. The method further comprising the integration of process control of individual separate processes or of stages in a process, into a combined and comprehensive (modular) process control in which the process parameters of a process are enslaved to accomplish the target output of the final process. Hence target output values of intermediate processes are dynamically reassigned during the manufacturing with respect to their initially designed values, in accordance with the output of their cooperating processes.

摘要翻译： 一种提高多工艺制造成品率的方法和系统。 该方法包括将产品的性能参数转换为输入变量以操作承载我们的协作过程的工具，其构建确定性能参数的结构元素，其中各个工具被过程控制。 该方法还包括将过程中的各个单独过程或阶段的过程控制集成到组合和全面（模块化）过程控制中，其中过程的过程参数被强制以完成最终过程的目标输出。 因此，根据其合作过程的输出，中间过程的目标输出值在制造过程中根据其最初设计的值进行动态重新分配。