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公开(公告)号：US20080316858A1
公开(公告)日：2008-12-25
申请号：US11817164
申请日：2006-02-13
CPC分类号： B01J19/2415 , B01F5/061 , B01F11/0071 , B01F11/0082 , B01F2005/0632 , B01F2005/0636 , B01F2015/061 , B01F2215/0037 , B01F2215/0073 , B01J2219/00094
摘要： The present invention relates to an oscillatory flow mixing reactor (OPM) oscillatory flow which is designed so that a flow with angular momentum is superposed by means effecting circular acceleration on the mixture flowing in with oscillation, with the result that good mixing of the individual phases of the mixture is achieved with the use of low shear forces. A use of the reactor according to the invention is also disclosed.
摘要翻译： 本发明涉及一种振荡流混合反应器（OPM）振荡流，其设计成使得具有角动量的流动通过对在振荡中流动的混合物产生圆周加速度而叠加，结果是各个相的混合良好 的混合物通过使用低剪切力来实现。 还公开了根据本发明的反应器的用途。
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公开(公告)号：US07247465B2
公开(公告)日：2007-07-24
申请号：US10559434
申请日：2004-05-15
申请人： Oliver May , Karlheinz Drauz , Stefan Buchholz
发明人： Oliver May , Karlheinz Drauz , Stefan Buchholz
CPC分类号： G01N33/573 , C12N9/90 , C12N11/16 , C12P13/04 , C12P41/009
摘要： The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis.Hydantoin racemases are of interest in connection with the production of enantiomerically enriched amino acids from racemic hydantoins.
摘要翻译： 本发明涉及乙内酰脲消旋酶和新型乙内酰脲消旋酶的筛选方法，编码该核酸序列的核酸序列以及用于诱变的过程。 海参蛋白消旋酶与从外消旋乙内酰脲生产对映体富集的氨基酸有关。
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63.发明申请Process for preparing enantiomer-enriched alpha-hydroxycarboxylic acids and amides 审中-公开制备富含对映异构体的α-羟基羧酸和酰胺的方法公开(公告)号：US20070020741A1
公开(公告)日：2007-01-25
申请号：US10575386
申请日：2004-10-07
申请人： Karlheinz Drauz , Stefan Buchholz , Harald Groger
发明人： Karlheinz Drauz , Stefan Buchholz , Harald Groger
摘要： The present invention describes an enzymatic process for preparing enantiomer-enriched α-hydroxycarboxylic acids and amides which comprises, in one step, the conversion of a carbonyl compound to the corresponding acid/amides via the intermediate stage of a cyanohydrin. The invention also provides a reaction system operating in such a way and a whole-cell catalyst that is advantageous for use for this reaction.
摘要翻译： 本发明描述了制备富含对映异构体的α-羟基羧酸和酰胺的酶促方法，其包括在一步中通过氰醇的中间阶段将羰基化合物转化为相应的酸/酰胺。 本发明还提供了以这种方式操作的反应体系和对于该反应有利的全细胞催化剂。
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公开(公告)号：US20060177914A1
公开(公告)日：2006-08-10
申请号：US10546733
申请日：2004-03-17
CPC分类号： C12N9/0004 , C12N9/00 , C12P7/02
摘要： The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer purities with the aid of a coupled enzymatically operating transformation process. The coupled enzymatically operating reaction system in this context comprises an enzymatic transformation reaction which proceeds with the consumption of a cofactor, and recycling of the cofactor consumed, which proceeds enzymatically, wherein the procedure is carried out in a homogeneous aqueous solvent system comprising an organic hydrocarbon having at least two hydroxyl or ether groups.
摘要翻译： 本申请涉及一种反应体系，其中可以借助于偶联的酶操作转化方法在高对映异构体纯度中获得化学有价值的化合物。 在本文中，偶联的酶促操作反应体系包括酶促转化反应，其在消耗辅因子的情况下进行，并且消耗的辅因子的循环进行，其中该方法在含有有机碳的均相含水溶剂系统中进行 具有至少两个羟基或醚基团。
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公开(公告)号：US06830692B1
公开(公告)日：2004-12-14
申请号：US09399743
申请日：1999-09-20
IPC分类号： B01D6124
CPC分类号： A61K31/195 , A61K2300/00
摘要： The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon cam be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.
摘要翻译： 本发明涉及用于血液透析的特殊氨基酸混合物以及可由氨基酸混合物制备的透析溶液。 当根据本发明的氨基酸混合物用于这些目的时，可以防止“收缩男人”现象。 本发明还涉及血液透析过程和装置。 本发明的该方面提供了一种封闭式透析系统，其具有含有根据本发明的氨基酸混合物的透析器溶液。
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公开(公告)号：US06787039B2
公开(公告)日：2004-09-07
申请号：US09769397
申请日：2001-01-26
IPC分类号： B01D6124
CPC分类号： A61M1/1656 , A61K31/195 , A61K31/401 , A61K31/405 , A61K31/4172 , A61M1/166 , A61M1/1674 , A61K2300/00
摘要： The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon can be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.
摘要翻译： 本发明涉及用于血液透析的特殊氨基酸混合物以及可由氨基酸混合物制备的透析溶液。 当根据本发明的氨基酸混合物用于此目的时，可以防止“收缩男性”现象。 本发明还涉及血液透析过程和装置。 本发明的该方面提供了一种封闭式透析系统，其具有含有根据本发明的氨基酸混合物的透析器溶液。
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67.发明授权Acetyl amino acid racemase from amycolatopsis orientalis for racemizing carbamoyl amino acids 失效用于外消旋化氨基甲酰氨基酸的乙酰氨基酸消旋酶公开(公告)号：US06767725B2
公开(公告)日：2004-07-27
申请号：US09973712
申请日：2001-10-11
IPC分类号： C12P1304
CPC分类号： C12N9/90 , C12P41/009
摘要： The invention relates to the use of the N-acetyl amino acid racemase from Amycolatopsis orientalis subspecies lurida for the racemiszation of N-carbamoyl amino acids. This use permits the 100% preparation of optically pure amino acids starting from racemic hydantoins in an enzymatic overall process.
摘要翻译： 本发明涉及来自山莨菪属亚种的亚乙酰氨基酸消旋酶用于N-氨基甲酰氨基酸的外消旋化的用途。 这种使用允许在酶的总体方法中从外消旋乙内酰脲开始100％制备光学纯氨基酸。
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68.发明授权Use of molecular weight-enlarged catalysts in a process for asymmetric, continous hydrogenation, novel molecular weight-enlarged ligands and catalysts 失效在不对称，连续氢化，新的分子量扩大配体和催化剂的方法中使用分子量增大的催化剂公开(公告)号：US06759559B2
公开(公告)日：2004-07-06
申请号：US09767879
申请日：2001-01-24
申请人： Stephan Laue , Andreas Liese , Christian Wandrey , Olaf Burkhardt , Jens Woeltinger , Andreas Bommarius , Hans Henniges , Jean-Louis Philippe , Andreas Karau , Karlheinz Drauz
发明人： Stephan Laue , Andreas Liese , Christian Wandrey , Olaf Burkhardt , Jens Woeltinger , Andreas Bommarius , Hans Henniges , Jean-Louis Philippe , Andreas Karau , Karlheinz Drauz
IPC分类号： C07C2700
CPC分类号： C07B53/00 , B01J31/1658 , B01J31/1675 , B01J31/1805 , B01J31/182 , B01J31/1875 , B01J31/189 , B01J31/2221 , B01J31/2243 , B01J31/2295 , B01J31/2409 , B01J31/2433 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J31/4061 , B01J2231/643 , B01J2231/645 , B01J2531/0244 , B01J2531/0255 , B01J2531/0263 , B01J2531/0266 , B01J2531/0272 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/845 , B01J2531/847 , Y02P20/584
摘要： The first embodiment of the present invention provides a process, which includes: in a continuous process in a membrane reactor, asymmetrically hydrogenating at least one C═C, C═N or C═O double bond with a catalyst. Another embodiment of the present invention provides a ligand, which includes at least one di-1,3-aminophosphine homochiral active center; optionally, a linker; and a molecular weight-enlarging polymer; wherein the active center is bound to the molecular weight-enlarging polymer through the linker or is bound directly to the molecular weight-enlarging polymer; and wherein the linker is defined in the claims. Another embodiment of the present invention provides a process for preparing the above-noted ligand, and a catalyst that includes the above-noted ligand.
摘要翻译： 本发明的第一个实施方案提供了一种方法，其包括：在膜反应器中的连续方法中，使用催化剂不对称地氢化至少一个C = C，C = N或C = O双键。 本发明的另一个实施方案提供了一种配体，其包含至少一个二-1,3-亚氨基同位素活性中心; 任选地，接头; 和分子量增大的聚合物; 其中活性中心通过接头与分子量增加的聚合物结合或直接结合到分子量增大的聚合物上; 并且其中所述接头在权利要求中限定。 本发明的另一个实施方案提供了制备上述配体的方法和包含上述配体的催化剂。
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69.发明授权公开(公告)号：US06656710B2
公开(公告)日：2003-12-02
申请号：US09973765
申请日：2001-10-11
IPC分类号： C12P1304
CPC分类号： C12P41/007 , C12P13/04 , C12P13/12
摘要： The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
摘要翻译： 本发明涉及酰基转移酶/消旋酶体系中的特殊N-保护氨基酸的外消旋化和脱保护方法，用于将特殊N-保护的外消旋氨基酸总转化成光学纯氨基酸。
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70.发明授权公开(公告)号：US06538105B1
公开(公告)日：2003-03-25
申请号：US09453711
申请日：1999-12-03
申请人： Karlheinz Drauz , Stan M. Roberts , Thomas Geller , Anupma Dhanda
发明人： Karlheinz Drauz , Stan M. Roberts , Thomas Geller , Anupma Dhanda
IPC分类号： C08G6902
CPC分类号： C08G69/10 , B01J21/08 , B01J21/18 , B01J31/0254 , B01J31/061 , B01J31/062 , B01J2231/72 , C07B2200/07 , C07D301/02 , C07D303/32 , C07D405/04
摘要： Compositions are disclosed which comprise a homopolyamino acid and stereoisomers thereof adsorbed on an insoluble support material. The compositions are useful as catalysts for the stereoselective epoxidation of olefins.
摘要翻译： 公开了包含均聚氨基酸和其不溶性载体材料上的立体异构体的组合物。 该组合物可用作烯烃的立体选择性环氧化催化剂。
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