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公开(公告)号：US5929177A
公开(公告)日：1999-07-27
申请号：US11329
申请日：1998-02-05
申请人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
发明人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
IPC分类号： C08G63/06 , A61K9/107 , A61K9/51 , A61K47/34 , C08F297/00 , C08G63/664 , C08G63/676 , C08G63/91 , C08G65/26 , C08G65/329 , C08G85/00 , C08L71/02 , A61K31/765 , C08G65/32
CPC分类号： A61K9/1075 , A61K9/5153 , C08G63/664 , C08G63/676 , C08G63/912 , C08G65/2627 , C08G65/329 , C08G85/00 , C08L71/02
摘要： The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on .alpha.-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on .omega.-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.
摘要翻译： PCT No.PCT / JP96 / 02200 Sec。 371日期：1998年2月5日 102（e）日期1998年2月5日PCT提交1996年8月5日PCT公布。 出版物WO97 / 06202 日期1997年2月20日本发明提供了在其两端具有官能团并且包含亲水/疏水链段的嵌段聚合物。 对于其两端的官能团，嵌段聚合物在α-末端具有氨基，羧基或巯基，在ω-末端具有羟基，羧基，醛基或乙烯基。 亲水链段包括聚环氧乙烷，而疏水链段来自丙交酯，内酯或（甲基）丙烯酸酯。 本发明的嵌段聚合物形成可用作生物相容性材料的聚合胶束。
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公开(公告)号：US5449513A
公开(公告)日：1995-09-12
申请号：US105535
申请日：1993-08-11
CPC分类号： C08G69/10 , A61K9/1075 , Y10T428/2985 , Y10T428/2989
摘要： The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.
摘要翻译： 本发明涉及由具有亲水和疏水性片段的嵌段共聚物组成的药物载体，包含通过所述药物载体中的物理治疗而被捕获的疏水性药物的聚合物胶束型药物和用于在药物载体中捕获疏水性药物的方法。 由根据本发明的嵌段共聚物组成的药物载体形成稳定的聚合胶束结构，通过物理捕获可以非常有效地引入疏水性药物。 发现即使在血清存在下，掺入的药物稳定地保持在胶束中。 此外，由于疏水性高的水溶性而难以施用于生物体的药物可以以聚合物胶束药物的形式施用。
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公开(公告)号：US5284766A
公开(公告)日：1994-02-08
申请号：US817954
申请日：1992-01-07
申请人： Teruo Okano , Kazunori Kataoka , Noriko Yamada , Yasuhisa Sakurai , Takayuki Amiya , Akira Mamada
发明人： Teruo Okano , Kazunori Kataoka , Noriko Yamada , Yasuhisa Sakurai , Takayuki Amiya , Akira Mamada
CPC分类号： C12N5/0068 , C12N2533/30
摘要： Disclosed is a bed material whereby cultured or grown cells are collected or detached from the material without a proteolysis enzyme or chemical material. The bed material comprises a support and a coating thereon, wherein the coating is formed from a polymer or copolymer which has a critical solution temperature to water within the range of 0.degree. C. to 80.degree. C.
摘要翻译： 公开了一种床材料，其中培养的或生长的细胞在没有蛋白水解酶或化学材料的情况下从材料中收集或分离。 床料包括载体和其上的涂层，其中涂层由聚合物或共聚物形成，该聚合物或共聚物具有在0摄氏度至80摄氏度范围内的水的临界溶解温度。
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公开(公告)号：US08841138B2
公开(公告)日：2014-09-23
申请号：US10566159
申请日：2004-07-28
申请人： Yukio Nagasaki , Tadahito Takahashi , Kazunori Kataoka , Fumiko Aboshi , Miki Kato , Tomoko Jomura , Hiroshi Kobayashi , Yoshinori Katsuyama , Masami Nakamae
发明人： Yukio Nagasaki , Tadahito Takahashi , Kazunori Kataoka , Fumiko Aboshi , Miki Kato , Tomoko Jomura , Hiroshi Kobayashi , Yoshinori Katsuyama , Masami Nakamae
IPC分类号： G01N33/553 , C12M1/40 , G01N33/543
CPC分类号： C12Q1/6837 , C12Q1/6834 , G01N27/327 , G01N27/3271 , G01N33/543 , G01N33/54366 , G01N33/54393
摘要： A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.
摘要翻译： 固定有检测分析物或分析物本身的物质的底物表面，该表面是通过用含有基于聚乙二醇链段的未交联聚合物的液体处理基材表面而形成的，所述处理同时进行 所述物质或分析物的固定或所述物质或分析物已被固定在所述表面上之后。 在用于测定的样品中共存的杂质蛋白等的非特异性吸附被显着抑制。
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公开(公告)号：US08592385B2
公开(公告)日：2013-11-26
申请号：US12281124
申请日：2006-09-04
申请人： Kazunori Kataoka , Yuichi Yamasaki , Seiji Takae
发明人： Kazunori Kataoka , Yuichi Yamasaki , Seiji Takae
IPC分类号： C12N15/85
CPC分类号： C08G73/0226 , A61K9/5146 , A61K48/00 , C12N15/87 , C12N15/88
摘要： It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a disulfide group and a nucleic acid.
摘要翻译： 本发明的目的是提供一种用作非病毒基因载体的聚离子络合物，其能够对靶细胞获得足够高的基因表达效率。 本发明的聚离子络合物包含通过二硫键和核酸将聚乙二醇与聚阳离子结合形成的嵌段共聚物。
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公开(公告)号：US07695905B2
公开(公告)日：2010-04-13
申请号：US10362174
申请日：2001-08-20
IPC分类号： C12Q1/68
CPC分类号： C07D495/04 , C07K17/14 , C12N11/14 , C12N15/1013 , G01N33/5434 , G01N2333/255 , G01N2446/86
摘要： The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a method of detecting a nucleic acid, a separating agent, and a method of separating a biological substance using the same.
摘要翻译： 本发明涉及固定有至少一种选自生物素和抗生物素蛋白的物质的临界溶解温度较低的磁性微粒，以及将物质转化的方法，微生物的分离或浓缩方法，改性方法 变性蛋白质，检测核酸的方法，分离剂以及使用其分离生物物质的方法。
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公开(公告)号：US07674478B2
公开(公告)日：2010-03-09
申请号：US10653626
申请日：2003-09-02
IPC分类号： A61K9/133
CPC分类号： A61F2/14 , A61F2/16 , A61F2250/0056 , A61K9/0051 , A61K9/1075
摘要： The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
摘要翻译： 本发明涉及一种涂覆的生物医学装置，所述胶束具有亲水性外壳和疏水性内芯，或疏水性外壳和亲水性内芯，所述胶束由HLB值为约1至约 医疗装置可以在其上具有一个涂层或多个涂层。 本发明还涉及胶束作为药物载体的用途。
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公开(公告)号：US20090156782A1
公开(公告)日：2009-06-18
申请号：US11991282
申请日：2006-08-30
申请人： Kazunori Kataoka , Yuichi Yamasaki , Joon-Sik Park
发明人： Kazunori Kataoka , Yuichi Yamasaki , Joon-Sik Park
CPC分类号： C08G73/0233
摘要： The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator. Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
摘要翻译： 本发明提供由2-乙基-2-恶唑啉与2-异丙基-2-恶唑啉的单体混合物及其制备方法和通过使用特殊引发剂得到的2-异丙基-2-恶唑啉均聚物获得的大约单分散无规共聚物。 这种聚合物在宽温度范围内在水溶液中表现出温度响应性，并且是表面化学和生物材料技术领域中的有用材料。
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69.发明申请Cultured cell construct which contains spheroids of cultured animal cells and the use thereof 有权含有培养的动物细胞的球体的培养细胞构建体及其用途公开(公告)号：US20090011504A1
公开(公告)日：2009-01-08
申请号：US12230916
申请日：2008-09-08
IPC分类号： C12N5/06
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译： 将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。 因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。 该培养物保持长时间对实质细胞特异的功能。
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公开(公告)号：US07407840B2
公开(公告)日：2008-08-05
申请号：US11207347
申请日：2005-08-19
IPC分类号： H01L21/00
CPC分类号： H01L21/02675 , G02F1/13454 , G02F1/1368 , G02F2202/104 , H01L21/02532 , H01L21/0262 , H01L21/2022 , H01L21/2026 , H01L27/12 , H01L27/1285 , H01L29/04 , H01L29/66757 , H01L29/78609 , H01L29/78633 , H01L29/78675
摘要： A display device able to raise a light resistance of pixel transistors without depending upon a light shielding structure and a method of production of same, wherein an average crystal grain size of a polycrystalline silicon film 111 forming an active layer of the pixel transistors is controlled to be relatively small so as to suppress a photo-leakage current. The smaller the crystal grain size, the larger the included crystal defects. Carriers excited by light irradiation are smoothly captured by a defect level, and an increase of a photo-leakage current is suppressed. On the other hand, the average crystal grain size of the polycrystalline silicon film 111 constituting the peripheral transistors is controlled so as to become relatively large. The larger the crystal grain size, the larger the mobility of the carriers, and the higher the drivability of the peripheral transistors. This is because a higher speed operation is required for the peripheral transistors than the pixel transistors due to scanning of pixels and sampling of image signals.
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