摘要:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要:
A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
摘要:
A method of forming a capped die forms a cap wafer having a top side and a bottom side. The bottom side is formed with 1) a plurality of device cavities having a first depth, and 2) a plurality of second cavities that each have a greater depth than the first depth. At least some of the plurality of second cavities each generally circumscribe at least one of the device cavities. The method then secures the cap wafer to a device wafer in a manner that causes a plurality of the device cavities each to circumscribe at least one of circuitry and structure on the device wafer. Next, the method removes at least a portion of the top side of the cap wafer to expose the second cavities. This forms a plurality of caps that each protect the noted circuitry and structure.
摘要:
A three-dimensional display including a display panel and a phase retardation film is provided. The display panel has a plurality of first pixel regions and a plurality of second pixel regions arranged in arrays. The phase retardation film is configured on a surface of the display panel. Here, the phase retardation film has a plurality of first retardation regions and a plurality of second retardation regions that are arranged alternately. The first retardation regions have the same phase retardation, the second retardation regions have the same phase retardation, and the phase retardation of the first retardation regions is different from that of the second retardation regions. All the regions of the phase retardation film have the same optical transmittance. A displaying method adaptable to the three-dimensional display is also provided.
摘要:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要:
A dual backplate MEMS microphone system includes a flexible diaphragm sandwiched between two single-crystal silicon backplates. Such a MEMS microphone system may be formed by fabricating each backplate in a separate wafer, and then transferring one backplate from its wafer to the other wafer, to form two separate capacitors with the diaphragm.
摘要:
A method of forming a MEMS microphone forms circuitry and first MEMS microstructure on a first wafer in a first process, and second MEMS microstructure on a second wafer in a second process. The first process is thermally isolated from the second process. The method also layer transfers the second MEMS microstructure onto the first wafer. The first MEMS microstructure and second MEMS microstructure thus form a variable capacitor that communicates with the circuitry on the first wafer.
摘要:
Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
摘要:
There are provided compounds of the formula or a pharmaceutically acceptable salt or ester thereof wherein X, Y, W, W′, V, V′, V″, R1, R2 and R3 are as herein described.The compounds have utility as antiproliferative agents, especially, as anticancer agents.