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公开(公告)号:US20200255780A1
公开(公告)日:2020-08-13
申请号:US16863702
申请日:2020-04-30
Applicant: LIFE TECHNOLOGIES CORPORATION , Baxalta Incorporated , BAXALTA GMBH
Inventor: Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
Abstract: A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.
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公开(公告)号:US20200246740A1
公开(公告)日:2020-08-06
申请号:US16854358
申请日:2020-04-21
Applicant: Life Technologies Corporation
Inventor: Jason D. Brown , Clinton C. Staheli , Nephi D. Jones
IPC: B01D46/00 , C12M1/06 , B01F15/00 , B01F7/00 , B01F7/18 , B01F7/16 , C12M1/12 , B01F3/04 , C12M1/00
Abstract: A method for filtering a gas includes passing a gas into a compartment of a casing that includes a polymeric film, the casing having: a first sleeve having a first outlet opening, a first filter being at least partially disposed within the first sleeve so that gas passing through the first sleeve must pass through the first filter; and a second sleeve having an second outlet opening, a second filter being at least partially disposed within the second sleeve so that gas passing through the second sleeve must pass through the second filter, the second sleeve being closed so that the gas passing into the compartment of the casing passes through the first sleeve and the first filter and directly contacts at least a portion of the first sleeve comprised of the polymeric film but does not pass through the second sleeve. Opening the second sleeve when a predetermined condition is met so that the gas passes through the second sleeve and the second filter.
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公开(公告)号:US10519413B2
公开(公告)日:2019-12-31
申请号:US15916635
申请日:2018-03-09
Applicant: Life Technologies Corporation
Inventor: Christopher D. Brau , Nephi D. Jones , Benjamin R. Madsen , Michael E. Goodwin
IPC: C12M1/04 , C12M1/00 , B01F13/02 , B01F3/04 , C12M1/02 , C12M1/34 , B01F7/22 , B01F15/00 , C12M1/06 , B01F11/00
Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.
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公开(公告)号:US20190329192A1
公开(公告)日:2019-10-31
申请号:US16510438
申请日:2019-07-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Derik R. West
Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface. The bag has a bottom end wall that includes a first sparger and a second sparger. The first sparger and the second sparger each have a flexible first sheet overlying a flexible second sheet, the first sheet and the second sheet being secured together so as to form a sparging area bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the sparging area being gas permeable so that gas can pass from the sparging area, through the first sheet, and into the chamber.
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公开(公告)号:US20190001237A1
公开(公告)日:2019-01-03
申请号:US16067509
申请日:2016-12-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Scott P. Collins , Federico Carlos Rodriguez Peralta , Nephi D. Jones , Christopher D. Brau
Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.
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公开(公告)号:US10166306B2
公开(公告)日:2019-01-01
申请号:US15642015
申请日:2017-07-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Bradley H. Buchanan
Abstract: A container includes a first wall made of a polymeric material, a second wall made of a polymeric material, and a plurality of elongated baffles, spacers or seam lines formed between the first wall and the second wall to form a plurality of separate fluid flow paths. Each of the plurality of fluid flow paths are separated from the other fluid flow paths by at least one of the baffles, spacers or seam lines. Each of the plurality of fluid flow paths have a first end in fluid communication with an inlet and have a second end in fluid communication with an outlet.
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公开(公告)号:US10059916B2
公开(公告)日:2018-08-28
申请号:US15249781
申请日:2016-08-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Nephi D. Jones , Christopher D. Brau
CPC classification number: C12M29/20 , B01D5/00 , B01D19/0005 , B01D19/0031 , B01D19/0036 , B01D46/0002 , B01D46/002 , B01D46/446 , B01D53/265 , C12M23/14 , C12M23/26 , C12M29/04 , C12M29/06 , C12M41/14 , C12M41/40 , C12M41/48
Abstract: A method for filtering a gas includes delivering a gas into a compartment of a gas filter, the compartment being at least partially bounded by a casing comprised of a flexible sheet of polymeric film. A partial vacuum is applied to the gas filter so that the partial vacuum assists in drawing the gas through a porous filter body of the gas filter that is at least partially disposed within the compartment of the gas filter.
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公开(公告)号:US20180117546A1
公开(公告)日:2018-05-03
申请号:US15799580
申请日:2017-10-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jeffery C. Hurd , Nephi D. Jones , Jacob D. Lee
CPC classification number: B01F7/0095 , B01F3/0412 , B01F7/001 , B01F7/00341 , B01F7/00675 , B01F7/00691 , B01F7/007 , B01F7/00725 , B01F15/00006 , B01F15/0085 , B01F2003/04191 , B01F2215/0032 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/02 , C12M41/44
Abstract: A liquid mixing system includes a support housing at least partially bounding a compartment. A mount is secured to the support housing. A drive motor assembly is configured to engage a drive shaft for moving the drive shaft within the compartment of the support housing. A four bar linkage system extends between the mount and the drive motor assembly, the four bar linkage system being movable between a first position wherein the drive motor assembly is disposed at a first elevation and a second position wherein the drive motor assembly is disposed at a second elevation that is different from the first elevation.
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公开(公告)号:US09932553B2
公开(公告)日:2018-04-03
申请号:US15187258
申请日:2016-06-20
Applicant: Life Technologies Corporation
Inventor: Christopher D. Brau , Nephi D. Jones , Benjamin R. Madsen , Michael E. Goodwin
IPC: C12M1/00 , B01F13/02 , B01F3/04 , C12M1/02 , C12M1/34 , B01F7/22 , B01F15/00 , C12M1/06 , B01F11/00
CPC classification number: C12M29/06 , B01F3/04439 , B01F3/0446 , B01F3/04531 , B01F7/22 , B01F11/0002 , B01F11/0082 , B01F13/0205 , B01F13/0211 , B01F13/0272 , B01F15/0085 , B01F2003/04879 , B01F2003/04943 , B01F2215/0073 , C12M23/00 , C12M23/14 , C12M23/26 , C12M27/00 , C12M27/02 , C12M29/14 , C12M41/34
Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A first opening is formed on the container so as to communicate with the compartment. A liquid is disposed within the compartment and having a top surface disposed below the first opening. A gas is blown through the first opening so that the gas passes over at least a portion of the top surface of the liquid, the gas producing turbulence on the top surface of the liquid that is sufficient to produce a mass transfer between the gas and the liquid. A mixing element is disposed within the compartment.
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公开(公告)号:US20170296685A1
公开(公告)日:2017-10-19
申请号:US15642015
申请日:2017-07-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Bradley H. Buchanan
Abstract: A container includes a first wall made of a polymeric material, a second wall made of a polymeric material, and a plurality of elongated baffles, spacers or seam lines formed between the first wall and the second wall to form a plurality of separate fluid flow paths. Each of the plurality of fluid flow paths are separated from the other fluid flow paths by at least one of the baffles, spacers or seam lines. Each of the plurality of fluid flow paths have a first end in fluid communication with an inlet and have a second end in fluid communication with an outlet.
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