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公开(公告)号：US20170312751A1
公开(公告)日：2017-11-02
申请号：US15646578
申请日：2017-07-11
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
CPC classification number: B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US20170160281A1
公开(公告)日：2017-06-08
申请号：US15440136
申请日：2017-02-23
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko , Martin Stengelin
IPC: G01N33/574
CPC classification number: G01N33/57423 , A61K39/39533
Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20140315742A1
公开(公告)日：2014-10-23
申请号：US14348275
申请日：2012-09-28
Applicant: MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC: G01N33/566
CPC classification number: G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。
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公开(公告)号：US20140315189A1
公开(公告)日：2014-10-23
申请号：US14357653
申请日：2012-11-09
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , George Sigal
CPC classification number: C12Q1/70 , C12Q1/6813 , C12Q1/6834 , G01N33/542 , G01N33/54333 , C12Q2563/179
Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
Abstract translation: 本发明涉及降低多重免疫测定中使用的物种之间的交叉反应性的方法。
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公开(公告)号：US20140221368A1
公开(公告)日：2014-08-07
申请号：US14168629
申请日：2014-01-30
Applicant: Meso Scale Technologies, LLC
Inventor： Simone Barbero , Eli N. Glezer , Anu Mathew
IPC: G01N33/574 , A61K31/5377
CPC classification number: G01N33/57415 , A61K31/5377 , C12Q1/42 , C12Q1/485 , G01N2333/912 , G01N2333/916 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者乳腺癌的方法，以及监测乳腺癌进展的方法和/或监测治疗剂或治疗方案治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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Patent Agency Ranking
公开(公告)号：US20140191109A1
公开(公告)日：2014-07-10
申请号：US14147216
申请日：2014-01-03
Applicant: Meso Scale Technologies, LLC
Inventor： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D.T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
CPC classification number: G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
Abstract translation: 描述了用于进行测定的装置，系统，方法，试剂和试剂盒及其制备方法。 它们特别适用于以多孔板测定方式进行自动化分析。
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公开(公告)号：US12163954B2
公开(公告)日：2024-12-10
申请号：US17132380
申请日：2020-12-23
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin
IPC: C12Q1/6804 , G01N21/66 , G01N21/76 , G01N21/77 , G01N33/53 , G01N33/533 , G01N33/543 , G01N33/569 , G01N33/58
Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.
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公开(公告)号：US20240151726A1
公开(公告)日：2024-05-09
申请号：US18413155
申请日：2024-01-16
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Anu Mathew , Martin Stengelin , Mingyue Wang
IPC: G01N33/574
CPC classification number: G01N33/57438 , G01N2333/47 , G01N2333/4725 , G01N2333/70503 , G01N2400/00 , G01N2800/085 , G01N2800/56
Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US11951483B2
公开(公告)日：2024-04-09
申请号：US17215962
申请日：2021-03-29
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC: G01N33/543 , B01L3/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/68
CPC classification number: B01L3/50853 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/54306 , G01N33/54353 , G01N33/6845 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0829 , G01N2458/10 , C12Q1/6816 , C12Q2563/131
Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US11896978B2
公开(公告)日：2024-02-13
申请号：US17032524
申请日：2020-09-25
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
CPC classification number: B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/087 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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