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    Liposomes with enhanced entrapment capacity, method and use
    62.
    发明授权
    Liposomes with enhanced entrapment capacity, method and use 失效
    具有增强的捕获能力，方法和用途的脂质体

    公开(公告)号：US5702722A

    公开(公告)日：1997-12-30

    申请号：US527087

    申请日：1995-09-12

    申请人： Herve Tournier ,  Michel Schneider ,  Christian Guillot

    发明人： Herve Tournier ,  Michel Schneider ,  Christian Guillot

    IPC分类号： A61K9/127 ,  A61K49/04 ,  B01J13/02

    CPC分类号： A61K9/1277 ,  Y10S514/945 ,  Y10T428/2984

    摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.

    摘要翻译： 本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。 本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法 使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据 的方法。

    Process for the preparation of liposomes in aqueous solution
    65.
    发明授权
    Process for the preparation of liposomes in aqueous solution 失效
    在水溶液中制备脂质体的方法

    公开(公告)号：US4224179A

    公开(公告)日：1980-09-23

    申请号：US931242

    申请日：1978-08-04

    申请人： Michel Schneider

    发明人： Michel Schneider

    IPC分类号： B01J13/12 ,  A61K9/10 ,  A61K9/127 ,  A61K9/50 ,  B01J13/02

    CPC分类号： A61K9/1277 ,  Y10S516/929

    摘要： A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipophilic hydrophobic group to form a dispersion of liposome precursors in the solvent, the precursors consisting of small vesicles of the first aqueous liquid surrounded by a monomolecular film of compound XY, emulsifying the liposome precursors in a second aqueous medium in the presence of a compound of the formula ZW wherein Z is a hydrophilic group and W is a hydrophobic group to thereby form a solution or suspension of liposomes in the second aqueous medium, said liposomes consisting of the first aqueous liquid surrounded by a bimolecular film of the structure XY-WZ and removing the water-insoluble solvent prior to after said emulsification.

    摘要翻译： 一种用于制备脂质体在水性介质中的溶液或悬浮液的方法，包括以下步骤：在式XY化合物的存在下，将基本上不溶于水的溶剂中分散第一含水液体，其中X为亲水疏乳基团， Y是亲脂性疏水基团，以在溶剂中形成脂质体前体的分散体，前体由第一含水液体由化合物XY的单分子膜包围的第一含水液体组成，在第二种含水介质中，在第二种含水介质的存在下乳化脂质体前体 式ZW的化合物，其中Z是亲水基团，W是疏水基团，从而在第二水性介质中形成脂质体的溶液或悬浮液，所述脂质体由由结构XY的双分子膜包围的第一含水液体组成 -WZ，并在所述乳化之前除去水不溶性溶剂。

    Quantification analysis of immobilized contrast agent in medical imaging applications
    66.
    发明授权
    Quantification analysis of immobilized contrast agent in medical imaging applications 有权
    医学成像应用中固定化造影剂的定量分析

    公开(公告)号：US09072492B2

    公开(公告)日：2015-07-07

    申请号：US12811089

    申请日：2008-12-23

    申请人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    发明人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    IPC分类号： A61B8/14 ,  A61B8/08 ,  G06F19/12

    CPC分类号： A61B8/481 ,  A61B8/14 ,  A61B8/5223 ,  G06F19/12

    摘要： An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.

    摘要翻译： 一个实施方案分析患者的身体部分，该患者被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 对应系统的一个实施例提供一个回波信号，其指示随着时间的推移对身体部位的询问信号的响应，将回波信号与时间模型函数拟合，该时间模型函数对身体部位中造影剂的时间演化进行建模 时间模型功能包括对造影剂的循环进行建模的循环功能和对来自固定的造影剂的回波信号的衰减进行建模的衰减函数的组合，并估计造影剂的至少一个动力学指标 时间模型功能。

    Liposomal assembly for therapeutic and/or diagnostic use
    67.
    发明授权
    Liposomal assembly for therapeutic and/or diagnostic use 有权
    用于治疗和/或诊断用途的脂质体组装

    公开(公告)号：US07749485B2

    公开(公告)日：2010-07-06

    申请号：US11596447

    申请日：2005-05-31

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K51/00 ,  A61M36/14 ,  B32B5/16 ,  B01F3/00

    CPC分类号： A61K9/1075 ,  A61K9/1271 ,  A61K48/0091 ,  A61K49/1812 ,  C12N15/88 ,  Y10S977/907 ,  Y10T428/2982

    摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

    摘要翻译： 用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。 组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述 活性化合物可以连接到单个脂质体。 此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

    Gas- Filled Microvesicles Composition for Contrast Imaging
    68.
    发明申请
    Gas- Filled Microvesicles Composition for Contrast Imaging 有权
    气体填充的微泡组合物用于对比成像

    公开(公告)号：US20080008657A1

    公开(公告)日：2008-01-10

    申请号：US11660188

    申请日：2005-08-17

    申请人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    发明人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223

    摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less. The composition of the invention can be effectively employed at rather different ultrasound transmission frequencies differing by about 8 MHz.

    摘要翻译： 本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。 所述组合物优选包含至少两种气体填充微泡的不同制剂，其优选具有不同的平均尺寸。 特别地，所述制剂优选具有彼此不同的至少0.5μm，更优选至少1.0μm的相应的D V值。 或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。 根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10微米的微泡总数计算的，包含在直径为8微米或更小的微泡中。 本发明的组合物可以以不同于约8MHz的相当不同的超声波传播频率有效地使用。