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    OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING SYSTEMS HAVING ADAPTABLE LENS SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS
    61.
    发明申请
    OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING SYSTEMS HAVING ADAPTABLE LENS SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS 有权
    具有适应镜头系统的光学相干图像（OCT）成像系统及相关方法和计算机程序产品

    公开(公告)号：US20090268161A1

    公开(公告)日：2009-10-29

    申请号：US12429323

    申请日：2009-04-24

    申请人： Robert H. Hart ,  Eric L. Buckland ,  Glenn A. Myers ,  Joseph A. Izatt

    发明人： Robert H. Hart ,  Eric L. Buckland ,  Glenn A. Myers ,  Joseph A. Izatt

    IPC分类号： A61B3/15 ,  A61B3/14

    CPC分类号： A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G02B26/105

    摘要： OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

    摘要翻译： 提供OCT成像系统用于对球形眼睛进行成像，该眼球包括具有相关联的源臂路径的源和具有耦合到源路径的相关参考臂路径的参考臂。 参考臂路径具有相关联的参考臂路径长度。 还提供具有与源臂和参考臂路径相连的相关联的样本臂路径的样本。 具有针对球形眼的直径优化的聚焦功率的透镜与连接到参考臂的参考臂路径长度调节模块一起提供。 参考臂路径长度调节模块被配置为自动调整参考臂路径长度，使得参考臂路径长度基于被摄体的眼睛直径。

    Doppler flow imaging using optical coherence tomography
    64.
    发明授权
    Doppler flow imaging using optical coherence tomography 有权
    多普勒血流成像使用光学相干断层扫描

    公开(公告)号：US06735463B2

    公开(公告)日：2004-05-11

    申请号：US09468674

    申请日：1999-12-21

    申请人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

    发明人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

    IPC分类号： A61B502

    CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02045 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/60

    摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.

    摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

    Interferometers for optical coherence domain reflectometry and optical coherence tomography using nonreciprocal optical elements
    65.
    发明授权
    Interferometers for optical coherence domain reflectometry and optical coherence tomography using nonreciprocal optical elements 有权
    用于光学相干畴反射测量和使用非互易光学元件的光学相干断层扫描的干涉仪

    公开(公告)号：US06657727B1

    公开(公告)日：2003-12-02

    申请号：US09393761

    申请日：1999-09-10

    申请人： Joseph A. Izatt ,  Andrew M. Rollins

    发明人： Joseph A. Izatt ,  Andrew M. Rollins

    IPC分类号： G01B902

    CPC分类号： G01B9/02091 ,  G01B9/02022 ,  G01B2290/35 ,  G01B2290/70 ,  G01N21/4795

    摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.

    摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学 探测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

    Systems and Methods for Surgical Microscope and Optical Coherence Tomography (OCT) Imaging
    68.
    发明申请
    Systems and Methods for Surgical Microscope and Optical Coherence Tomography (OCT) Imaging 有权
    手术显微镜和光学相干断层扫描（OCT）成像系统和方法

    公开(公告)号：US20120092615A1

    公开(公告)日：2012-04-19

    申请号：US13010497

    申请日：2011-01-20

    申请人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

    发明人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

    IPC分类号： A61B3/14 ,  A61B3/12 ,  G01B9/02

    CPC分类号： G01B9/02091 ,  A61B3/102 ,  A61B3/13 ,  G01B9/0203

    摘要： A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective.

    摘要翻译： 手术显微镜组件包括显微镜主要目标和显微镜成像光学元件。 显微镜主要目标和显微镜成像光学器件定义了从样品通过显微镜主要目标和显微镜成像光学器件的观察光束路径。 组件包括具有照明光束和收集光束的光学相干断层摄影（OCT）单元和在显微镜主要物镜和显微镜成像光学器件之间的分束器。 分束器被配置为将来自显微镜主物镜的光的一部分引导到显微镜成像光学器件，并将来自显微镜主物镜的另一部分光引导到OCT单元收集光束。 分束器还被配置成将来自OCT单元的照明光束引导到显微镜主目标和样品。 光束形成单元位于OCT单元和分束器之间。 光束形成单元被配置为形成OCT单元的照明光束，以便大致对应于显微镜主要物镜的尺寸。