公开(公告)号：US09693716B2

公开(公告)日：2017-07-04

申请号：US13044119

申请日：2011-03-09

申请人： Robert Michael Ecker ,  Timothy J. Davis ,  James D. Reinke

发明人： Robert Michael Ecker ,  Timothy J. Davis ,  James D. Reinke

IPC分类号： A61B5/1455 ,  A61B5/046 ,  G01D5/34 ,  G01D18/00

CPC分类号： A61B5/14551 ,  A61B5/046 ,  A61B5/14552 ,  G01D5/34 ,  G01D18/008

摘要： A medical device including an optical sensor is configured to measure an optical signal by integrating a current induced on a light detector of the optical sensor to obtain a voltage signal. The voltage signal is compared to a threshold. Responsive to the voltage signal reaching the threshold, an optical sensor control parameter is adjusted. The optical sensor is operated to produce the voltage signal using the adjusted control parameter.

公开(公告)号：US08825170B2

公开(公告)日：2014-09-02

申请号：US12915832

申请日：2010-10-29

申请人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

发明人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

IPC分类号： A61N1/00 ,  A61N1/08 ,  A61N1/02 ,  G06F1/12 ,  A61N1/372

CPC分类号： A61N1/37264 ,  A61N1/025 ,  A61N1/08 ,  A61N1/372 ,  A61N1/37276 ,  G06F1/04 ,  G06F1/12

摘要： Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.

摘要翻译： 描述了各种技术，用于周期性地执行校准例程以基于也包括在IMD中的高精度参考时钟校准可植入医疗设备（IMD）内的低功率系统时钟。 系统时钟连续供电，参考时钟仅在校准程序中打开电源。 这些技术包括基于系统时钟的频率和固定数量的时钟周期上的参考时钟之间的差异来确定系统时钟的时钟误差，以及调整系统时钟的修整值以补偿时钟误差。 例如，用delta-sigma循环校准系统时钟可以减少时间误差。 这允许系统时钟的精确调整，以补偿由于调整分辨率，电路噪声和温度引起的误差。

公开(公告)号：US20120165902A1

公开(公告)日：2012-06-28

申请号：US13008524

申请日：2011-01-18

申请人： John Louis Sommer ,  Joseph Michael D'Sa ,  Joyce K. Yamamoto ,  Brad C. Tischendorf ,  James D. Reinke ,  Andrew J. Thom ,  Thomas P. Miltich ,  William John Taylor ,  Kenneth C. Gardeski ,  Larry Earl Tyler ,  Jeffrey O. York ,  Gordon O. Munns

发明人： John Louis Sommer ,  Joseph Michael D'Sa ,  Joyce K. Yamamoto ,  Brad C. Tischendorf ,  James D. Reinke ,  Andrew J. Thom ,  Thomas P. Miltich ,  William John Taylor ,  Kenneth C. Gardeski ,  Larry Earl Tyler ,  Jeffrey O. York ,  Gordon O. Munns

IPC分类号： A61N1/36

CPC分类号： A61N1/362 ,  A61N1/05 ,  A61N1/056 ,  A61N1/372

摘要： Hermetically sealed assemblies, for example, that include IC chips, are configured for incorporation within a connector terminal of an implantable medical electrical lead, preferably within a contact member of the terminal. An assembly may include two feedthrough subassemblies, welded to either end of the contact member, to form an hermetic capsule, in which an IC chip is enclosed, and a tubular member, which allows a lumen to extend therethrough, along a length of the terminal. A multi-electrode lead may include multiplexer circuitry, preferably a switch matrix element and a communications, control and power supply element that are electrically coupled to the contact member and to another contact member of the terminal. Each pair of switch matrix switches allows for any two of the electrodes to be selected, in order to deliver a stimulation vector, via stimulation pulses from a device/pulse generator, to which the connector terminal is connected.

摘要翻译： 例如，包括IC芯片的密封组件被配置为并入可植入医疗电线的连接器端子内，优选地在端子的接触构件内。 组件可以包括焊接到接触构件的任一端的两个馈通子组件，以形成封闭IC芯片的密封胶囊，以及允许内腔沿着端子的长度延伸穿过的管状构件 。 多电极引线可以包括多路复用器电路，优选地是开关矩阵元件和通信，控制和电源元件，其电耦合到接触构件和终端的另一接触构件。 每对开关矩阵开关允许选择任何两个电极，以便通过连接器端子连接到的装置/脉冲发生器的刺激脉冲传送刺激矢量。

公开(公告)号：US20100185262A1

公开(公告)日：2010-07-22

申请号：US12690957

申请日：2010-01-21

申请人： Jonathan L. Kuhn ,  Jonathan P. Roberts ,  Andrew J. Ries ,  James D. Reinke ,  Jeffrey M. Jelen ,  Robert M. Ecker ,  Timothy J. Davis ,  Can Cinbis ,  Thomas A. Anderson

发明人： Jonathan L. Kuhn ,  Jonathan P. Roberts ,  Andrew J. Ries ,  James D. Reinke ,  Jeffrey M. Jelen ,  Robert M. Ecker ,  Timothy J. Davis ,  Can Cinbis ,  Thomas A. Anderson

IPC分类号： A61N1/08 ,  A61B5/00

CPC分类号： A61B5/1459 ,  A61B5/14542 ,  A61B5/1495 ,  A61B2562/0233 ,  A61B2562/046 ,  A61N1/36557 ,  G06F19/00 ,  G16H40/63

摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test

摘要翻译： 具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。 每个组件设置有至少一个发光装置和至少一个光检测装置。 耦合到光学传感器的设备控制器控制每个组件的功能。 控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。 响应于性能测试的结果，控制器选择多个光学传感器组件中的至少另一个作为光检测组件进行操作

公开(公告)号：US20090270953A1

公开(公告)日：2009-10-29

申请号：US12107921

申请日：2008-04-23

申请人： Robert M. Ecker ,  Jonathan L. Kuhn ,  James D. Reinke ,  Can Cinbis ,  Timothy J. Davis ,  Paul F. Gerrish ,  Jonathan P. Roberts

发明人： Robert M. Ecker ,  Jonathan L. Kuhn ,  James D. Reinke ,  Can Cinbis ,  Timothy J. Davis ,  Paul F. Gerrish ,  Jonathan P. Roberts

IPC分类号： A61N5/06 ,  H01L31/12

CPC分类号： A61B5/0086 ,  A61B2562/028 ,  A61N1/3621 ,  A61N1/36557 ,  A61N1/375 ,  A61N1/3956

摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.

摘要翻译： 反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。 在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。 发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。 光学传感器可以使用微机电系统（MEMS）制造技术来制造。

公开(公告)号：US20090118808A1

公开(公告)日：2009-05-07

申请号：US12350382

申请日：2009-01-08

申请人： Hugo A. Belacazar ,  James D. Reinke ,  Robert M. Ecker

发明人： Hugo A. Belacazar ,  James D. Reinke ,  Robert M. Ecker

IPC分类号： A61N1/05

CPC分类号： A61N1/36514 ,  A61B5/02055 ,  A61B5/145 ,  A61B5/14532 ,  A61N1/05 ,  A61N1/056

摘要： An implantable medical lead includes a device, such as a physiological sensor, that is coupled to one or more stimulation/sensing sensing conductors within the lead. When the implantable medical lead is coupled to an implantable medical device, the device carried by the lead both receives power from, and communicates with the implantable medical device via the one or more stimulation/sensing sensing conductors. Each of the one or more stimulation/sensing sensing conductors is also coupled to an electrode that is exposed to body tissue.

摘要翻译： 可植入医疗引线包括耦合到引线内的一个或多个刺激/感测感测导体的装置，例如生理传感器。 当可植入医疗引线连接到可植入医疗设备时，由引线承载的设备都经由一个或多个刺激/感测感测导体从可植入医疗设备接收电力并与可植入医疗设备进行通信。 一个或多个刺激/感测感测导体中的每一个还耦合到暴露于身体组织的电极。

公开(公告)号：US06985775B2

公开(公告)日：2006-01-10

申请号：US10059601

申请日：2002-01-29

申请人： James D. Reinke ,  Jeffrey D. Wilkinson ,  Ron Kalin ,  Laurie D. Foerster ,  Volkert A. Zeijlemaker

发明人： James D. Reinke ,  Jeffrey D. Wilkinson ,  Ron Kalin ,  Laurie D. Foerster ,  Volkert A. Zeijlemaker

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/086 ,  A61N1/3718

摘要： An electrical lead end cap includes a body defining a bore therein capable of receiving and retaining an end of an electrical lead and a connector capable of electrically coupling conductors leading to at least two electrodes. A method includes routing an electrical current induced in an electrical lead conductor disposed within body tissue to a plurality of electrodes, electrically coupled with the body tissue, via a circuit within an end cap attached to the electrical lead.

公开(公告)号：US06522915B1

公开(公告)日：2003-02-18

申请号：US09697438

申请日：2000-10-26

申请人： Thomas I. Ceballos ,  John E. Nicholson ,  Eric J. Panken ,  James D. Reinke ,  James Strom ,  Kevin K. Tidemand

发明人： Thomas I. Ceballos ,  John E. Nicholson ,  Eric J. Panken ,  James D. Reinke ,  James Strom ,  Kevin K. Tidemand

IPC分类号： A61B5042

CPC分类号： A61B5/6852 ,  A61B5/0422 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/164 ,  A61N1/375

摘要： The invention discloses a subcutaneous electrode array or SEA for use in medical devices. The arrangement provides an enhanced capability for detecting and gathering electrical cardiac signals via the array of relatively closely spaced subcutaneous electrodes. Further, switching circuits, signal processors and memory to process electric cardiac signals are implemented to enable a leadless orientation-insensitive SEA scheme for receiving the electrical signal from the heart. The SEA is distributed over the perimeter of the implanted medical device and includes a non-conductive surround shroud of biocompatible material. The surround shroud is placed around the periphery of the case of the implanted medical device. Various configurations of recesses, each of which contain individual electrodes, are implemented to provide an enhanced signal to noise ratio for improved signal quality.

摘要翻译： 本发明公开了一种用于医疗器械的皮下电极阵列或SEA。 该装置提供了通过相对紧密间隔的皮下电极阵列检测和收集电心电信号的增强功能。 此外，实现开关电路，信号处理器和用于处理电心脏信号的存储器，以实现用于从心脏接收电信号的无引导取向不敏感的SEA方案。 SEA分布在植入的医疗装置的周边上，并且包括生物相容性材料的非导电环绕护罩。 环绕护罩放置在植入医疗装置的壳体的周围。 实现各种构造的凹槽，其中每个包含单独的电极，以提供增强的信噪比，以改善信号质量。

公开(公告)号：US06496715B1

公开(公告)日：2002-12-17

申请号：US09718689

申请日：2000-11-22

申请人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

发明人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

IPC分类号： A61B504

CPC分类号： A61N1/375

摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.

摘要翻译： 一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。 根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。 一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。 然后可以将该位置和取向用作植入相应装置的位置和取向。

公开(公告)号：US5897577A

公开(公告)日：1999-04-27

申请号：US965801

申请日：1997-11-07

申请人： Can Cinbis ,  James D. Reinke ,  Todd M. Tanji

发明人： Can Cinbis ,  James D. Reinke ,  Todd M. Tanji

IPC分类号： A61N1/37

CPC分类号： A61N1/3706

摘要： A circuit for determining lead impedance during the time a pacing or other stimulating electrical pulse is being delivered measures current and voltage simultaneously to check for open circuits or short circuits based on different thresholds. The detection of a bad lead can force a double pulse to be delivered in real time in a unipolar configuration. Switching from unipolar to bipolar configuration based on detecting a bad bipolar circuit can be supported.

摘要翻译： 用于在起搏或其它刺激电脉冲输送期间确定引线阻抗的电路同时测量电流和电压，以根据不同的阈值检查开路或短路。 不良引线的检测可以强制双脉冲在单极配置下实时传输。 可以支持基于检测不良双极电路从单极性转换为双极配置。