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61.发明授权公开(公告)号：US07235576B1
公开(公告)日：2007-06-26
申请号：US10042203
申请日：2002-01-11
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号： A61K31/17 , A61K31/44 , C07D213/30 , C07C275/18 , C07C275/34
CPC分类号： C07D209/48 , C07D213/75 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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62.发明申请Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders 失效用于治疗高增殖性疾病的取代的四氢苯并噻吩并嘧啶胺化合物公开(公告)号：US20060293322A1
公开(公告)日：2006-12-28
申请号：US10557090
申请日：2004-07-23
申请人： Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
发明人： Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
IPC分类号： A61K31/5377 , A61K31/519 , C07D498/02
CPC分类号： C07D495/04 , C07D498/02
摘要： The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译： 本发明涉及式（I）化合物及其在治疗高增殖性疾病中的用途。
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63.发明申请公开(公告)号：US20060142295A1
公开(公告)日：2006-06-29
申请号：US10546091
申请日：2004-03-05
IPC分类号： A61K31/506 , A61K31/496 , A61K31/497
CPC分类号： A61K31/497 , A61K31/496 , A61K31/506
摘要： This invention relates to a method of treating a hyper-proliferative disorder comprising the administration of an effective amount of a compound of Formula (I) to a patient in need thereof.
摘要翻译： 本发明涉及一种治疗高增殖病症的方法，包括向有需要的患者施用有效量的式（I）化合物。
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64.发明申请2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US20050215594A1
公开(公告)日：2005-09-29
申请号：US11117759
申请日：2005-04-28
申请人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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公开(公告)号：US20050209261A1
公开(公告)日：2005-09-22
申请号：US11111704
申请日：2005-04-22
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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66.发明授权2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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67.发明申请Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号：US20050139814A1
公开(公告)日：2005-06-30
申请号：US10501689
申请日：2003-02-21
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号： A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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68.发明申请Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions 有权氟取代的ω-羧基芳基二苯脲用于治疗和预防疾病和病症公开(公告)号：US20050038080A1
公开(公告)日：2005-02-17
申请号：US10895985
申请日：2004-07-22
申请人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
发明人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
IPC分类号： A61K31/44 , A61K31/4415 , A61K31/675 , A61P35/00 , C07D213/78 , C07D213/81
CPC分类号： A61K31/4412 , C07D213/62 , C07D213/81
摘要： A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.
摘要翻译： 式（I）的化合物：其盐，其前药，其代谢物，含有这种化合物的药物组合物，以及这些化合物和组合物用于治疗由raf，VEGFR，PDGFR，p38和flt-3介导的疾病的用途。
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69.发明申请2-Oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效可用于治疗高增殖性，血管生成和炎性疾病的2-氧代-1,3,5-全氢三氮杂衍生物公开(公告)号：US20050032798A1
公开(公告)日：2005-02-10
申请号：US10788405
申请日：2004-03-01
申请人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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公开(公告)号：US06569810B1
公开(公告)日：2003-05-27
申请号：US10245431
申请日：2002-09-17
申请人： Reiner Fischer , Michael Ruther , Alan Graff , Arno Widdig , Jacques Dumas , Christoph Erdelen , Peter Dahmen , Markus Dollinger , Ulrike Wachendorff-Neumann
发明人： Reiner Fischer , Michael Ruther , Alan Graff , Arno Widdig , Jacques Dumas , Christoph Erdelen , Peter Dahmen , Markus Dollinger , Ulrike Wachendorff-Neumann
IPC分类号： A01N4328
CPC分类号： C07D317/72 , A01N35/06 , C07C45/455 , C07C49/697 , C07C49/747 , C07C49/753 , C07C62/26 , C07C69/013 , C07C69/757 , C07C69/96 , C07C309/66 , C07C2601/14 , C07C2602/24 , C07D317/08
摘要： The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I) to a process for their preparation and to their use as pesticides and herbicides.
摘要翻译： 本发明涉及式（I）的新型双环环戊烷-1,3-二酮衍生物，其用于制备和用作农药和除草剂的方法。
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