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    Human chemokine beta-9
    63.
    发明申请
    Human chemokine beta-9 失效
    人趋化因子β-9

    公开(公告)号：US20060040313A1

    公开(公告)日：2006-02-23

    申请号：US11260166

    申请日：2005-10-28

    申请人： Haodong Li ,  Mark Adams

    发明人： Haodong Li ,  Mark Adams

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/04 ,  C07K14/52

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Antibodies to human CK&bgr;-10/MCP-4
    66.
    发明授权
    Antibodies to human CK&bgr;-10/MCP-4 失效
    人类CKbeta-10 / MCP-4的抗体

    公开(公告)号：US06673344B1

    公开(公告)日：2004-01-06

    申请号：US09717209

    申请日：2000-11-22

    申请人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

    发明人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

    IPC分类号： A61K39395

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Human chemokine &bgr;-9
    67.
    发明授权
    Human chemokine &bgr;-9 失效
    人趋化因子β-9

    公开(公告)号：US06518046B1

    公开(公告)日：2003-02-11

    申请号：US08793381

    申请日：1997-05-19

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： C12N1500

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： The present invention relates to Human Ck&bgr;-9 polypeptides and DNA (RNA) encoding such chemolcine polypeptides. Moreover, a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck&bgr;-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective disease, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck&bgr;-9 coding sequence and over-expression of the Ck&bgr;-9 protein.

    摘要翻译： 本发明涉及人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）。 此外，公开了通过重组技术生产这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4
    68.
    发明授权
    Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4 失效
    人类趋化因子，CKbeta4和CKbeta10 / MCP-4

    公开(公告)号：US06174995B1

    公开(公告)日：2001-01-16

    申请号：US08613822

    申请日：1996-02-23

    申请人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Applebaum

    发明人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Applebaum

    IPC分类号： C07K1452

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人类趋化因子多肽和编码这种趋化因子多肽的DNA /（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Polynucleotides encoding leukocyte adhesion inhibitor-1 (LAI-1)
    70.
    发明授权
    Polynucleotides encoding leukocyte adhesion inhibitor-1 (LAI-1) 失效
    编码白细胞粘附抑制因子-1（LAI-1）的多核苷酸

    公开(公告)号：US07332302B2

    公开(公告)日：2008-02-19

    申请号：US11247235

    申请日：2005-10-12

    申请人： Haodong Li ,  Brent L. Kreider

    发明人： Haodong Li ,  Brent L. Kreider

    IPC分类号： C12N5/10 ,  C12N15/19 ,  C12N15/62

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K14/523 ,  C07K14/5421 ,  Y02A50/473 ,  Y10S930/14

    摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1 (CKα1 or CKa-1), a well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

    摘要翻译： 公开了使用编码人趋化因子β-11（Ckβ-11）多肽和人白细胞粘附抑制剂-1（LAI-1）多肽（先前称为趋化因子α1（CKalpha1或CKA- 1），以及Ckβ-11和/或LAI-1多肽本身，载体，宿主细胞以及用于制备其的重组方法。