摘要:
Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
摘要:
A system for use in presenting media content includes a media server configured to provide media content and a media client configured to obtain the media content from the media server and to present the media content on a device. The media client is configured to generate a first code and to transmit information to the media server. The information identifies the media client and the information indicates that the media client is available for pairing. The media server is configured to reply to the information with a second code that corresponds to the first code in order to enable pairing between the media server and the media client.
摘要:
The present invention provides an optical switch including a loss element having a signal loss, and a rare earth doped gain element optically connected in series with the loss element. The rare earth doped gain element is operable to produce a signal gain. The signal gain and the signal loss are about equal. The present invention also provides a method of optical switching including optically connecting a loss element in series with a rare earth doped gain element and passing an optical signal through the loss element and the gain element. The loss element attenuates the optical signal by a first amount. The method further includes selectively applying an optical pump to the gain element to perform the switching, the gain element amplifying the optical signal by the first amount in response to the optical pump.
摘要:
A superior powder form of a metallic soap for enhancing the properties of an invert emulsion drilling fluid may be prepared by a dry process saponification reaction. The process includes mixing a source of metal cations with the product of a Diels-Alder reaction of dienophiles with fatty acids and/or resin acids and allowing the mixture to react. Heating the mixture increases the rate of reaction. The solid product is ground to form a powder. The properties of the drilling fluid that may be improved by adding the soap include filtration control, fluid loss control, emulsification and emulsion stability, and electrical stability.
摘要:
This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.
摘要:
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs, to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting (and thereby binding) of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.
摘要:
An ohmic contact in accordance with the invention includes a layer of p-type GaN-based material. A first layer of a group II-VI compound semiconductor is located adjacent to the layer of p-type GaN-based material. The ohmic contact further includes a metal layer that provides metal contact. A second layer of a different II-VI compound semiconductor is located adjacent to the metal layer.
摘要:
Edge-emitting LED light source, and method for fabricating an edge-emitting LED light source. The edge-emitting LED light source has a plurality of edge-emitting LEDs arranged in close proximity to one another to define an array of edge-emitting LEDs. Light beams separately emitted by each of the plurality of edge-emitting LEDs in the array together form a single light beam that has a generally two-dimensional cross-sectional shape, for example, a square or other rectangular shape, and an increased overall light flux.
摘要:
An improved interface between a host computer and a tape drive emulation system includes software interfaces for communicating control, configuration, and policy data and a hardware interface for providing redundancy and fan-out between the main controller and host channels.
摘要:
One or more task page dialogs are housed within a frame. Each task page includes a header region and a content region. The header region includes a title serving as a main instruction regarding what input is expected within the content region. The content region includes text and/or user interface controls as defined by an application program requesting creation of the task page. A task page may also contain a footer region having button controls for a user to indicate that he or she has completed the task page and/or to terminate the task (or series of tasks) with which the page is associated. An application program requests creation of a task page by calling a programming interface function. Included in the function call are references to data for each of one or more pages.