公开(公告)号：US08821606B2

公开(公告)日：2014-09-02

申请号：US13384676

申请日：2010-07-21

申请人： Masato Ujihashi ,  Toshiya Hirata ,  Kazuhiko Kitanaka ,  Naohide Unno ,  Hiroshi Sugiyama ,  Noriyuki Namba

发明人： Masato Ujihashi ,  Toshiya Hirata ,  Kazuhiko Kitanaka ,  Naohide Unno ,  Hiroshi Sugiyama ,  Noriyuki Namba

IPC分类号： B24D3/00 ,  B24D11/00 ,  B24D18/00 ,  C09K3/14 ,  B24D3/02 ,  C09C1/68 ,  B24D3/06

CPC分类号： B24D3/06 ,  B24B33/086 ,  B24D3/08 ,  B24D18/0009

摘要： A metal bonded grinding stone is manufactured by heating and pressurizing a material including abrasive grains, a cobalt, a tungsten disulfide and a copper tin alloy to obtain a sintered product, and rapid-cooling the sintered product.

摘要翻译： 通过对包括磨粒，钴，二硫化钨和铜锡合金的材料进行加热加压来制造金属粘结研磨石以获得烧结产品，并快速冷却烧结产品。

公开(公告)号：US07888516B2

公开(公告)日：2011-02-15

申请号：US11658475

申请日：2005-08-02

申请人： Noboru Fukuda ,  Takahiro Ueno ,  Hiroshi Sugiyama

发明人： Noboru Fukuda ,  Takahiro Ueno ,  Hiroshi Sugiyama

IPC分类号： C07D233/00

CPC分类号： C07D403/12

摘要： A TGF-β gene expression inhibitor containing a pyrrole-immidazole polyamide comprising an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a γ-aminobutyric acid unit which can be folded into an U-shaped conformation at the above-described γ-aminobutyric acid unit site in a minor groove of a double-stranded region (hereinafter referred to as the target region) containing a part or the whole of the following base sequence (SEQ ID NO: 2) corresponding to −450 to −310 of human transforming growth factor β1 (hereinafter also referred to as h TGF-β1) promoter and a strand complementary thereto and in which a Py/Im pair, an Im/Py pair and a PY/Py pair correspond respectively to a C-G base pair, a G-C base pair and an A-T base pair and a T-A base pair.

摘要翻译： 转化生长因子 含有N-甲基吡咯单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸单元的基因表达抑制剂，其可以折叠成 在上述γ-氨基丁酸单元位置的双链区（以下称为靶区）的小槽中的U型构象，其含有部分或全部以下碱基序列（SEQ ID NO： 2）对应于-450至-310的人转化生长因子＆bgr; 1（以下也称为h TGF-β1）启动子和与其互补的链，并且其中Py / Im对，Im / Py对 并且PY / Py对分别对应于CG碱基对，GC碱基对和AT碱基对和TA碱基对。

公开(公告)号：US07807844B2

公开(公告)日：2010-10-05

申请号：US10570159

申请日：2004-09-03

申请人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

发明人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

IPC分类号： C00D403/02 ,  C07D233/00 ,  C07D487/04 ,  C07D233/34

CPC分类号： C07D403/14

摘要： A TGF-β gene expression inhibitor containing a pyrrole-imidazole polyamide having N-methylimidazole unit (hereinafter also referred to as Py), N-methylimidazole unit (hereinafter also referred to as Im) and γ-aminobutyrate unit which can be holded into an U-shaped conformation at the γ-aminobutyrate unit in the minor groove in a double helix region (hereinafter referred to as the target region) containing a complementary chain corresponding to the sequence at the −557 to −536 in the base sequence of a human transforming growth factor β1 (hereinafter also referred to as hTGF-β1) promoter, either as a whole or a part thereof: TAAAGGAGAGCAATTCT-TACAG (SEQ ID NO: 1) wherein a Py/Im pair corresponds to a C-G base pair, an Im/Py pair corresponds to a G-C base pair, and Py/Py pairs correspond respectively to an A-A base pair and a T-A base pair.

摘要翻译： 转化生长因子 含有具有N-甲基咪唑单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸酯单元的基因表达抑制剂，其可以被保持为U形构象 在双螺旋区域（以下称为靶区域）的小沟槽中的γ-氨基丁酸酯单元中含有对应于人转化生长因子碱基序列中的-557至-536处的序列的互补链 ; 1（以下也称为hTGF-＆bgr; 1）启动子，其全部或部分：TAAAGGAGAGCAATTCT-TACAG（SEQ ID NO：1），其中Py / Im对对应于CG碱基对， / Py对对应于GC碱基对，Py / Py对分别对应于AA碱基对和TA碱基对。

公开(公告)号：US20090171097A1

公开(公告)日：2009-07-02

申请号：US12093651

申请日：2006-11-14

申请人： Hiroshi Sugiyama ,  Chikara Dohno ,  Noboru Fukuda

发明人： Hiroshi Sugiyama ,  Chikara Dohno ,  Noboru Fukuda

IPC分类号： C07D403/14

CPC分类号： C07D403/14 ,  C07D409/14

摘要： A synthesis method for pyrrole-imidazole polyamide is automated at a higher level and can produce a product with a high yield in a more stable manner. In a solid phase synthesis method, the automated synthesis of a polyimide can be promoted by using HCTU as a condensation-activator, the yield of a product can be increased by charging a monomer in a solid form, and a pyrrole-imidazole polyamide having any sequence can be synthesis by combining the synthesis method with a manual synthesis with an acid chloride.

摘要翻译： 吡咯 - 咪唑聚酰胺的合成方法在更高的水平上自动化，并且可以以更稳定的方式产生高产率的产物。 在固相合成方法中，通过使用HCTU作为缩合活化剂可以促进聚酰亚胺的自动合成，通过加入固体形式的单体可以提高产物的产率，并且可以使用具有任意形式的吡咯 - 咪唑聚酰胺 可以通过将合成方法与手性合成与酰氯组合来合成序列。

公开(公告)号：US07550581B2

公开(公告)日：2009-06-23

申请号：US10546107

申请日：2004-02-23

申请人： Hiroshi Sugiyama ,  Yan Xu ,  Reiko Ikeda

发明人： Hiroshi Sugiyama ,  Yan Xu ,  Reiko Ikeda

IPC分类号： C07H21/00 ,  C07H19/04

CPC分类号： C07H19/167

摘要： It is intended to provide a novel monomer unit by which Z type DNA can be more effectively stabilized, a reagent for integrating this monomer unit into an oligonucleotide, and a method of stabilizing Z type DNA by using the reagent. Namely, a guanosine derivative represented by the following general formula [1]: wherein R1 represents acyl; R2 represents lower alkyl; R3 represents tri-substituted silyloxy or tetrahedropyranyloxy; and R4 represents cyanoethyl or allyl; a reagent for stabilizing Z type DNA which contains the guanosine derivative; and a method of stabilizing Z type DNA by using the guanosine derivative. It is also intended to provide a method of transferring guanosine having lower alkyl at the 8-position into an oligonucleotide by using the guanosine derivative; and an oligonucleotide carrying guanosine having lower alkyl at the 8-position transferred thereinto.

摘要翻译： 旨在提供可以更有效地稳定Z型DNA的新单体单元，将该单体单元整合到寡核苷酸中的试剂，以及使用该试剂来稳定Z型DNA的方法。 即，由以下通式[1]表示的鸟苷衍生物：其中R1表示酰基; R2代表低级烷基; R3表示三取代的甲硅烷氧基或四氢吡喃氧基; R4代表氰基乙基或烯丙基; 用于稳定含有鸟苷衍生物的Z型DNA的试剂; 以及使用鸟苷衍生物稳定Z型DNA的方法。 还提供通过使用鸟苷衍生物将在8-位具有低级烷基的鸟苷转移到寡核苷酸中的方法; 和携带转移到其中的8-位具有低级烷基的鸟苷的寡核苷酸。

公开(公告)号：US07378237B2

公开(公告)日：2008-05-27

申请号：US10285030

申请日：2002-11-01

申请人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

发明人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

IPC分类号： C12Q1/68 ,  A61K49/00 ,  A61K31/70 ,  A61K39/395

CPC分类号： G01N33/5011

摘要： A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance containing DNA or RNA by using one or more chemical species represented by the following general formula (I) which are capable of recognizing a DNA base sequence; a kit therefor; and a plate to be used therein: B-L-A (I) wherein B represents a chemical structure containing an non-natural base capable of recognizing a DNA base sequence; A represents a chemical structure having an interaction with DNA; and L represents a linker whereby the chemical structures A and B can be linked together.

摘要翻译： 通过使用人造化学物质筛选片段A（化学物质A）对含有DNA或RNA的物质（例如细胞）的影响的方法。 即，通过使用能够识别DNA碱基序列的由以下通式（I）表示的一种或多种化学物质来检测或鉴定含有DNA或RNA的物质上的化学物质A的功能的方法; 一套工具; 和其中使用的板：B-L-A（I）其中B表示含有能够识别DNA碱基序列的非天然碱基的化学结构; A表示与DNA相互作用的化学结构; L表示连接物，化学结构A和B可以连接在一起。

公开(公告)号：US07312661B2

公开(公告)日：2007-12-25

申请号：US11204051

申请日：2005-08-16

申请人： Kaname Motoyoshi ,  Masahiko Inamori ,  Kazuhiko Ohhashi ,  Hiroshi Sugiyama

发明人： Kaname Motoyoshi ,  Masahiko Inamori ,  Kazuhiko Ohhashi ,  Hiroshi Sugiyama

IPC分类号： H03F3/04

CPC分类号： H03F1/302 ,  H03F1/30 ,  H03F3/04 ,  H03F3/211 ,  H03F3/3432

摘要： A bias current to be supplied to an amplification circuit 60 is drawn out of a collector of a transistor Q11 of a bias circuit 10. The drawn-out bias current is input to a base of a transistor Q13 via an attenuation filter F2 and is output from an emitter of the transistor Q13 in the state where the voltage thereof is reduced by a level corresponding to Vbe. The attenuation filter F2 is conducted in a DC manner, and attenuates a component of a frequency fH(=2ft−fr) defined by a transmission frequency ft and a receiving frequency fr of a radio frequency signal. The bias current output from the emitter of the transistor Q13 is supplied to the amplification circuit 60 via an attenuation filter F1. The attenuation filter F1 is conducted in a DC manner, and attenuates a component of a frequency fL(=|fr−ft|).

摘要翻译： 将要提供给放大电路60的偏置电流从偏置电路10的晶体管Q 11的集电极引出。 引出偏置电流经由衰减滤波器F 2输入到晶体管Q13的基极，并且在其电压降低到对应于Vbe的电平的状态下从晶体管Q 13的发射极输出。 衰减滤波器F 2以直流方式传导，并且衰减由射频信号的发送频率ft和接收频率fr定义的频率fH（= 2ft-fr）的分量。 从晶体管Q13的发射极输出的偏置电流通过衰减滤波器F 1被提供给放大电路60。 衰减滤波器F 1以直流方式传导，并衰减频率fL（= | fr-ft |）的分量。

公开(公告)号：US06736727B1

公开(公告)日：2004-05-18

申请号：US09716317

申请日：2000-11-21

申请人： Miwako Doi ,  Hiroshi Sugiyama

发明人： Miwako Doi ,  Hiroshi Sugiyama

IPC分类号： A63F1300

CPC分类号： A63F13/327 ,  A63F13/12 ,  A63F13/352 ,  A63F13/79 ,  A63F13/92 ,  A63F2300/204 ,  A63F2300/208 ,  A63F2300/405 ,  A63F2300/406 ,  A63F2300/513 ,  A63F2300/552 ,  A63F2300/5553

摘要： This service system includes a portable terminal for acquiring a game character to be distributed, and then, executing a game in collaboration with a processor main body, an external station for making communication with the portable terminal via a short distance wireless equipment, and a service server for distributing the game character to the external station. The portable terminal transmits to the external station the contents of a history information storage section for storing history information concerning a game and a game character depending on a user that possesses the portable terminal. The external station receives the history information transmitted from the portable terminal, and then transmits to the portable terminal the game character information transmitted by referring to the history.

摘要翻译： 该服务系统包括用于获取要分发的游戏角色的便携式终端，然后与处理器主体协作执行游戏，外部站，用于经由短距离无线设备与便携式终端进行通信，以及服务 用于将游戏角色分发给外部站的服务器。 便携式终端根据具有便携式终端的用户向外部站发送用于存储有关游戏的历史信息和游戏角色的历史信息存储部的内容。 外部站接收从便携式终端发送的历史信息，然后通过参考历史向便携式终端发送游戏角色信息。

公开(公告)号：US06665087B2

公开(公告)日：2003-12-16

申请号：US09829077

申请日：2001-04-10

申请人： Hiroyuki Maeda ,  Yuko Suga ,  Hiroshi Sugiyama ,  Akira Katayama ,  Akihiko Shimomura ,  Kazuhiro Nakajima

发明人： Hiroyuki Maeda ,  Yuko Suga ,  Hiroshi Sugiyama ,  Akira Katayama ,  Akihiko Shimomura ,  Kazuhiro Nakajima

IPC分类号： G06R1500

CPC分类号： H04N1/00297 ,  G06K15/00 ,  G06K2215/0011 ,  G06K2215/0014 ,  G06K2215/0071 ,  H04N1/00283

摘要： An output apparatus which produces the print output by saving in a first memory print data input via a two-way interface, and converting the print data into the print out information, comprising a second memory different from the first memory for saving the print data with a print ID number added which is input via the interface, a retrieving unit for retrieving corresponding print data of the second memory based on a print ID number input from the outside, and an output unit for outputting the retrieved print data converted into the print out information.

摘要翻译： 一种输出装置，其通过保存经由双向接口输入的第一存储器打印数据并将打印数据转换为打印输出信息来产生打印输出，该打印输出装置包括与第一存储器不同的第二存储器，用于保存打印数据， 经由接口输入的打印ID号码，基于从外部输入的打印ID号来检索第二存储器的相应打印数据的检索单元，以及用于输出被转换成打印输出的检索到的打印数据的输出单元 信息。

公开(公告)号：US06339746B1

公开(公告)日：2002-01-15

申请号：US09651095

申请日：2000-08-30

申请人： Hiroshi Sugiyama ,  Tamotsu Hasegawa ,  Miwako Doi

发明人： Hiroshi Sugiyama ,  Tamotsu Hasegawa ,  Miwako Doi

IPC分类号： G01C200

CPC分类号： G01C21/3644 ,  G08G1/005

摘要： A route guidance system for a pedestrian. An input unit inputs a departure point and a destination point of the pedestrian. A route data memory stores route data representing position and connection of each route comprising a road network. A route calculation unit calculates a route from the departure point to the destination point by referring to the route data in said route data memory. A landmark memory stores landmark data for the pedestrian's confirmation; a landmark represents a signpost of the departure point, the destination point, and the route. A landmark selection unit selects the landmark data corresponding to the route calculated by said route calculation unit from said landmark memory. A presentation unit presents a route guidance to the pedestrian using the calculated route and the selected landmark data.

摘要翻译： 行人路线引导系统。 输入单元输入行人的出发点和目的地点。 路线数据存储器存储表示包括道路网络的每个路线的位置和连接的路线数据。 路线计算单元通过参照所述路线数据存储器中的路线数据来计算从出发地点到目的地点的路线。 地标记忆存储行人确认的地标数据; 一个里程碑表示出发点，目的地点和路线的路标。 地标选择单元从所述地标存储器中选择与由所述路线计算单元计算出的路线对应的地标数据。 呈现单元使用所计算的路线和所选的地标数据向行人呈现路线引导。