公开(公告)号：US20090000959A1

公开(公告)日：2009-01-01

申请号：US12129423

申请日：2008-05-29

申请人： Benjamin J. Feldman ,  Yi Wang ,  Ting Chen ,  Lam Tran

发明人： Benjamin J. Feldman ,  Yi Wang ,  Ting Chen ,  Lam Tran

IPC分类号： G01N27/26 ,  G01N27/327

CPC分类号： C12Q1/006 ,  C12Q1/54

摘要： The present invention provides methods and apparatuses for analyte detection.

摘要翻译： 本发明提供了用于分析物检测的方法和装置。

公开(公告)号：US20080277293A1

公开(公告)日：2008-11-13

申请号：US12027819

申请日：2008-02-07

申请人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

发明人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

IPC分类号： G01N33/50

CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

公开(公告)号：US20080194990A1

公开(公告)日：2008-08-14

申请号：US12021027

申请日：2008-01-28

申请人： Adam Heller ,  Benjamin J. Feldman ,  James Say

发明人： Adam Heller ,  Benjamin J. Feldman ,  James Say

IPC分类号： A61B5/00

CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

摘要： An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 μL. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.

摘要翻译： 提供了一种集成的穿刺和测量装置，其包括设计用于确定体积小于约1μL的生物流体中分析物的量和/或浓度的传感器。 刺穿构件适于从患者的位置刺穿和缩回以使流体从其中流出，并且传感器被定位成与患者的位置相邻，以便接收从现场流动的流体以产生电信号 指示流体中分析物的浓度。 传感器由包括分析物响应酶和氧化还原介体的工作电极和对电极组成。 分析物监测器可操作地连接到传感器并适于测量由传感器产生的信号。 还提供了可选地使用集成的穿刺和测量装置的分析物测量方法。

公开(公告)号：US07299082B2

公开(公告)日：2007-11-20

申请号：US10975207

申请日：2004-10-27

申请人： Benjamin J. Feldman ,  Geoffrey V. McGarraugh

发明人： Benjamin J. Feldman ,  Geoffrey V. McGarraugh

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/0004 ,  A61B5/0024 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6898 ,  A61B5/7246 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475

摘要： The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.

摘要翻译： 本发明涉及一种用于校准分析物测量装置的方法，其用于评估体内或体外的测量部位体液中分析物的浓度。 该方法包括测量来自“脱手”校准位点的血液中分析物的浓度或校准浓度，并且基于该校准浓度校准分析物测量装置。 本发明还涉及一种用于测量身体中分析物浓度的装置，系统或试剂盒，该装置，系统或试剂盒使用校准装置，用于基于在来自“脱手指”的血液中测量的分析物浓度来调节在体液中测量的分析物浓度 “校准站点。

公开(公告)号：US09201034B2

公开(公告)日：2015-12-01

申请号：US13537983

申请日：2012-06-29

申请人： Glenn Martin ,  Yi Wang ,  Simon Tonks ,  Benjamin J. Feldman

发明人： Glenn Martin ,  Yi Wang ,  Simon Tonks ,  Benjamin J. Feldman

IPC分类号： G01R31/3187 ,  G01N27/00 ,  G01N27/04

CPC分类号： G01N27/3274 ,  G01N27/048 ,  G01N27/3272 ,  G01R35/005

摘要： Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

摘要翻译： 用于确定感测装置可用性的方法和装置，例如用于自我监测和护理点装置。 在一个实施例中，本发明涉及一种确定设备可用性的方法，包括以下步骤：提供包括第一电垫的设备; 第二电垫; 和与第一和第二电焊盘的至少一部分接触的湿度响应性聚合物层; 在第一和第二电焊盘上施加电势; 测量与湿度响应聚合物层相关的电性能; 以及确定与所述湿度响应聚合物层相关联的所测量的电性能是否超过与所述装置可用性相关联的湿度阈值水平。

公开(公告)号：US08808531B2

公开(公告)日：2014-08-19

申请号：US11035131

申请日：2005-01-13

申请人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

发明人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

IPC分类号： G01N27/327 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/15 ,  G01N33/543 ,  C12Q1/00

CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

摘要： A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. Various electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can be used to determine the analyte concentration. The sensor can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum.

摘要翻译： 设计用于确定体积小于约1μL的样品中分析物浓度的传感器。 传感器具有涂覆有氧化还原介体的工作电极，其用作分析物和电极之间的电子转移剂。 可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。 可以使用各种电化学检测方法，例如电流，伏安和电位技术来确定分析物浓度。 传感器可用于确定生物液体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。

公开(公告)号：US08728297B2

公开(公告)日：2014-05-20

申请号：US11279694

申请日：2006-04-13

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：US08419927B2

公开(公告)日：2013-04-16

申请号：US13312190

申请日：2011-12-06

申请人： Yi Wang ,  Benjamin J. Feldman ,  Jared L. Watkin

发明人： Yi Wang ,  Benjamin J. Feldman ,  Jared L. Watkin

IPC分类号： G01N27/327 ,  G01N27/30

CPC分类号： A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  G01N27/3272 ,  Y10T436/200833

摘要： In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.

摘要翻译： 提供体外分析物传感器和分析物测定方法。 实施例包括包括一对电极的传感器，用于监测样品的样品室的填充。

公开(公告)号：US08357276B2

公开(公告)日：2013-01-22

申请号：US12551316

申请日：2009-08-31

申请人： Yi Wang ,  Shridhara Alva Karinka ,  Benjamin J. Feldman

发明人： Yi Wang ,  Shridhara Alva Karinka ,  Benjamin J. Feldman

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  B32B37/12 ,  B32B37/14 ,  B32B37/18 ,  B32B38/0004 ,  B32B2535/00 ,  G01N27/327 ,  Y10T156/1052

摘要： The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same.

公开(公告)号：US20130002278A1

公开(公告)日：2013-01-03

申请号：US13537983

申请日：2012-06-29

申请人： Glenn Martin ,  Yi Wang ,  Simon Tonks ,  Benjamin J. Feldman

发明人： Glenn Martin ,  Yi Wang ,  Simon Tonks ,  Benjamin J. Feldman

IPC分类号： G01R31/3187 ,  G01N27/00

CPC分类号： G01N27/3274 ,  G01N27/048 ,  G01N27/3272 ,  G01R35/005

摘要： Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

摘要翻译： 用于确定感测装置可用性的方法和装置，例如用于自我监测和护理点装置。 在一个实施例中，本发明涉及一种确定设备可用性的方法，包括以下步骤：提供包括第一电垫的设备; 第二电垫; 和与第一和第二电焊盘的至少一部分接触的湿度响应性聚合物层; 在第一和第二电焊盘上施加电势; 测量与湿度响应聚合物层相关的电性能; 以及确定与所述湿度响应聚合物层相关联的所测量的电性能是否超过与所述装置可用性相关联的湿度阈值水平。