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99 条记录 (耗时 0.025 秒)

    Small volume in vitro analyte sensor
    65.
    发明申请
    Small volume in vitro analyte sensor 有权
    体积小体积分析物传感器

    公开(公告)号：US20050164322A1

    公开(公告)日：2005-07-28

    申请号：US11035131

    申请日：2005-01-13

    申请人： Adam Heller ,  Benjamin Feldman ,  James Say ,  Mark Vreeke

    发明人： Adam Heller ,  Benjamin Feldman ,  James Say ,  Mark Vreeke

    IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  C12M1/34 ,  C12Q1/00 ,  G01N21/76 ,  G01N21/78 ,  G01N27/28 ,  G01N27/327 ,  G01N27/42 ,  G01N27/49 ,  G01N33/487 ,  G01N33/543 ,  G01N33/66 ,  C12Q1/54

    CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

    摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

    摘要翻译： 设计用于确定样品中分析物的量和浓度小于约1μl的传感器。 该传感器具有涂覆有不可浸出的氧化还原介体的工作电极。 氧化还原介体作为分析物和电极之间的电子转移剂。 此外，可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。 氧化还原介体通常是与聚合物结合的氧化还原化合物。 优选的氧化还原介体是可空气氧化的。 分析物的量可以通过库仑法测定。 一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。 通过该电流流向或来自分析物的电荷与样品中分析物的量相关。 还可以使用其他电化学检测方法，例如电流，伏安和电位技术。 本发明可用于测定生物液体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。 提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

    Electrodes with multilayer membranes and methods of using and making the electrodes
    66.
    发明申请
    Electrodes with multilayer membranes and methods of using and making the electrodes 有权
    具有多层膜的电极和使用和制造电极的方法

    公开(公告)号：US20040219664A1

    公开(公告)日：2004-11-04

    申请号：US10862932

    申请日：2004-06-07

    申请人： TheraSense, Inc.

    发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

    IPC分类号： C12M001/34

    CPC分类号： G01N27/3271

    摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

    摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

    Small volume in vitro analyte sensor
    68.
    发明申请
    Small volume in vitro analyte sensor 有权
    体积小体积分析物传感器

    公开(公告)号：US20040054267A1

    公开(公告)日：2004-03-18

    申请号：US10663153

    申请日：2003-09-15

    申请人： TheraSense, Inc.

    发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

    IPC分类号： A61B005/00

    CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

    摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

    摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

    Biological fuel cell and methods
    69.
    发明申请
    Biological fuel cell and methods 有权

    公开(公告)号：US20030152823A1

    公开(公告)日：2003-08-14

    申请号：US10385069

    申请日：2003-03-10

    申请人： TheraSense, Inc.

    发明人： Adam Heller

    IPC分类号： H01M004/90

    CPC分类号： H01M8/16 ,  H01M4/9008 ,  H01M2250/30 ,  Y02B90/18 ,  Y02E60/527

    摘要： A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.

    Biosensor
    70.
    发明申请
    Biosensor 有权
    生物传感器

    公开(公告)号：US20030102213A1

    公开(公告)日：2003-06-05

    申请号：US10303084

    申请日：2002-11-25

    申请人： TheraSense, Inc.

    发明人： Masao Gotoh ,  Hiroki Mure ,  Hiroshi Shirakawa

    IPC分类号： G01N027/26

    CPC分类号： C12Q1/005 ,  G01N27/3272 ,  Y10S435/817

    摘要： A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate.

    摘要翻译： 生物传感器包括用于吸取和容纳由两个上板和下板形成的样品的空间部分，两个板通过粘合剂层粘合在一起，用于吸收和容纳样品的空间部分被构造成在 周边部分，并由粘合剂层部分封闭，并且具有至少固定有葡萄糖氧化酶的工作电极和在该板的同一平面上的对电极。