公开(公告)号：US20170224756A1

公开(公告)日：2017-08-10

申请号：US15423280

申请日：2017-02-02

申请人： MERIAL INC.

发明人： Alphons Rutten ,  Caroline Pommellet ,  Pierre Chicoteau

IPC分类号： A61K36/87 ,  A61K9/00 ,  A61K47/02 ,  A23K20/10 ,  A61K39/215 ,  A61K39/12 ,  C12N7/00 ,  A23K20/20 ,  A61K33/04 ,  A61K47/12

CPC分类号： A61K36/87 ,  A23K10/37 ,  A23K20/10 ,  A23K20/20 ,  A23K20/22 ,  A23K20/30 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  A61K9/0007 ,  A61K9/0095 ,  A61K33/04 ,  A61K39/12 ,  A61K39/215 ,  A61K47/02 ,  A61K47/12 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10034 ,  C12N2770/20034 ,  Y02P60/877 ,  A61K2300/00

摘要： The present invention encompasses an effervescent Grape extract plus selenium composition which improves stress response. The invention also encompasses methods of improving stress response, such as stress response to vaccination or weaning, by administration of the composition. The invention also encompasses methods of producing meat with improved quality by raising an animal on a diet supplemented with an effervescent Grape extract plus selenium composition.

公开(公告)号：US20170196907A1

公开(公告)日：2017-07-13

申请号：US15472537

申请日：2017-03-29

申请人： Gambro Lundia AB

发明人： Anna Bryland ,  Ola Carlsson ,  Karin Sandin

IPC分类号： A61K33/04 ,  A61K31/194 ,  A61M1/28 ,  A61K33/30 ,  A61K33/42 ,  A61M1/16 ,  A61K33/00 ,  A61K33/24

CPC分类号： A61K33/04 ,  A61K31/194 ,  A61K33/00 ,  A61K33/08 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61M1/1654 ,  A61M1/287 ,  A61K2300/00

摘要： A replacement fluid for dialysis treatment includes selenium in a concentration of 0.6-1.8 μM, and rubidium in a concentration of 1.4-4.2 μM. The replacement fluid is essentially free of one or more of the trace elements selected from chromium, manganese, and copper.

公开(公告)号：US20170182169A1

公开(公告)日：2017-06-29

申请号：US15456028

申请日：2017-03-10

申请人： MSM Innovations, Inc.

发明人： Steven Gorelick ,  Michael Schiffman ,  Melody Olmstead ,  Adam Gorelick

IPC分类号： A61K47/42 ,  A61K33/42 ,  A61K47/10 ,  A61K33/04 ,  A61K9/08 ,  A61K9/00 ,  A61K33/14

CPC分类号： A61K47/42 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K33/04 ,  A61K33/14 ,  A61K33/42 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/34

摘要： The present invention provides methods for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic procedure. The methods can improve patient compliance, and thus, efficacy of the preparation. Specifically, the present methods make the gastrointestinal tract preparation composition palatable for the patient to consume. For example, for a patient preparing to undergo colonoscopy, the present methods make the bowel preparation solution taste significantly less salty.

公开(公告)号：US20170182090A1

公开(公告)日：2017-06-29

申请号：US15456497

申请日：2017-03-11

申请人： Braintree Laboratories, Inc.

发明人： Mark vB Cleveland ,  John S. Fordtran ,  Edmund V. Dennett

IPC分类号： A61K33/04 ,  A61K9/00

CPC分类号： A61K33/04 ,  A61K9/0095 ,  A61K2300/00

摘要： The present invention is generally directed to an oral pharmaceutical composition comprising a sulfate salt, for example, sodium sulfate and/or potassium sulfate, wherein the composition is substantially free of magnesium sulfate. The present invention is further directed to use of such oral pharmaceutical compositions to induce laxation or to treat or prevent constipation, e.g., opioid-induced constipation.

公开(公告)号：US20170182089A1

公开(公告)日：2017-06-29

申请号：US15284950

申请日：2016-10-04

申请人： Oregon Health & Science University ,  Government of The United States of America, d/b/a The Department of Veterans Affairs

发明人： Edward A. Neuwelt ,  Leslie Muldoon ,  Michael A. Pagel

IPC分类号： A61K33/04 ,  A61K9/00 ,  A61K33/24 ,  A61K31/282

CPC分类号： A61K33/04 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/195 ,  A61K31/198 ,  A61K31/282 ,  A61K31/661 ,  A61K33/24 ,  A61K38/063 ,  Y10S514/922 ,  A61K2300/00

摘要： A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.

公开(公告)号：US20170181971A1

公开(公告)日：2017-06-29

申请号：US15455488

申请日：2017-03-10

申请人： Northeastern University

发明人： Benjamin Geilich ,  Thomas Webster

IPC分类号： A61K9/127 ,  A61K9/51 ,  A61K31/43

CPC分类号： A61K9/1273 ,  A61K9/0019 ,  A61K9/5115 ,  A61K31/00 ,  A61K31/43 ,  A61K33/04 ,  A61K33/06 ,  A61K33/24 ,  A61K33/34 ,  A61K33/38

摘要： Provided are polymersomes for co-delivery of hydrophobic metallic nanoparticles and pharmaceutical agents and suspensions of such polymersomes. Also provided are methods of making such polymersomes and suspensions of polymersome and methods of using the same to treat diseases or conditions.

公开(公告)号：US09687545B2

公开(公告)日：2017-06-27

申请号：US14627235

申请日：2015-02-20

申请人： BARODON-S.F.CORP.

发明人： Soo-il Choi ,  Hyun Suk Choi ,  Yun Jeong Choi ,  Kyung Ae Hong ,  Byung Woo Yoo ,  Yong Ho Park ,  Sun Young Hwang ,  Jeong Hee Han ,  Chang Hoon Shin

IPC分类号： A61K33/06 ,  A61K33/10 ,  A61K33/14 ,  A61K39/39 ,  A23K1/16 ,  A61K39/12 ,  A61K33/00 ,  A61K31/695 ,  A61K33/04 ,  A23K20/22 ,  A23K50/10 ,  A23K50/30 ,  A23K50/80 ,  A61K39/00

CPC分类号： A61K39/39 ,  A23K20/22 ,  A23K50/10 ,  A23K50/30 ,  A23K50/80 ,  A61K31/695 ,  A61K33/00 ,  A61K33/04 ,  A61K33/14 ,  A61K39/12 ,  A61K2039/55505 ,  C12N2770/32134 ,  A61K2300/00

摘要： Disclosed are a nonspecific immunostimulant composition, a preparation method thereof, and uses thereof. The composition includes 150 to 300 wt. parts of sodium silicate, 2˜8 wt. parts of sodium thiosulfate, 0.5˜2 wt. parts of sodium carbonate, 0.5˜2 wt. parts of potassium chloride, 200˜400 wt. parts of white sugar, and 300˜400 wt. parts of water, based on 100 wt. parts of potassium carbonate. The composition exhibits excellent defense against the mortality caused by AIV H5N1, thus improving the survival of infected animals. As a supplement of a formulated feed mixture for farmed aquatic organisms, the composition provides excellent immunostimulation and disease resistance so as to decrease the mass mortality of aquatic organisms and to increase productivity. Particularly, when raised with a food in mixture with the composition, livestock and farmed aquatic organisms are immunologically improved so that they can endure and are protected against epidemic diseases caused by viruses and bacteria.

公开(公告)号：US09682086B2

公开(公告)日：2017-06-20

申请号：US15023181

申请日：2014-09-25

申请人： Háskóli Íslands ,  Sigriður Guðrún Suman

发明人： Sigrður Guðún Suman

IPC分类号： A61K31/555 ,  C07F11/00 ,  A61K33/04 ,  C07C211/05 ,  C07F17/00

CPC分类号： A61K31/555 ,  A61K33/04 ,  C07C211/05 ,  C07F11/005 ,  C07F17/00

摘要： The present invention relates to compositions comprising molybdenum compounds, novel molybdenum compounds, kits and methods for their preparation. In particular, the present invention relates to compositions comprising molybdenum compounds for use in the treatment of cyanide poisoning in mammals, in particular humans.

公开(公告)号：US20170165203A1

公开(公告)日：2017-06-15

申请号：US15387541

申请日：2016-12-21

申请人： ICEUTICA PTY LTD.

发明人： Aaron Dodd ,  H. William Bosch ,  Felix Meiser ,  Marck Norret ,  Adrian Russell

IPC分类号： A61K9/16 ,  B02C17/20 ,  A01N37/38 ,  A61K31/122 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/198 ,  A61K38/13 ,  A61K31/196 ,  A01N57/20 ,  A01N47/36 ,  A61K31/404 ,  A01N55/02 ,  A61K31/5415 ,  A61K31/421 ,  A61K31/192 ,  A61K31/57 ,  A61K31/137 ,  A61K33/04 ,  A01N25/10 ,  A01N25/12 ,  A61J3/02 ,  A23L33/10 ,  A23P10/20 ,  B02C19/00

CPC分类号： A61K9/1682 ,  A01N25/10 ,  A01N25/12 ,  A01N25/34 ,  A01N37/38 ,  A01N47/36 ,  A01N55/02 ,  A01N57/20 ,  A23L33/10 ,  A23P10/20 ,  A23P10/30 ,  A23V2002/00 ,  A61J3/02 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/122 ,  A61K31/137 ,  A61K31/18 ,  A61K31/192 ,  A61K31/196 ,  A61K31/198 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/421 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/53 ,  A61K31/5415 ,  A61K31/565 ,  A61K31/57 ,  A61K33/04 ,  A61K38/13 ,  B02C17/20 ,  B02C19/0056 ,  A01N39/04 ,  A01N47/14 ,  A01N57/12 ,  A01N59/02

摘要： The present invention relates to methods for producing nanoparticle and microparticle powders of a biologically active material which have improved powder handling properties making the powders suitable for commercial use using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.

公开(公告)号：US20170136050A1

公开(公告)日：2017-05-18

申请号：US15357230

申请日：2016-11-21

申请人： CORE INTELLECTUAL PROPERTIES HOLDINGS, LLC

发明人： Roger Blotsky ,  Krys Bojanowski ,  Ramon Figueroa ,  Reynold Dominguez

IPC分类号： A61K31/704 ,  A61K33/20 ,  A61K33/42 ,  A61K33/00 ,  A61K33/24 ,  A61K33/36 ,  A61K33/22 ,  A61K33/34 ,  A61K33/16 ,  A61K33/18 ,  A61K33/26 ,  A61K33/28 ,  A61K33/30 ,  A61K33/38 ,  A61K33/44 ,  A61K33/04 ,  A23L2/52 ,  A23L27/30 ,  A23L33/105 ,  A23L33/16 ,  A61K33/06

CPC分类号： A61K31/704 ,  A23K20/121 ,  A23L2/52 ,  A23L2/60 ,  A23L27/36 ,  A23L33/105 ,  A23L33/16 ,  A23V2002/00 ,  A61K31/7042 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/14 ,  A61K33/16 ,  A61K33/18 ,  A61K33/20 ,  A61K33/22 ,  A61K33/24 ,  A61K33/245 ,  A61K33/26 ,  A61K33/28 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/36 ,  A61K33/38 ,  A61K33/40 ,  A61K33/42 ,  A61K33/44 ,  A61K35/08 ,  A61K2300/00

摘要： The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation related conditions including diabetes, atherosclerosis, arthritis, mental conditions and vision impairment.