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    Drug Eluting Balloons with Ability for Double Treatment
    62.
    发明申请
    Drug Eluting Balloons with Ability for Double Treatment 审中-公开
    具有双重治疗能力的药物洗脱气球

    公开(公告)号：US20120150142A1

    公开(公告)日：2012-06-14

    申请号：US13310202

    申请日：2011-12-02

    申请人： Jan Weber ,  Jos Wetzels

    发明人： Jan Weber ,  Jos Wetzels

    IPC分类号： A61M25/10

    CPC分类号： A61M25/104 ,  A61L29/08 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/61 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088

    摘要： In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents.

    摘要翻译： 在实施例中，诸如气囊导管的医疗装置可将生物活性物质递送至患者的身体组织。 医疗装置包括海绵输送层，其可以将多个剂量的一种或多种治疗剂递送至身体组织。 医疗装置还可以包括药物储存器，其可以向输送层提供一种或多种治疗剂。

    CORE-SHEATH IMPLANT DEVICE HAVING AN INNER CORE LOBE
    63.
    发明申请
    CORE-SHEATH IMPLANT DEVICE HAVING AN INNER CORE LOBE 有权
    具有内核机芯的核心植入装置

    公开(公告)号：US20120004724A1

    公开(公告)日：2012-01-05

    申请号：US13171927

    申请日：2011-06-29

    申请人： Michael E. Hudson

    发明人： Michael E. Hudson

    IPC分类号： A61F2/02

    CPC分类号： A61K9/0024 ,  A61K9/0092 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/61

    摘要： The core-sheath implant device allows for a bioactive agent release profile that can be tailored to a particular therapy. The device features one or more lobes extending from an inner core at least partially through the outer sheath. Depending on the particular design of such an implant device, a variety of release profiles can be achieved.

    摘要翻译： 芯鞘植入装置允许可针对特定疗法定制的生物活性剂释放特征。 该装置具有从内芯至少部分地穿过外护套延伸的一个或多个凸角。 根据这种植入装置的具体设计，可以实现各种释放特征。

    Medical device having a coating comprising an adhesion promoter
    64.
    发明授权
    Medical device having a coating comprising an adhesion promoter 有权
    具有包含粘合促进剂的涂层的医疗装置

    公开(公告)号：US07879086B2

    公开(公告)日：2011-02-01

    申请号：US11409468

    申请日：2006-04-20

    申请人： Liza J Davis

    发明人： Liza J Davis

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L31/14 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/61

    摘要： This invention is directed to a coating for a medical device, such as an intravascular stent, in which the coating, which comprises a first coating region comprising an adhesion promoter and a therapeutic agent. The coating can also include a second coating region which is substantially free of the adhesion promoter or any adhesion promoter. The invention is also directed to a method for manufacturing such a coated medical device.

    摘要翻译： 本发明涉及用于医疗装置如血管内支架的涂层，其中涂层包括包含粘合促进剂和治疗剂的第一涂层区域。 涂层还可以包括基本上不含粘合促进剂或任何粘合促进剂的第二涂层区域。 本发明还涉及一种用于制造这种涂覆的医疗装置的方法。

    Endoprosthesis with Selective Drug Coatings
    65.
    发明申请
    Endoprosthesis with Selective Drug Coatings 审中-公开
    选择性药物涂层内置假体

    公开(公告)号：US20100274352A1

    公开(公告)日：2010-10-28

    申请号：US12429392

    申请日：2009-04-24

    申请人： Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    发明人： Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    IPC分类号： A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/61

    摘要： An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.

    摘要翻译： 诸如冠状动脉支架的内用假体包括管腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和腔内表面，其至少一部分被第二涂层覆盖，所述第二涂层包括第二药物 。 第一种药物基于第一种涂层具有第一洗脱分布，而第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。 还提供了制备其的方法。

    Marked precoated medical device and method of manufacturing same
    66.
    发明授权
    Marked precoated medical device and method of manufacturing same 有权
    标记预涂医疗器械及其制造方法

    公开(公告)号：US07811623B2

    公开(公告)日：2010-10-12

    申请号：US12402218

    申请日：2009-03-11

    申请人： Bruce Nesbitt

    发明人： Bruce Nesbitt

    IPC分类号： C08J7/18 ,  A61L33/00 ,  B05D3/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/442 ,  A61L2300/61 ,  A61L2420/02 ,  A61L2420/08 ,  B05D3/12 ,  B05D5/06 ,  B05D5/08 ,  B05D7/546 ,  B05D7/586

    摘要： A method of manufacturing a coated medical device, includes applying a first low-friction coating to a surface of the medical device. The first low-friction coating includes a first colored pigment, such as a relatively light colored pigment. After applying the first low-friction coating, a suitable laser and laser energy is selectively applied to different areas of the coated medical device. The laser ablates or removes the first low-friction coating (at the different areas of the medical device) to leave the bare metal substrate of the medical device exposed. After selectively removing one or more portions of the first low-friction coating, a second low-friction coating is applied to the exposed bare metal substrate of the medical device and suitably cured. The second low-friction coating includes a second colored pigment, such as a relatively dark colored pigment, wherein the second colored pigment contrasts the first colored pigment of the first low-friction coating.

    摘要翻译： 一种涂覆医疗装置的制造方法，包括将第一低摩擦涂层施加到医疗装置的表面。 第一低摩擦涂层包括第一着色颜料，例如较浅颜色的颜料。 在施加第一低摩擦涂层之后，将合适的激光和激光能量选择性地施加到涂覆的医疗装置的不同区域。 激光烧蚀或去除第一低摩擦涂层（在医疗装置的不同区域），以使医疗装置的裸露的金属基底露出。 在选择性地去除第一低摩擦涂层的一个或多个部分之后，将第二低摩擦涂层施加到医疗装置的暴露的裸露金属基底上，并适当地固化。 第二低摩擦涂层包括第二着色颜料，例如相对深色的颜料，其中第二着色颜料与第一低摩擦涂层的第一着色颜料对比。

    Combination of antimicrobial agents and bacterial interference to coat medical devices
    67.
    发明授权
    Combination of antimicrobial agents and bacterial interference to coat medical devices 有权
    抗微生物剂与细菌干扰的组合以覆盖医疗器械

    公开(公告)号：US07790183B2

    公开(公告)日：2010-09-07

    申请号：US10788060

    申请日：2004-02-26

    申请人： Rabih O. Darouiche ,  Richard Hull

    发明人： Rabih O. Darouiche ,  Richard Hull

    IPC分类号： A61F13/00 ,  A61F2/00 ,  A01N63/00 ,  A61K39/38 ,  A61K39/02 ,  A61K9/50 ,  A61K39/108 ,  A61K39/112 ,  A61L33/00

    CPC分类号： A61L29/08 ,  A61L29/005 ,  A61L29/16 ,  A61L2300/30 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/61 ,  A61L2420/02

    摘要： This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

    摘要翻译： 本发明涉及一种医疗器械的涂覆方法，包括以下步骤：向所述医疗器械表面的至少一部分施加抗微生物涂层和非致病细菌涂层，其中所述抗微生物和非病原菌 涂层抑制病原菌和真菌生物的生长。 用于细菌涂层的非致病细菌对抗微生物剂具有抗性。 此外，非致病性细菌层包括以下中的至少一种：活的全细胞，非活的全细胞或细胞结构或提取物。 抗微生物剂和非病原菌用于在一个容器或分开的容器中开发包含这些组合物的试剂盒。 该套件用于在植入哺乳动物之前涂覆导管。

    Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
    69.
    发明授权
    Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release 有权
    具有用于调节药物释放的聚电解质多层涂层区域的医疗制品

    公开(公告)号：US07744644B2

    公开(公告)日：2010-06-29

    申请号：US10805576

    申请日：2004-03-19

    申请人： Jan Weber ,  Rachel Neuendorf

    发明人： Jan Weber ,  Rachel Neuendorf

    IPC分类号： A61F2/06 ,  A61F2/02

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2400/12 ,  A61N1/05

    摘要： The medical articles which including the following: (a) a ceramic or metallic region whose surface includes a plurality of depressions, (b) a multilayer coating region including multiple polyelectrolyte layers deposited over the surface of the ceramic or metallic region; and (c) a therapeutic agent disposed beneath or within the multilayer coating region. According to another aspect of the present invention, medical articles are provided, which include: (a) a ceramic or metallic region, (b) a multilayer coating region including multiple polyelectrolyte layers deposited over a surface of the ceramic or metallic region, the multilayer coating region including a plurality of protuberances; and (c) a therapeutic agent disposed within regions beneath the protuberances. Also described herein are methods of making such medical articles, and methods of administering a therapeutic agent to a patent using such medical articles.

    摘要翻译： 包括以下的医疗制品：（a）其表面包括多个凹陷的陶瓷或金属区域，（b）包括沉积在陶瓷或金属区域的表面上的多个聚电解质层的多层涂层区域; 和（c）设置在所述多层涂覆区域的下方或内部的治疗剂。 根据本发明的另一方面，提供了医疗用品，其包括：（a）陶瓷或金属区域，（b）多层涂层区域，其包含沉积在陶瓷或金属区域的表面上的多个聚电解质层，多层膜 涂覆区域包括多个突起; 和（c）设置在突起下方的区域内的治疗剂。 本文还描述了制造这种医疗制品的方法，以及使用这种医疗制品向专利施用治疗剂的方法。