公开(公告)号：US4806668A

公开(公告)日：1989-02-21

申请号：US110745

申请日：1987-08-07

Applicant: Bernd Raduechel ,  Werner Skuballa ,  Helmut Vorbrueggen

Inventor： Bernd Raduechel ,  Werner Skuballa ,  Helmut Vorbrueggen

IPC: C07C47/198 ,  C07C45/00 ,  C07C45/59 ,  C07C45/60 ,  C07C47/277 ,  C07C49/753 ,  C07C67/00 ,  C07C405/00 ,  C07F7/18 ,  C07F7/08

CPC classification number: C07C405/00 ,  C07C45/59 ,  C07C45/60 ,  C07C47/277 ,  C07C49/753

Abstract: The invention relates to a process for the production of (5-chloro-3-hydroxycyclopentyl) acetaldehydes of formula II ##STR1## in which R signifies a benzyl radical, a tert-butyldimethylsilyl radical or a tert-butyldiphenylsilyl radical, characterized in that a compound of formula I ##STR2## in which R has the meanings already mentioned, is reduced in the presence of a reduction agent.

Abstract translation: PCT No.PCT / DE86 / 00483 Sec。 371日期1987年8月7日 102（e）日期1987年8月7日PCT公布1986年11月28日PCT公布。 公开号WO87 / 03582 日期：1987年6月18日。本发明涉及制备式II的（5-氯-3-羟基环戊基）乙醛的方法，其中R表示苄基，叔丁基二甲基甲硅烷基或叔丁基二甲基甲硅烷基 丁基二苯基甲硅烷基，其特征在于其中R具有上述含义的式I的化合物在还原剂的存在下还原。

公开(公告)号：US4789754A

公开(公告)日：1988-12-06

申请号：US849070

申请日：1986-04-07

Applicant: Michael Elliott ,  Norman F. Janes ,  Richard L. Elliott ,  Bhupinder P. S. Khambay ,  David A. Pulman

Inventor： Michael Elliott ,  Norman F. Janes ,  Richard L. Elliott ,  Bhupinder P. S. Khambay ,  David A. Pulman

IPC: C07C17/16 ,  A01N53/00 ,  A01N53/06 ,  C07C17/00 ,  C07C22/04 ,  C07C27/00 ,  C07C29/14 ,  C07C33/22 ,  C07C33/30 ,  C07C45/59 ,  C07C45/62 ,  C07C47/548 ,  C07C67/00 ,  C07C67/03 ,  C07C67/08 ,  C07C67/10 ,  C07C67/14 ,  C07C69/08 ,  C07C69/743 ,  C07C69/747 ,  C07C253/00 ,  C07C255/32 ,  C07C255/34 ,  C07C255/35 ,  C07C255/36 ,  C07C255/39 ,  C07C255/53 ,  C07D317/12 ,  C07C121/52

CPC classification number: C07C255/00 ,  A01N53/00 ,  C07C29/14 ,  C07C33/30 ,  C07C45/59 ,  C07C45/62 ,  C07C47/548 ,  C07D317/12 ,  C07B2200/09

Abstract: A compound of the formula: ##STR1## wherein Y represents OH or a halogeno group;D represents hydrogen or a cyano group;B represents hydrogen or a methyl, ethyl or vinyl group;A represents methyl;n is 0, 1 or 2;with the proviso that(1) when the CH.sub.2 CH.dbd.CHB group is in the 4-position with respect to the CHDY group, then D must be hydrogen and B must be methyl, ethyl or vinyl and the configuration about the double bond in the CH.dbd.CHB group must be Z and(2) when the group CH.dbd.CHB is in the 3-position with respect to the CHDY group and D is CN then n must be 0 and(3) when the group CH.sub.2 CH.dbd.CHB is in the 2 or 3-position with respect to the CHDY group, then D is CN, are useful in the production of pesticidal esters of chrysanthemic and related acids.

Abstract translation: 下式的化合物：其中Y表示OH或卤代基; D表示氢或氰基; B表示氢或甲基，乙基或乙烯基; A代表甲基; n为0,1或2; 条件是（1）当CH 2 CH = CHB基团相对于CHDY基团处于4-位时，则D必须是氢，B必须是甲基，乙基或乙烯基，并且在CH中的双键构型 = CHB组必须为Z，（2）当组CH = CHB相对于CHDY组为3位时，D为CN，则n必须为0，（3）当CH 2 CH = CHB基为 相对于CHDY组为2或3位，则D为CN，可用于生产菊花和相关酸的杀虫剂。

公开(公告)号：US4777288A

公开(公告)日：1988-10-11

申请号：US60577

申请日：1987-06-11

Applicant: George J. Quallich ,  Michael T. Williams

Inventor： George J. Quallich ,  Michael T. Williams

IPC: C07D307/82 ,  B01J27/125 ,  C07B61/00 ,  C07C45/00 ,  C07C45/45 ,  C07C45/46 ,  C07C45/59 ,  C07C49/697 ,  C07C51/00 ,  C07C51/09 ,  C07C51/347 ,  C07C51/353 ,  C07C51/367 ,  C07C57/58 ,  C07C59/56 ,  C07C67/00 ,  C07D307/30 ,  C07D307/33 ,  C07C63/33 ,  C07D307/26

CPC classification number: C07D307/33 ,  C07C45/46 ,  C07C45/59 ,  C07C49/697 ,  C07C51/09 ,  C07C51/367

Abstract: A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to cis-(1S)(4S)- -N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds.

公开(公告)号：US4769464A

公开(公告)日：1988-09-06

申请号：US681904

申请日：1984-12-17

Applicant: Alexander Sajtos

Inventor： Alexander Sajtos

IPC: C07D211/48 ,  C07B41/06 ,  C07C41/50 ,  C07C45/00 ,  C07C45/40 ,  C07C45/41 ,  C07C45/59 ,  C07C47/02 ,  C07C47/12 ,  C07C47/198 ,  C07C47/20 ,  C07C47/28 ,  C07C47/38 ,  C07C47/52 ,  C07C47/542 ,  C07C47/544 ,  C07C49/04 ,  C07C49/12 ,  C07C49/20 ,  C07C67/00 ,  C07C67/313 ,  C07C69/003 ,  C07C69/67 ,  C07C69/716 ,  C07C313/00 ,  C07C315/04 ,  C07C317/24 ,  C07D213/48 ,  C07D213/50

CPC classification number: C07C45/40 ,  C07C201/12 ,  C07C315/00 ,  C07C45/59 ,  C07C47/02 ,  C07C47/12 ,  C07C47/198 ,  C07C47/542 ,  C07C47/544 ,  C07C49/12 ,  C07C67/313 ,  C07D213/48

Abstract: The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.

Abstract translation: 本发明涉及通过使分子中具有一个或多个烯属或芳族双键的有机碳化合物与等量的臭氧反应并随后催化氢化臭氧化产物来制备单羰基或双羰基化合物的方法，其中过氧化物 - 将含有臭氧化的溶液连续加入到低级脂肪醇中的氢化催化剂的悬浮液中，同时保持不超过0.1摩尔/升的过氧化物含量，并且臭氧化产物被还原性地连续裂解以得到相应的羰基化合物。

公开(公告)号：US4691033A

公开(公告)日：1987-09-01

申请号：US811403

申请日：1985-12-20

Applicant: James E. Hardwicke, III

Inventor： James E. Hardwicke, III

IPC: C07C41/48 ,  C07C45/51 ,  C07C45/59 ,  C07C47/575 ,  C07D317/16 ,  C07D317/22 ,  C07D317/34

CPC classification number: C07D317/22 ,  C07C41/48 ,  C07C45/515 ,  C07C45/59 ,  C07D317/16

Abstract: 3-Phenoxybenzaldehyde acetals can be prepared by reacting a 3-bromobenzalkehyde acetal with an alkali metal phenolate at a temperature of about 130.degree.-165.degree. C. in the presence of a copper catalyst and a phenol as the sole solvent. The product acetals can be converted to the corresponding 3-phenoxybenzaldehydes by hydrolysis.

Abstract translation: 3-苯氧基苯甲醛缩醛可以通过在约130-116℃的温度下，在铜催化剂和苯酚作为唯一溶剂的存在下使3-溴亚苄基醇缩醛与碱金属酚盐反应来制备。 产物缩醛可通过水解转化为相应的3-苯氧基苯甲醛。

公开(公告)号：US4676604A

公开(公告)日：1987-06-30

申请号：US586471

申请日：1984-03-05

Applicant: Martin Petrzilka

Inventor： Martin Petrzilka

IPC: C07C13/28 ,  C07C43/162 ,  C07C43/215 ,  C07C43/225 ,  C07C45/00 ,  C07C45/29 ,  C07C45/59 ,  C07C49/223 ,  C07C49/687 ,  C07C49/798 ,  C07C61/35 ,  C07C69/75 ,  C07C69/76 ,  C07C255/50 ,  C07C255/51 ,  C07D303/04 ,  C07D303/14 ,  C07D303/16 ,  C07D303/22 ,  C07D303/46 ,  C07D317/72 ,  C07D319/06 ,  C09K19/08 ,  C09K19/12 ,  C09K19/14 ,  C09K19/20 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  G02F1/13 ,  C07C121/00

CPC classification number: C07D303/22 ,  C07C13/28 ,  C07C255/00 ,  C07C403/02 ,  C07C43/162 ,  C07C43/215 ,  C07C45/004 ,  C07C45/292 ,  C07C45/59 ,  C07C49/687 ,  C07C49/798 ,  C07C61/35 ,  C07D303/04 ,  C07D303/14 ,  C07D303/16 ,  C07D303/46 ,  C07D317/72 ,  C07D319/06 ,  C09K19/14 ,  C09K19/2007 ,  C09K19/3001 ,  C09K19/3402 ,  C09K19/3441 ,  C07C2101/14 ,  C09K2019/3422

Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or straight-chain alkyl; R.sup.2 is --CN, --R, --COR, --COOR or when R.sup.2 is positioned on an aromatic ring R.sup.2 also can be --OR, --OOCR or --F; R is alkyl; A is a group with 1 to 4 six-membered rings, these rings being linked directly with one another and with ring B in each case via a single covalent bond or being linked at one or two positions also via --COO--, --OOC-- or --CH.sub.2 CH.sub.2 --; the six-membered rings in A and ring B each are 1,4-phenylene or trans-1,4-cyclohexylene or one of these rings also is trans-2,5-disubstituted m-dioxane, 2,5-disubstituted pyrimidine or 3,6-disubstituted pyridazine, with the proviso that a maximum of two adjacent trans-1,4-cyclohexylene rings are linked directly via a single covalent bond; and m is the integer 2, or when ring B is trans-1,4-cyclohexylene or trans-2,5-disubstituted m-dioxane, m also can be the integer 0, their manufacture, liquid crystalline mixtures which contain these compounds as well as the use of these compounds for electro-optical purposes are described.Additionally, compounds of the formula ##STR2## wherein R.sup.8 is straight-chain C.sub.1 -C.sub.12 alkyl, their manufacture, liquid crystalline mixtures which contain these compounds and their use for electro-optical purposes are described.

Abstract translation: 式Ⅰ的化合物，其中R 1是氢或直链烷基; R2是-CN，-R，-COR，-COOR或当R2位于芳环R2时也可以是-OR，-OOCR或-F; R是烷基; A是具有1至4个六元环的基团，这些环彼此直接连接，并且在每种情况下通过单个共价键连接，或者也可以通过-COO - ， - OOC- 或-CH 2 CH 2 - ; A和环B中的六元环各自为1,4-亚苯基或反式-1,4-亚环己基，或者这些环中的一个也是反式-2,5-二取代的间二氧杂环己烷，2,5-二取代的嘧啶或 3,6-二取代哒嗪，条件是最多两个相邻的反式-1,4-亚环己基环通过单个共价键直接相连; 并且m是整数2，或者当环B是反式-1,4-亚环己基或反式-2,5-二取代的间二恶烷时，m也可以是整数0，它们的制造，含有这些化合物的液晶混合物为 以及这些化合物用于电光目的的描述。 另外，还描述了其中R8是直链C1-C12烷基的式“IMAGE”LXXVIII的化合物，它们的制备，含有这些化合物的液晶混合物及其用于电光学目的的用途。

公开(公告)号：US4629581A

公开(公告)日：1986-12-16

申请号：US749160

申请日：1985-06-26

Applicant: Arthur Boller ,  Martin Petrzilka ,  Martin Schadt

Inventor： Arthur Boller ,  Martin Petrzilka ,  Martin Schadt

IPC: C07C2/54 ,  C07C13/28 ,  C07C15/28 ,  C07C41/00 ,  C07C43/215 ,  C07C45/59 ,  C07C45/68 ,  C07C67/00 ,  C07C69/75 ,  C07C69/773 ,  C07C253/00 ,  C07C255/45 ,  C07C255/46 ,  C09K19/30 ,  G02F1/13 ,  G09F9/35 ,  C09K3/34 ,  C07C121/46

CPC classification number: C07C403/02 ,  C07C255/00 ,  C07C403/10 ,  C07C45/59 ,  C07C45/68 ,  C09K19/3001 ,  C07C2101/14

Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or straight-chain alkyl; R.sup.2 is --CN, --R, --COR, --COOR or when R.sup.2 is positioned on an aromatic ring R.sup.2 also can be --OR, --OOCR or --F; R is alkyl; A is a group with 1 to 4 six-membered rings, these rings being linked directly with one another and with ring B in each case via a single covalent bond or being linked at one or two positions also via --COO--, --OOC-- or --CH.sub.2 CH.sub.2 --; the six-membered rings in A and ring B each are 1,4-phenylene or trans-1,4-cyclohexylene or one of these rings also is trans-2,5-disubstituted m-dioxane, 2,5-disubstituted pyrimidine or 3,6-disubstituted pyridazine, with the proviso that a maximum of two adjacent trans-1,4-cyclohexylene rings are linked directly via a single covalent bond; and m is the integer 2, or when ring B is trans-1,4-cyclohexylene or trans-2,5-disubstituted m-dioxane, m also can be the integer 0,their manufacture, liquid crystalline mixtures which contain these compounds as well as the use of these compounds for electro-optical purposes are described.Additionally, compounds of the formula ##STR2## wherein R.sup.8 is straight-chain C.sub.1 -C.sub.12 alkyl, their manufacture, liquid crystalline mixtures which contain these compounds and their use for electro-optical purposes are described.

Abstract translation: 式Ⅰ的化合物，其中R 1是氢或直链烷基; R2是-CN，-R，-COR，-COOR或当R2位于芳环R2时也可以是-OR，-OOCR或-F; R是烷基; A是具有1至4个六元环的基团，这些环彼此直接连接，并且在每种情况下通过单个共价键连接，或者也可以通过-COO - ， - OOC- 或-CH 2 CH 2 - ; A和环B中的六元环各自为1,4-亚苯基或反式-1,4-亚环己基，或者这些环中的一个也是反式-2,5-二取代的间二氧杂环己烷，2,5-二取代的嘧啶或 3,6-二取代哒嗪，条件是最多两个相邻的反式-1,4-亚环己基环通过单个共价键直接相连; 并且m是整数2，或者当环B是反式-1,4-亚环己基或反式-2,5-二取代的间二恶烷时，m也可以是整数0，它们的制造，含有这些化合物的液晶混合物为 以及这些化合物用于电光目的的描述。 另外，还描述了其中R8是直链C1-C12烷基的式“IMAGE”LXXVIII的化合物，它们的制备，含有这些化合物的液晶混合物及其用于电光学目的的用途。

公开(公告)号：US4564477A

公开(公告)日：1986-01-14

申请号：US467253

申请日：1983-02-17

Applicant: Tetsuo Takigawa ,  Koichi Ibata ,  Masafumi Okada ,  Masao Mizuno ,  Takashi Nishida

Inventor： Tetsuo Takigawa ,  Koichi Ibata ,  Masafumi Okada ,  Masao Mizuno ,  Takashi Nishida

IPC: C07C29/14 ,  C07C29/147 ,  C07C45/29 ,  C07C45/30 ,  C07C45/59 ,  C07C45/67 ,  C07C47/21 ,  C07C49/203 ,  C07C57/03 ,  C07C69/587 ,  C07D295/02 ,  C07D295/03 ,  C07D295/185 ,  C09F5/00

CPC classification number: C07D295/185 ,  C07C255/00 ,  C07C29/14 ,  C07C29/147 ,  C07C45/292 ,  C07C45/298 ,  C07C45/305 ,  C07C45/59 ,  C07C45/676 ,  C07C47/21 ,  C07C49/203 ,  C07C57/03 ,  C07D295/03

Abstract: There are provided polyprenyl compounds of the formula ##STR1## wherein ##STR2## represent a trans-isoprene unit and a cis-isoprene unit, respectively, n is an integer of 11-19, Z.sup.1 and Z.sup.2 combinedly represent .dbd.O, .dbd.CH--COOH,.dbd.CH--COOR.sup.1, .dbd.CH--CN, .dbd.C(CN)COOR.sup.2, .dbd.CH--CO--NH.sub.2, .dbd.CH--CO--N(R.sup.3) (R.sup.4), .dbd.CH--CO--NHR.sup.5, .dbd.CH--CH.sub.2 --N(R.sup.3) (R.sup.4), .dbd.CH--CH.sub.2 --NHR.sup.5 or .dbd.CH--CHO or Z.sup.1 is a hydrogen atom and Z.sup.2 is --CH.sub.2 COOH, --CH.sub.2 COOR.sup.6, --CH(CN)COOR.sup.2, --CH.sub.2 CN, --CH.sub.2 --CO--NH.sub.2, --CH.dbd.CH--N(R.sup.3) (R.sup.4) or --CH.sub.2 --CH.dbd.N--R.sup.5, R.sup.1, R.sup.2 and R.sup.6 each being a lower alkyl group, R.sup.3 and R.sup.4 each independently being a lower-alkyl, cycloalkyl, aryl or aralkyl group or R.sup.3 and R.sup.4 combinedly representing an alkylene group containing 2-5 carbon atoms, and R.sup.5 being a lower-alkyl, cycloalkyl, aryl or aralkyl group. These polyprenyl compounds can be synthesized starting with a polyprenol obtainable from leaves of a plant such as Ginkgo biloba or Cedrus deodara by extraction and as necessary followed by hydrolysis, or a reactive derivative thereof. The polyprenyl compounds are useful as intermediates for the synthesis of dolichol without the use of an expensive C.sub.5 chain extender.

Abstract translation: 提供下式的聚异戊二烯基化合物：其中，“IMAGE”分别代表异戊二烯单元和顺式异戊二烯单元，n为11-19的整数，Z1和Z2组合表示 = CH 2 COOR 1 = CH-COOR 1 = CH-CN = C（CN）COOR 2 = CH-CO-NH 2 = CH-CO-N（R3）（R4） NHR 5，= CH-CH 2 -N（R 3）（R 4），= CH-CH 2 -NHR 5或= CH-CHO或Z 1是氢原子，Z 2是-CH 2 COOH，-CH 2 COOR 6，-CH（CN）COOR 2，-CH 2 CN ，-CH 2 -CO-NH 2，-CH = CH-N（R 3）（R 4）或-CH 2 -CH = N-R 5，R 1，R 2和R 6各自为低级烷基，R 3和R 4各自独立地为低级 - 烷基，环烷基，芳基或芳烷基或R3和R4组合表示含2-5个碳原子的亚烷基，R5为低级烷基，环烷基，芳基或芳烷基。 这些聚异戊二烯基化合物可以从通过提取从植物如银杏叶或Cedrus deodara的叶获得的聚异戊二烯开始合成，并且根据需要随后进行水解或其活性衍生物合成。 聚异戊二烯基化合物可用作合成Dolichol而不使用昂贵的C5扩链剂的中间体。

公开(公告)号：US4529812A

公开(公告)日：1985-07-16

申请号：US558471

申请日：1983-12-06

Applicant: Paul W. Collins ,  Richard M. Weier

Inventor： Paul W. Collins ,  Richard M. Weier

IPC: C07C45/59 ,  C07C59/90 ,  C07C405/00 ,  C07D307/42 ,  C07D407/12 ,  C07F7/18 ,  C07C177/00

CPC classification number: C07D307/42 ,  C07C405/0025 ,  C07C45/59 ,  C07C59/90 ,  C07D407/12 ,  C07F7/1856

Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.

Abstract translation: 本发明涉及E2系列的新型3-氧杂-15-脱氧-16-羟基-16-烷基前列腺素及其5,6-炔炔衍生物。 这些化合物可用于其胃分泌，细胞保护，抗溃疡和抗高血压活性。 此外，本发明还公开了某些新的三烷基甲硅烷基炔属中间体。

公开(公告)号：US4517385A

公开(公告)日：1985-05-14

申请号：US636226

申请日：1984-07-31

Applicant: Kenneth K. Light ,  William L. Schreiber ,  Joseph A. McGhie ,  Ronald P. Schreck ,  Takao Yoshida ,  Loren B. Schreiber ,  Ranya Muralidhara

Inventor： Kenneth K. Light ,  William L. Schreiber ,  Joseph A. McGhie ,  Ronald P. Schreck ,  Takao Yoshida ,  Loren B. Schreiber ,  Ranya Muralidhara

IPC: A24B15/32 ,  C07C45/42 ,  C07C45/59 ,  C07C45/66 ,  C07C49/12 ,  C07C49/203 ,  C07D295/02 ,  C07D295/03 ,  C07D295/145 ,  C07D295/155 ,  C07D309/28 ,  C07D317/28 ,  C07D317/30 ,  C07C49/16

CPC classification number: C07D295/03 ,  A24B15/32 ,  C07C255/00 ,  C07C45/42 ,  C07C45/59 ,  C07C45/66 ,  C07C49/203 ,  C07D295/145 ,  C07D295/155 ,  C07D309/28 ,  C07D317/28 ,  C07D317/30

Abstract: Described is a process for preparing solanone and norsolanadione, both useful as tobacco flavorants.

Abstract translation: 描述了一种制备可用作烟草香料的Solone和Norsolanadione的方法。