公开(公告)号：US07410807B2

公开(公告)日：2008-08-12

申请号：US10349715

申请日：2003-01-23

申请人： Vito J. D'Aurora

发明人： Vito J. D'Aurora

IPC分类号： G01N33/53

CPC分类号： A61D17/006 ,  G01N33/74 ,  G01N33/743 ,  Y10S436/811 ,  Y10S436/814

摘要： A method of testing an animal for pregnancy or sex identification comprising the steps of first, providing a first vessel containing a liquid and having a removable surface wherein said removable surface is at least partially coated with an antibody and then introducing a bodily fluid from the female animal into said first vessel so that said bodily fluid contacts the liquid and then manipulating the first vessel so that the liquid contacts the antibody. Then, a second vessel containing a reporter hormone solution is provided and the removable surface from the first vessel is displaced to the second vessel and manipulating the second vessel so that the reporter hormone solution contacts the removable surface. Then, a third vessel containing an indicating solution which has an appearance which is related to the amount of the reporter hormone contacted is provided, and the removable surface is displaced from the second vessel to the third vessel. The third vessel is manipulated so that the indicating solution contacts the removable surface. Then, a determination is made regarding the pregnancy or sex of the animal based on the appearance of the indicating solution.

摘要翻译： 一种测试用于妊娠或性别鉴定的动物的方法，包括以下步骤：首先，提供含有液体并具有可移除表面的第一容器，其中所述可移除表面至少部分地涂覆有抗体，然后从所述女性引入体液 动物进入所述第一容器，使得所述体液接触液体，然后操纵第一容器，使得液体接触抗体。 然后，提供含有报告激素溶液的第二容器，将来自第一容器的可移除表面置换到第二容器并操纵第二容器，使得报告激素溶液接触可除去的表面。 然后，提供含有与接触的报告激素的量相关的外观的指示液的第三容器，并且可移除表面从第二容器移位到第三容器。 操作第三容器使得指示溶液接触可除去的表面。 然后，根据指示液的外观判定动物的妊娠或性别。

公开(公告)号：US07407813B2

公开(公告)日：2008-08-05

申请号：US10328402

申请日：2002-12-23

申请人： Paul James Davis ,  Michael Evans Prior ,  Keith May

发明人： Paul James Davis ,  Michael Evans Prior ,  Keith May

IPC分类号： G01N33/558 ,  G01N33/53 ,  G01N21/00 ,  G01N15/06 ,  C12Q1/00 ,  C12Q1/68 ,  C12M1/34 ,  C12M3/00 ,  B32B5/02

CPC分类号： G01N33/54386 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/806 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/818

摘要： An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilised in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reaction in the presence of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, eg. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body.

公开(公告)号：US07399636B2

公开(公告)日：2008-07-15

申请号：US10335115

申请日：2002-12-31

申请人： John F. O'Connor ,  Galina I. Kovalevskaya ,  Steven Birken

发明人： John F. O'Connor ,  Galina I. Kovalevskaya ,  Steven Birken

IPC分类号： G01N33/48 ,  G01N33/53 ,  C07K16/00

CPC分类号： G01N33/76 ,  C07K14/59 ,  C07K16/26 ,  G01N33/57434 ,  G01N33/57449 ,  G01N2333/59 ,  Y10S435/971 ,  Y10S436/811 ,  Y10S436/814 ,  Y10S436/818

摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG is a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定早期妊娠相关hCG是样品的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。

公开(公告)号：US20080034445A1

公开(公告)日：2008-02-07

申请号：US11890114

申请日：2007-08-03

申请人： Sanjiv Gambhir ,  Ramasamy Paulmurugan

发明人： Sanjiv Gambhir ,  Ramasamy Paulmurugan

IPC分类号： A01K67/027 ,  C12Q1/68 ,  C12N9/06

CPC分类号： C12Q1/6897 ,  A01K2217/05 ,  A01K2267/0393 ,  C07K2319/00 ,  C12N2830/002 ,  G01N33/5008 ,  G01N33/542 ,  G01N33/743 ,  G01N2333/723 ,  Y10S436/814

摘要： Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable transactivation systems, reporter polynucleotides, method of producing reporter polynucleotides, activator fusion proteins, methods of producing activator fusion proteins, methods of regulating gene expression in vitro and in vivo for gene therapy, methods of screening estrogen receptor modulators with therapeutic treatments (e.g., anticancer, antiosteoporosis, and hormone replacement treatments), method of screening compounds (e.g., drugs and environmental pollutants) for the estrogenic effect, methods of evaluating the estrogen receptor pathway under different pathological conditions are provided, and the like.

摘要翻译： 简要描述，本公开的实施方案包括配体可调节反式激活系统，产生配体可调节反式激活系统的方法，使用配体可调节反式激活系统的方法，报告多核苷酸，产生报告多核苷酸的方法，活化融合蛋白，产生活化融合蛋白的方法 蛋白质，体外和体内基因治疗基因表达的方法，用治疗性治疗（例如抗癌，抗骨质疏松症和激素替代治疗）筛选雌激素受体调节剂的方法，筛选化合物（例如药物和环境污染物）的方法， 对于雌激素效应，提供了在不同病理条件下评价雌激素受体途径的方法等。

公开(公告)号：US07270970B2

公开(公告)日：2007-09-18

申请号：US10877122

申请日：2004-06-25

申请人： Emory V. Anderson ,  Edward Nemec ,  Jerome P. Lapointe ,  Duane DeSieno ,  Ricardo R. Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei

发明人： Emory V. Anderson ,  Edward Nemec ,  Jerome P. Lapointe ,  Duane DeSieno ,  Ricardo R. Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei

IPC分类号： G01N33/53 ,  G01N21/76 ,  G01N21/00 ,  G01N21/01 ,  G01N21/62 ,  G01N21/63 ,  G01N21/64 ,  G01N21/25 ,  G01N21/41 ,  G01N21/47

CPC分类号： G01N21/474 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/6887 ,  G01N33/689 ,  G01N2333/78 ,  G01N2800/368 ,  G06F19/00 ,  G06F19/321 ,  G16H10/40 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  Y02A90/26 ,  Y10S436/811 ,  Y10S436/814

摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.

摘要翻译： 提供了用于医疗诊断或患者风险评估的系统和方法。 这些系统和方法被设计为在护理点使用，例如在急诊室和手术室中，或在需要快速和准确的结果的任何情况下使用。 系统和方法处理患者数据，特别是来自护理诊断测试或测定的数据，包括免疫测定，心电图，X射线和其他此类测试，并提供医疗状况或其风险或不存在的指示。 系统包括用于读取或评估测试数据的工具，以及用于将数据转换为诊断或风险评估信息的软件。

公开(公告)号：US07238537B2

公开(公告)日：2007-07-03

申请号：US09944389

申请日：2001-09-04

申请人： Paul James Davis ,  Michael Evans Prior ,  Keith May

发明人： Paul James Davis ,  Michael Evans Prior ,  Keith May

IPC分类号： G01N33/53

CPC分类号： G01N33/54386 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/806 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/818

摘要： An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilized in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reaction in the presence of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, eg. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body.

摘要翻译： 包含干多孔载体的分析测试装置，液体样品例如 怀疑含有分析物如HCG或LH的尿液可以间接施用，该装置还包含标记的特异性结合试剂，其在处于潮湿状态时可在多孔载体中自由移动，以及永久固定的未标记的特异性结合试剂 在载体材料上的检测区域中，标记和未标记的特异性结合试剂能够在分析物存在下参与夹心反应或竞争反应，其中在将液体样品的装置应用于怀疑 含有分析物时，标记的特异性结合试剂在大孔体内保持干燥状态，例如。 的孔径为10微米或更大的塑料材料，所施加的液体样品通过该材料必须通过多孔载体材料，标记的特异性结合试剂可自由溶解或分散在进入大孔体的任何液体样品中。

公开(公告)号：US20070148631A1

公开(公告)日：2007-06-28

申请号：US10565686

申请日：2004-07-12

申请人： David Wright

发明人： David Wright

IPC分类号： C12Q1/00

CPC分类号： G01N33/743 ,  G01N33/76 ,  G01N2333/471 ,  G01N2333/575 ,  G01N2800/387 ,  Y10S436/811 ,  Y10S436/814

摘要： This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for said chromosomal abnormality, the method comprising: receiving first data from a first stage of pregnancy of said mother, said first data comprising data representing a first value of said first biological parameter, receiving second data from a second, later stage of said pregnancy, said second data comprising data representing a second value of said first biological parameter, and determining likelihood data from said first and second data, said likelihood data representing the likelihood of said fetus having a chromosomal abnormality.

摘要翻译： 本发明一般涉及用于染色体异常的产前筛查的方法，装置和计算机程序代码，特别是唐氏综合征。 一种确定由具有染色体异常的怀孕母亲携带的胎儿的可能性的方法，第一生物学参数适合于筛选所述胎儿用于所述染色体异常，所述方法包括：从所述第一阶段怀孕所述第一数据 母亲，所述第一数据包括表示所述第一生物参数的第一值的数据，从所述怀孕的第二后期接收第二数据，所述第二数据包括表示所述第一生物参数的第二值的数据，以及从 所述第一和第二数据，所述可能性数据表示所述胎儿具有染色体异常的可能性。

公开(公告)号：US07192786B1

公开(公告)日：2007-03-20

申请号：US08487623

申请日：1995-06-07

申请人： Timo Nils-Erik Lövgren ,  Antti Juhana Iitiä ,  Kim Sverker Immanuel Pettersson

发明人： Timo Nils-Erik Lövgren ,  Antti Juhana Iitiä ,  Kim Sverker Immanuel Pettersson

IPC分类号： G01N33/546 ,  G01N33/54 ,  G01N33/53

CPC分类号： C12Q1/6834 ,  G01N33/54313 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S435/973 ,  Y10S436/80 ,  Y10S436/814 ,  Y10S436/818 ,  Y10S436/825

摘要： This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signal strength from the labelled bioaffinity reactant B bound to the microparticles is quantitated for the determination of the concentration of the analyte in the sample. According to the invention, such an amount of sample and microparticles is used in the assay that after binding of the analyte of the sample to the said amount of microparticles, each individual microparticle will emit such a signal strength as to allow the measurement of the analyte concentration over the whole range of typical analyte concentrations, and the signal strength from each microparticle is measured separately.

摘要翻译： 本发明涉及生物特异性测定方法，其中用生物亲和反应物A包被的微粒与待测定的分析物结合; 待分析的样品和标记的生物亲和反应物B混合。 在结合反应之后，定量与微粒结合的标记的生物亲和反应物B的信号强度用于测定样品中分析物的浓度。 根据本发明，在测定中使用这种量的样品和微粒，在将样品的分析物与所述量的微粒结合后，每个单独的微粒将发射这样的信号强度，以允许测量分析物 浓度超过典型分析物浓度的整个范围，并且分别测量每个微粒的信号强度。

公开(公告)号：US07179640B2

公开(公告)日：2007-02-20

申请号：US11327119

申请日：2006-01-06

申请人： Nancy Tommye Jordan ,  John Douglas Jordan

发明人： Nancy Tommye Jordan ,  John Douglas Jordan

IPC分类号： G01N33/558

CPC分类号： G01N33/54386 ,  C07K14/47 ,  C07K16/18 ,  G01N33/558 ,  G01N2800/367 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/814

摘要： The present invention provides antibodies which specifically bind early conception factor, which can be found in body fluids of animals including but not limited to the cow, cat, dog, horse, human, sheep, and pig. The invention provides methods for detecting conception or the absence of conception in an animal, the latter being recognized by the absence of early conception factor in a suitable body fluid collected from the animal. Apparati for detecting early conception factor in a body fluid from an animal comprising the antibodies which specifically bind early conception factor are also provided.

摘要翻译： 本发明提供特异性结合早期受孕因子的抗体，其可以在动物的体液中发现，包括但不限于牛，猫，狗，马，人，绵羊和猪。 本发明提供了用于检测动物中的受孕或不存在受孕的方法，后者通过在从动物收集的合适的体液中不存在早期受孕因子来识别。 还提供了用于检测来自包含特异性结合早期受孕因子的抗体的动物的体液中的早期受孕因子的装置。

公开(公告)号：US20060105470A1

公开(公告)日：2006-05-18

申请号：US11327119

申请日：2006-01-06

申请人： Nancy Jordan ,  John Jordan

发明人： Nancy Jordan ,  John Jordan

IPC分类号： G01N33/558

CPC分类号： G01N33/54386 ,  C07K14/47 ,  C07K16/18 ,  G01N33/558 ,  G01N2800/367 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/814

摘要： The present invention provides antibodies which specifically bind early conception factor, which can be found in body fluids of animals including but not limited to the cow, cat, dog, horse, human, sheep, and pig. The invention provides methods for detecting conception or the absence of conception in an animal, the latter being recognized by the absence of early conception factor in a suitable body fluid collected from the animal. Apparati for detecting early conception factor in a body fluid from an animal comprising the antibodies which specifically bind early conception factor are also provided.

摘要翻译： 本发明提供特异性结合早期受孕因子的抗体，其可以在动物的体液中发现，包括但不限于牛，猫，狗，马，人，绵羊和猪。 本发明提供了用于检测动物中的受孕或不存在受孕的方法，后者通过在从动物收集的合适的体液中不存在早期受孕因子来识别。 还提供了用于检测来自包含特异性结合早期受孕因子的抗体的动物的体液中的早期受孕因子的装置。