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162 条记录 (耗时 0.051 秒)

    IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS
    64.
    发明申请
    IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS 审中-公开
    通过核酸三磷酸盐输送机将未经修饰的核核​​苷酸磷酸酯进入细胞

    公开(公告)号：US20170029829A1

    公开(公告)日：2017-02-02

    申请号：US15302874

    申请日：2015-04-09

    申请人： The Scripps Research Institute

    发明人： Floyd E. ROMESBERG ,  Denis A. MALYSHEV

    IPC分类号： C12N15/70 ,  C07K14/295 ,  C07K14/405

    摘要： A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. UBPs can therefore form within the cell's nucleic acids. Moreover, neither the presence of the unnatural triphosphates nor the replication of the UBP represents a significant growth burden. The UBP is not efficiently excised by nucleic acid repair pathways, and therefore can be retained as long as the unnatural triphosphates are available in the growth medium. Thus, the resulting cell is the first organism to stably propagate an expanded genetic alphabet.

    摘要翻译： 重组表达的三磷酸核苷酸转运蛋白有效地将非天然核苷酸的三磷酸进入细胞，并且内源细胞机制将这些核苷酸掺入到细胞核酸中。 因此，UBPs可以在细胞的核酸内形成。 此外，不自发三磷酸的存在和UBP的复制都不会代表显着的生长负担。 UBP没有被核酸修复途径有效地切除，因此只要在生长培养基中存在非天然三磷酸，就可以保留UBP。 因此，所得细胞是稳定繁殖扩展的遗传字母表的第一生物体。

    Vaccines for Chlamydia
    65.
    发明授权
    Vaccines for Chlamydia 有权
    衣原体疫苗

    公开(公告)号：US09308248B2

    公开(公告)日：2016-04-12

    申请号：US14126076

    申请日：2012-06-15

    申请人： Daisy Vanrompay

    发明人： Daisy Vanrompay

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/002 ,  A61K39/118 ,  C07K14/295

    CPC分类号： A61K39/118 ,  C07K14/295

    摘要： The present invention relates to means and methods to protect against disease caused by bacteria belonging to the genus Chlamydia. In particular, the present invention relates to isolated B- and T-cell epitopes derived from the major outer membrane protein of Chlamydia psittaci which can be used against an infection with a species of the genus Chlamydia. More in particular, the invention provides a vaccine which can be used against chlamydiosis caused by Chlamydia psittaci in birds and man. In addition, the invention relates to a diagnostic method to diagnose the latter infections.

    摘要翻译： 本发明涉及防止属于衣原体属细菌的疾病的手段和方法。 特别地，本发明涉及衍生自鹦鹉形衣原体的主要外膜蛋白的分离的B细胞和T细胞表位，其可用于抵抗衣原体属的感染。 更具体地，本发明提供了一种疫苗，其可以用于针对鹦鹉热衣原体在鸟类和人类中引起的衣原体感染。 此外，本发明涉及诊断后者感染的诊断方法。

    CHIMERIC MOMP ANTIGEN
    69.
    发明申请
    CHIMERIC MOMP ANTIGEN 有权
    CHIMERIC MOMP抗原

    公开(公告)号：US20130156805A1

    公开(公告)日：2013-06-20

    申请号：US13700662

    申请日：2011-05-27

    申请人： Sören Andersson ,  Åke Strid

    发明人： Sören Andersson ,  Åke Strid

    IPC分类号： C07K14/295

    CPC分类号： C07K14/295 ,  A61K39/118 ,  C07K2319/40

    摘要： The present invention regards polypeptides capable of eliciting an immunological response that is protective against Chlamydia trachomatis. The polypeptide comprises a first amino acid sequence which has at least 90% homology with the amino acid sequence according to SEQ ID NO: 1 and a second amino acid sequence which has at least 90% homology with the amino acid sequence according to SEQ ID NO: 2. Furthermore, production of these polypeptides and pharmaceutical compositions comprising them are also provided.

    摘要翻译： 本发明涉及能够诱导针对沙眼衣原体的免疫应答的多肽。 该多肽包含与根据SEQ ID NO：1的氨基酸序列具有至少90％同源性的第一氨基酸序列和与根据SEQ ID NO：1的氨基酸序列具有至少90％同源性的第二个氨基酸序列 此外，还提供了这些多肽和包含它们的药物组合物的生产。

    NOVEL DEATH DOMAIN PROTEINS
    70.
    发明申请
    NOVEL DEATH DOMAIN PROTEINS 审中-公开
    新的死亡蛋白质蛋白

    公开(公告)号：US20110201780A1

    公开(公告)日：2011-08-18

    申请号：US13050848

    申请日：2011-03-17

    申请人： John C. Reed ,  Adam Godzik ,  Krzysztof Pawlowski ,  Loredana Fiorentino ,  Sug Hyung Lee ,  Wilfried Roth ,  Frank Stenner-Liewen

    发明人： John C. Reed ,  Adam Godzik ,  Krzysztof Pawlowski ,  Loredana Fiorentino ,  Sug Hyung Lee ,  Wilfried Roth ,  Frank Stenner-Liewen

    IPC分类号： C07K14/295

    CPC分类号： C07K14/295 ,  C07K14/4747 ,  C07K2319/00

    摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

    摘要翻译： 根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。 本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。 这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物 疾病